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41.发明公开
公开(公告)号：EP0896614A1
公开(公告)日：1999-02-17
申请号：EP96910504.0
申请日：1996-03-21
发明人： NI, Jian , YU, Guo-Liang , GENTZ, Reiner, L.
CPC分类号： C07K14/4702 , A61K38/00 , A61K48/00
摘要： The invention relates to hESF I, II and III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
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公开(公告)号：EP0856006A1
公开(公告)日：1998-08-05
申请号：EP95935236.0
申请日：1995-09-29
发明人： NI, Jian , YU, Guo-Liang , GENTZ, Reiner
CPC分类号： C07K14/475 , A61K48/00 , C12N2799/026
摘要： The invention relates to cytostatin II growth modulatory peptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications which are related, in part, to research, diagnostic and clinical arts.
摘要翻译： 本发明涉及细胞抑制素II生长调节肽，编码所述多肽的多核苷酸，产生所述多肽的方法，特别是通过表达所述多核苷酸，以及所述多肽的激动剂和拮抗剂。 本发明进一步涉及将这些多核苷酸，多肽，激动剂和拮抗剂用于部分涉及研究，诊断和临床领域的应用的方法。
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公开(公告)号：EP0847398A1
公开(公告)日：1998-06-17
申请号：EP95923764.0
申请日：1995-06-06
发明人： YU, Guo-Liang , ROSEN, Craig, A.
摘要： Human colon specific gene polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides or polypeptides as a diagnostic marker for colon cancer and as an agent to determine if colon cancer has metastasized. Also disclosed are antibodies specific to the colon specific gene polypeptides which may be used to target cancer cells and be used as part of a colon cancer vaccine. Methods of screening for agonists and antagonists for the polypeptides and therapeutic uses of the antagonists are disclosed.
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公开(公告)号：EP0842187A1
公开(公告)日：1998-05-20
申请号：EP95922973.0
申请日：1995-06-05
发明人： NI, Jian , YU, Guo-Liang , GENTZ, Reiner , ROSEN, Craig, A.
CPC分类号： C07K14/8139 , A61K38/00 , A61K48/00 , C12N2799/026
摘要： Disclosed is a human CysE polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for treating osteoporosis, tumor metastases, microbial infections, viral infection, septic shock, inflammation, retinal irritation, caries, cachicia and muscle wasting. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.
摘要翻译： 公开了编码这种多肽的人CysE多肽和DNA（RNA）。 还提供了通过重组技术生产这种多肽的程序。 还公开了利用这种多肽治疗骨质疏松症，肿瘤转移，微生物感染，病毒感染，脓毒性休克，炎症，视网膜刺激，龋齿，c螨和肌肉萎缩的方法。 还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度改变的诊断方法。
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公开(公告)号：EP0792278A1
公开(公告)日：1997-09-03
申请号：EP95903521.0
申请日：1994-11-07
发明人： YU, Guo-Liang , NI, Jian , ROSEN, Craig, A.
IPC分类号： G01N33 , A61K31 , A61K38 , A61K45 , A61K48 , A61P9 , A61P29 , A61P31 , A61P33 , A61P35 , A61P43 , C07K14 , C07K16 , C12N1 , C12N5 , C12N15 , C12P21 , C12Q1 , C12R1
CPC分类号： C07K14/525 , A61K38/00 , Y02A50/412
摘要： A human TNF-gamma polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma nucleic acid sequence or an overexpression of the TNF-gamma polypeptide. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
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公开(公告)号：EP1015477B1
公开(公告)日：2010-11-10
申请号：EP98926105.2
申请日：1998-05-28
发明人： RUBEN, Steven, M. , ROSEN, Craig, A. , CARTER, Kenneth, C. , DILLON, Patrick, J. , ENDRESS, Gregory, A. , YU, Guo-Liang , NI, Jian , FENG, Ping
IPC分类号： C07K14/525
CPC分类号： C07K14/47 , A61K38/00 , C07K14/525 , G01N2500/04
摘要： The present invention relates to 32 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及32种新型人分泌蛋白和含有编码这种蛋白质的基因的编码区的分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病的诊断和治疗方法。
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公开(公告)号：EP1294949A2
公开(公告)日：2003-03-26
申请号：EP01961605.1
申请日：2001-06-14
CPC分类号： A61K49/0004 , A61K47/6849 , A61K2039/505 , C07K14/52 , C07K14/70575 , C07K16/2875 , C07K2317/21 , C07K2317/622 , G01N33/564
摘要： The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
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公开(公告)号：EP1196191A1
公开(公告)日：2002-04-17
申请号：EP00930329.8
申请日：2000-05-04
发明人： NI, Jian , GENTZ, Reiner, L. , YU, Guo-Liang , ROSEN, Craig, A.
IPC分类号： A61K39/00 , A61K39/395 , A61K45/00 , A01N37/18 , C07K14/52 , C07K14/525 , C07K16/28
CPC分类号： C07K14/70578 , A61K38/00 , A61K39/395 , C07K2319/00 , C07K2319/30 , A61K38/191 , A61K38/19 , A61K38/177 , A61K31/00 , A61K2300/00
摘要： The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR5 acitivity.
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公开(公告)号：EP0775199B1
公开(公告)日：2002-04-03
申请号：EP94923172.4
申请日：1994-05-31
CPC分类号： C12N9/0089 , A61K38/00
摘要： Polynucleotides which encode the polypeptide SOD-4, as well as such polypeptides, and antibodies against the polypeptide and the use of the polypeptide as a pharmaceutical for treating cerebral ischaemia, ulcers, inflammation, arrhythmia, oedema and paraquat intoxication as well as rheumatoid arthritis, osteoarthritis and radiation injury.
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公开(公告)号：EP1051426A1
公开(公告)日：2000-11-15
申请号：EP99904290.6
申请日：1999-01-27
发明人： RUBEN, Steven, M. , FERRIE, Ann, M. , ROSEN, Craig, A. , FLORENCE, Kimberly, A. , CARTER, Kenneth, C. , SOPPET, Daniel, R. , YU, Guo-Liang , FLORENCE, Charles , YOUNG, Paul , NI, Jian , FENG, Ping , ENDRESS, Gregory, A. , JANAT, Fouad
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
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