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公开(公告)号：EP2454255B1
公开(公告)日：2013-11-06
申请号：EP10742897.1
申请日：2010-07-15
发明人： BOLLI, Martin , LESCOP, Cyrille , MATHYS, Boris , MORRISON, Keith , MUELLER, Claus , NAYLER, Oliver , STEINER, Beat
IPC分类号： C07D413/04 , A61K31/4439 , A61P37/00
CPC分类号： C07D413/04
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公开(公告)号：EP2069335B1
公开(公告)日：2012-12-26
申请号：EP07826286.2
申请日：2007-09-06
发明人： BOLLI, Martin , LEHMANN, David , MATHYS, Boris , MUELLER, Claus , NAYLER, Oliver , STEINER, Beat , VELKER, Jörg
IPC分类号： C07D413/04 , C07D417/04 , A61K31/4439 , A61P37/00 , A61P19/00 , A61P35/00 , A61P9/00
CPC分类号： C07D413/04 , C07D417/04
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公开(公告)号：EP2069318B1
公开(公告)日：2012-09-12
申请号：EP07805099.4
申请日：2007-07-10
发明人： BOLLI, Martin , LEHMANN, David , MATHYS, Boris , MUELLER, Claus , NAYLER, Oliver , STEINER, Beat , VELKER, Jörg
IPC分类号： C07D271/06 , C07D271/107 , A61K31/4245 , A61P37/00 , A61P35/00
CPC分类号： C07D271/06 , C07D271/107
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公开(公告)号：EP2454255A1
公开(公告)日：2012-05-23
申请号：EP10742897.1
申请日：2010-07-15
发明人： BOLLI, Martin , LESCOP, Cyrille , MATHYS, Boris , MORRISON, Keith , MUELLER, Claus , NAYLER, Oliver , STEINER, Beat
IPC分类号： C07D413/04 , A61K31/4439 , A61P37/00
CPC分类号： C07D413/04
摘要： The invention relates to pyridine derivatives of Formula (I), wherein A, R
1 , R
2 , R
3 , and R
4 are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.-
公开(公告)号：EP1863787B1
公开(公告)日：2011-05-25
申请号：EP06727679.0
申请日：2006-03-20
发明人： BOLLI, Martin , LEHMANN, David , MATHYS, Boris , MUELLER, Claus , NAYLER, Oliver , VELKER, Jörg , WELLER, Thomas
IPC分类号： C07D333/72 , C07D333/78 , C07D413/04 , C07D409/12 , C07D413/14 , A61K31/38 , A61K31/41 , A61P37/00
CPC分类号： C07D409/12 , C07D333/72 , C07D333/78 , C07D413/04 , C07D413/14
摘要： The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.
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公开(公告)号：EP2278960A1
公开(公告)日：2011-02-02
申请号：EP09721703.8
申请日：2009-03-12
IPC分类号： A61K31/00 , A61K31/426
摘要： The present invention relates to a dosing regimen for a selective S1P1 receptor agonist, whereby the selective S1P1 receptor agonist is administered to a subject in such a way that during the initial treatment phase the selective S1P1 receptor agonist is administered at a dose which induces desensitization of the heart wherein said dose is below the target dose, and at a dosing frequency that sustains desensitization of the heart, until no further acute heart rate reduction occurs, followed by dose up-titration to the target dose of the selective S1P1 receptor agonist.
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公开(公告)号：EP2262782A1
公开(公告)日：2010-12-22
申请号：EP09718505.2
申请日：2009-03-03
发明人： BOLLI, Martin , LESCOP, Cyrille , MATHYS, Boris , MUELLER, Claus , NAYLER, Oliver , STEINER, Beat
IPC分类号： C07D271/06 , A61K31/4245 , A61P37/00
CPC分类号： C07D271/06
摘要： The invention relates to novel aminomethyl benzene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents. (I) wherein A represents one of the groups (I), (I), (I) and (I).
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公开(公告)号：EP1979345B1
公开(公告)日：2009-11-04
申请号：EP07700666.6
申请日：2007-01-23
发明人： BOLLI, Martin , LEHMANN, David , MATHYS, Boris , MUELLER, Claus , NAYLER, Oliver , STEINER, Beat , VELKER, Jörg
IPC分类号： C07D409/06 , C07D413/14 , A61K31/4436 , A61K31/4439 , A61P37/00
CPC分类号： C07D409/06 , C07D413/14
摘要： The invention relates to novel pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.
摘要翻译： 本发明涉及新的吡啶衍生物，它们的制备及其作为药物活性化合物的用途。 所述化合物特别用作免疫抑制剂。
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公开(公告)号：EP2069336A1
公开(公告)日：2009-06-17
申请号：EP07826287.0
申请日：2007-09-06
发明人： BOLLI, Martin , LEHMANN, David , MATHYS, Boris , MUELLER, Claus , NAYLER, Oliver , STEINER, Beat , VELKER, Jörg
IPC分类号： C07D413/04 , C07D417/04 , A61K31/4439 , A61P37/00 , A61P19/00 , A61P35/00 , A61P9/00
CPC分类号： C07D413/04 , C07D417/04
摘要： The invention relates to pyridine derivatives of Formula (I) wherein A, R1, R2, R3, R4, R5, and R6 are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.
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50.发明公开NOVEL THIOPHENE DERIVATIVES AS SPHINGOSINE-1-PHOSPHATE-1 RECEPTOR AGONISTS 有权新的噻吩衍生物作为天冬氨酸-1-磷酸酯-1受体激动剂
公开(公告)号：EP1863475A2
公开(公告)日：2007-12-12
申请号：EP06727686.5
申请日：2006-03-20
发明人： BOLLI, Martin , LEHMANN, David , MATHYS, Boris , MUELLER, Claus , NAYLER, Oliver , VELKER, Jörg , WELLER, Thomas
IPC分类号： A61K31/381
CPC分类号： C07D213/82 , C07D295/155 , C07D333/78 , C07D409/10 , C07D409/12
摘要： The invention relates to novel thiophene derivatives of Formula (I), their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.
摘要翻译： 本发明涉及式（I）的新型噻吩衍生物，它们的制备及其作为药物活性化合物的用途。 所述化合物特别用作免疫抑制剂。
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