公开(公告)号：EP0244352B1

公开(公告)日：1993-03-31

申请号：EP87810234.2

申请日：1987-04-10

Applicant: NIPPON ZOKI PHARMACEUTICAL CO. LTD.

Inventor： Go, Kouichiro / Inst. of Bio-Active Science, ,  Kurimoto, Yoshiyuki / Inst. of Bio-Active Science, ,  Kitamura, Norihiko / Inst. of Bio-Active Science,

IPC: C07D471/04 ,  A61K31/505

CPC classification number: C07D471/04

公开(公告)号：EP0162813B1

公开(公告)日：1992-03-11

申请号：EP85810246.0

申请日：1985-05-24

Applicant: NIPPON ZOKI PHARMACEUTICAL CO. LTD.

Inventor： Konishi, Jin-emon

IPC: C07K5/06 ,  A61K37/02

CPC classification number: C07K5/06026 ,  A61K38/00 ,  C07K5/06069 ,  C07K5/06147

公开(公告)号：EP0467856A2

公开(公告)日：1992-01-22

申请号：EP91810580.0

申请日：1991-07-18

Applicant: NIPPON ZOKI PHARMACEUTICAL CO. LTD.

Inventor： Higashiura, Kunihiko, Inst. of Bio-Active Science ,  Ienaga, Kazuharu, Inst. of Bio-Active Science ,  Hattori, Masao

IPC: A61K31/185 ,  A61K31/19 ,  A61K31/40 ,  A61K31/195 ,  C07C309/14 ,  C07C309/18 ,  C07C309/24 ,  C07C233/60 ,  C07D207/08 ,  C07D207/12

CPC classification number: A61K31/185 ,  A61K31/19 ,  A61K31/195 ,  A61K31/40 ,  C07C309/14

Abstract: The present invention relates to a pharmaceutical composition for use in preventing or treating heart diseases in a mammal, which comprises at least one aminoalkanesulfonic acid derivative of the formula (I) :
wherein X is hydrogen or an amino acid residue ; Y is hydrogen, a phenyl group or an alkyl group, which may have a hydroxy, amino, carboxy , phenyl or hydroxyphenyl group ; or X and Y are joined to form a trimethylene or hydroxytrimethylene group ; and at least one of X and Y is other than hydrogen ; or pharmaceutically acceptable salt thereof.

Abstract translation: 本发明涉及一种药物组合物，用于预防或在哺乳动物中，该方法包括将式（I）中的至少一个氨烷基羧酸衍生物治疗心脏疾病： worin X是氢或在氨基酸残基; Y是氢，苯基或烷基，可具有一个羟基，氨基，羧基，苯基或羟基苯基; 或X和Y结合以形成1,3-亚丙基或羟基三亚甲基; 和X中的至少一个和Y不是氢; 或药学上可接受的盐。

公开(公告)号：EP0381628A3

公开(公告)日：1991-05-02

申请号：EP90810073.8

申请日：1990-01-31

Applicant: NIPPON ZOKI PHARMACEUTICAL CO. LTD.

Inventor： Nakamura, Ko, c/o Institute of Bio-Active Science ,  Ienaga, Kazuhara, c/o Inst. of Bio-Active Science

IPC: C07D233/88 ,  C07D233/72 ,  G01N33/50

CPC classification number: C07D233/88 ,  Y02P20/55

Abstract: The glycocyamidine derivatives of the present invention are represented by the following formula (I):
wherein R₁, R₂ and R₃, which may be the same or different, is hydrogen or a lower alkyl group, preferably a straight or branched alkyl group having 1 to 3 carbon atoms, such as methyl, ethyl, propyl or isopropyl, and R represents hydrogen or an acetyl group,
which are useful as test reagents for diagnosis of renal failure.

公开(公告)号：EP0269574A3

公开(公告)日：1989-03-22

申请号：EP87810687.1

申请日：1987-11-23

Applicant: NIPPON ZOKI PHARMACEUTICAL CO. LTD.

Inventor： Yamada, Toshio c/o Institute of Bio-Active Science ,  Kageyama, Ken-ichi Institute of Bio-Active Science

IPC: C07H19/173 ,  A61K31/70

CPC classification number: C07H19/16 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0075 ,  A61K9/02 ,  A61K9/06 ,  A61K9/2018 ,  A61K9/4858 ,  A61K9/7023

Abstract: The present invention relates to novel adenosine derivatives having the formula (I):
wherein each of R₁, R₂ and R₃, which may be the same or different, is hydrogen or a lower alkyl group; X is hydrogen, a lower alkyl group, an amino group or halogen; and Y is hydrogen or a lower alkyl group;
and pharmaceutically acceptable salt thereof. These compounds are useful as antihypertensive agents, for example, for the treatments of hypertension and various diseases caused by hypertension, such as cerebrovascular diseases, cardiopathy or renal insufficiency.

公开(公告)号：EP0260707A2

公开(公告)日：1988-03-23

申请号：EP87113681.8

申请日：1987-09-18

Applicant: NIPPON ZOKI PHARMACEUTICAL CO. LTD.

Inventor： Matsumoto, Kenji, c/o Inst. of Bio-Active Science

IPC: C12Q1/56

CPC classification number: C12Q1/56 ,  C12Q2337/12 ,  G01N2333/7452 ,  G01N2333/8128 ,  G01N2333/96461 ,  G01N2333/974 ,  G01N2400/40

Abstract: An enzymic method for assaying protein C by the use of a synthetic peptide substrate, wherein the action of inter­fering substances against said peptide substrate are spe­cifically inhibited, and a measuring kit for the same.

Abstract translation: 用于通过使用合成肽底物测定蛋白质C的酶法，其中特异性抑制干扰物质对所述肽底物的作用及其测定试剂盒。

公开(公告)号：EP0259857A2

公开(公告)日：1988-03-16

申请号：EP87113185.0

申请日：1987-09-09

Applicant: NIPPON ZOKI PHARMACEUTICAL CO. LTD.

Inventor： Toyomaki, Yoshio, c/o Inst. of Bio-Active Science ,  Nishikawa, Katsumi, c/oInst. of Bio-Active Science ,  Kawakubo, Hitoshi, c/o Inst. of Bio-Active Science

IPC: C12Q1/37

CPC classification number: C12Q1/37 ,  C12Q1/56 ,  C12Q2337/22 ,  G01N2333/96455 ,  G01N2333/96458 ,  G01N2400/40

Abstract: A method of assaying a physiologically active substance, which comprises activating blood coagulation factor XII in the plasma in the presence of said physiologically active substance being tested to convert prekallikrein in the plasma into kallikrein, and measuring the activity of kal­likrein thus formed.

Abstract translation: 一种测定生理活性物质的方法，其包括在存在所述待测生理活性物质的情况下激活血浆中的血液凝固因子XII，以将血浆中的前激肽释放酶转化成激肽释放酶，并测量由此形成的激肽释放酶的活性。

公开(公告)号：EP0212332A2

公开(公告)日：1987-03-04

申请号：EP86110256.4

申请日：1982-12-09

Applicant: NIPPON ZOKI PHARMACEUTICAL CO. LTD.

Inventor： Konishi, Ryusaku

IPC: A61F13/02 ,  A61L15/16

CPC classification number: A61F13/0203 ,  A61L15/44 ,  A61L15/58 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/418 ,  A61L2300/62

Abstract: An adhesive bandage, comprising an adhesive tape (1), an absorbent pad (2) carried by the tape and a release sheet (4), releasably attached to the tape on the side of the adhesive, wherein said absorbent pad (2) is smaller in its length than the tape (1) and said release sheet (4) is overlaying the whole pad, said bandage further comprising a blister portion (6) having an open side facing the pad, formed on the release sheet, a medicine (3) contained in the blister, and a medicine covering film (5) interposed between the medicine and the pad for sealing the medicine in the blister, said film being rupturable under pressure, characterized in that the medicine (3) is encapsulated into a capsule (8) placed in the blister (6).

Abstract translation: 一种胶粘绷带，其包括粘合带（1），由带承载的吸收垫（2）和释放片（4），其可释放地附接到粘合剂侧面上的带，其中所述吸收垫（2）是 其长度小于带（1），并且所述剥离片（4）覆盖整个垫，所述绷带还包括形成在剥离片上的具有朝向垫的开口侧的泡罩部分（6），药物 3），以及介于所述药物和所述垫之间的药物覆盖膜（5），用于将所述药物密封在所述泡罩中，所述膜在压力下是可破裂的，其特征在于，所述药物（3）被包封在胶囊 （8）放置在泡罩（6）中。

公开(公告)号：EP0191735A3

公开(公告)日：1987-02-04

申请号：EP86810068

申请日：1986-02-10

Applicant: NIPPON ZOKI PHARMACEUTICAL CO. LTD.

Inventor： Ienaga, Kazuharu Nippon Zoki Pharmaceutical Co.Ltd ,  Nakamura, Ko Nippon Zoki Pharmaceutical Co.Ltd ,  Ishii, Akira Nippon Zoki Pharmaceutical Co.Ltd

IPC: C07C127/22 ,  C07D295/20 ,  A61K31/19 ,  A61K31/215

CPC classification number: C07D295/215 ,  C07C275/50 ,  C07C2601/08 ,  C07C2601/14

Abstract: 57 Oxaluric acid derivatives of the formula (I):
wherein each of R, and R 2 , which may be the same or different, represents a hydrogen atom, an alkyl or cycloalkyl group, or R, and R 2 taken together with the adjacent nitrogen atom form a heterocyclic ring and R 3 represents a hydrogen atom or an alkyl group as well as pharmaceutically acceptable salts and metal complexes thereof are disclosed. Pharmaceutical compositions containing the compounds as active ingredients are disclosed. The compounds possess hypoglycemic activity and are useful in the treatment of diabetes.

Abstract translation: 式（I）的草酸衍生物：... 其中R1和R2各自可以相同或不同，表示氢原子，烷基或环烷基，或R1和R2与相邻的 氮原子形成杂环，R 3表示氢原子或烷基，以及其药学上可接受的盐和金属络合物。 公开了含有这些化合物作为活性成分的药物组合物。 该化合物具有降血糖活性，可用于治疗糖尿病。

公开(公告)号：EP0163599A2

公开(公告)日：1985-12-04

申请号：EP85810182.7

申请日：1985-04-24

Applicant: NIPPON ZOKI PHARMACEUTICAL CO. LTD.

Inventor： Kitamura, Norihiko Inst. of Bio-Active Science ,  Ohnishi, Akimoto Nippon Zoki Pharm. Co. Ltd. 442-1

IPC: C07D487/04 ,  A61K31/505

CPC classification number: C07D239/545 ,  C07D239/557 ,  C07D487/04

Abstract: Pyrimidopyrimidine derivatives having the general formula (I):
wherein R 1 represents an alkyl group; R 2 represents an alkyl or phenyl group; R 3 represents a hydrogen atom or an alkyl or lower alkylamino group; and R 4 represents a hydrogen atom or an alkyl, halogenated lower alkyl, phenyl, amino or lower alkylamino group; and pharmaceutically acceptable salts thereof have anti-allergic properties. Various processes for preparing these pyrimidopyrimidine derivatives are disclosed.