利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

172 条记录 (耗时 0.024 秒)

    PREMOUNTED FLUID CONVEYANCE ASSEMBLY FOR CELL EXPANSION SYSTEM AND METHOD OF USE ASSOCIATED THEREWITH
    45.
    发明授权
    PREMOUNTED FLUID CONVEYANCE ASSEMBLY FOR CELL EXPANSION SYSTEM AND METHOD OF USE ASSOCIATED THEREWITH 有权
    用于电池膨胀系统的预制流体输送组件及使用相关方法

    公开(公告)号：EP2350256B1

    公开(公告)日：2017-08-30

    申请号：EP09752942.4

    申请日：2009-10-27

    申请人： Terumo BCT, Inc.

    发明人： DODD, Jon, A. ,  DILORENZO, Thomas, G. ,  CORBIN, Frank, III ,  ANTWILER, Glen, Delbert

    IPC分类号： C12M1/12 ,  C12M3/06 ,  C12M3/00

    CPC分类号： C12M23/48 ,  C12M23/42 ,  C12M25/10 ,  C12M25/12 ,  C12M29/00

    摘要： A premounted fluid conveyance assembly for use with a cell expansion machine comprises a tubing-organizer and a fluid conveyance system. The fluid conveyance system is at least partially attached to the tubing-organizer, and the fluid conveyance system comprises an oxygenator or gas transfer module, a length of tubing and a bioreactor all fluidly interconnected. The premounted fluid conveyance assembly is adapted to be detachably-attached to the cell expansion machine. Accordingly, after a premounted fluid conveyance assembly is used, it is removed from the cell expansion machine by disengaging it from the cell expansion machine. Thereafter, another premounted fluid conveyance assembly can be attached in place of the previously used premounted fluid conveyance assembly.

    摘要翻译： 与细胞膨胀机一起使用的预安装流体输送组件包括管道组织器和流体输送系统。 流体输送系统至少部分地附接到管道组织器，并且流体输送系统包括充氧器或气体输送模块，一段管道和生物反应器全部流体互连。 预安装的流体输送组件适于可拆卸地连接到电解槽膨胀机。 因此，在使用预安装的流体输送组件之后，通过将其从电池膨胀机脱离而将其从电池膨胀机移除。 此后，可以安装另一个预安装的流体输送组件来代替之前使用的预先安装的流体输送组件。

    PASSIVE REPLACEMENT OF MEDIA
    47.
    发明公开
    PASSIVE REPLACEMENT OF MEDIA 审中-公开
    佩斯内斯·维斯顿

    公开(公告)号：EP3122866A1

    公开(公告)日：2017-02-01

    申请号：EP15718657.8

    申请日：2015-03-25

    申请人： Terumo BCT, Inc.

    发明人： NANKERVIS, Brian J.

    IPC分类号： C12M1/00 ,  C12M1/12 ,  C12M1/36

    摘要： Embodiments described herein generally relate to passively replacing media in a closed cell expansion system to reduce or prevent the dilution of chemical signaling used to inhibit signaling pathways that keep a cell population in the lag phase of cell growth. To prevent such dilution, active inlet fluid flow to the system may be halted. To replace fluid lost by the system, a bag containing media may be attached to the waste line in replacement of the waste or outlet bag connected thereto. By turning off one or more pumps, media from the replacement bag is added to the system at the rate of evaporation. Chemical signaling dilution may be prevented while conserving system resources. Enhancement of chemical signaling to reduce the lag phase of cell growth may further be accomplished by adding molecules, such as chemical-signaling proteins, from a direct source to the system.

    摘要翻译： 本文描述的实施方案一般涉及被动更换闭孔扩增系统中的培养基，以减少或防止用于抑制细胞群落在细胞生长滞后阶段的信号通路的化学信号传递的稀释。 为了防止这种稀释，流入系统的主动入口流体可能会停止。 为了更换系统损失的液体，可以将含有介质的袋子连接到废物管线上，以代替与其连接的废物或出口袋。 通过关闭一个或多个泵，替换袋中的介质以蒸发速率被添加到系统中。 在保护系统资源的同时可以防止化学信号的稀释。 化学信号传导的增强以减少细胞生长的滞后期可以通过从直接来源向系统添加分子，例如化学信号蛋白来进一步实现。

    System for blood separation with gravity valve for controlling a side-tapped separation chamber
    49.
    发明授权
    System for blood separation with gravity valve for controlling a side-tapped separation chamber 有权
    一种用于与重力阀血液分离系统，用于控制具有侧螺纹孔分离室

    公开(公告)号：EP2815776B1

    公开(公告)日：2016-02-03

    申请号：EP14178043.7

    申请日：2012-06-12

    申请人： Terumo BCT, Inc.

    发明人： Holmes, Brian M. ,  Ladtkow, James R.

    IPC分类号： A61M1/36 ,  B04B5/04 ,  B01D21/26

    CPC分类号： B04B11/04 ,  A61M1/30 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/38 ,  B01D21/262 ,  B01D21/30 ,  B01D21/34 ,  B01D2221/10 ,  B04B5/0442 ,  B04B7/08 ,  B04B2005/045 ,  B04B2005/0471

    摘要： A disposable blood separation set and a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having an inlet, a primary outlet and a side tap outlet adjacent the inlet. A valve that is responsive to centrifugal force (a "gravity" valve) selects between the outlet and the side tap outlet. The gravity valve is mounted on the rotor. When the rotor spins at high speed, the gravity valve may open the primary outlet and close the side tap outlet. When the rotor spins at a lower speed, the gravity valve may open the side tap outlet and close the primary outlet.

    摘要翻译： 一种一次性血液分离，并设置包括血液处理腔室angepasst被安装在离心机的转子的离心血液处理系统; 在与处理室流体连通的截头圆锥形的细胞分离室，具有入口单元分离室，一个主出口和侧出口挖掘邻近入口。 阀那样响应于离心力（一个“重力”阀）的出口和出口侧抽头之间进行选择。 重力阀安装在转子上。 当转子转速为高速时，重力阀可以打开主出口，并关闭侧排渣口。 当转子旋转以较低的速度，重力阀可以打开侧抽头出口并关闭主出口。