公开(公告)号：EP1078046A1

公开(公告)日：2001-02-28

申请号：EP99921691.4

申请日：1999-05-06

申请人： Human Genome Sciences, Inc.

发明人： RUBEN, Steven, M. ,  FLORENCE, Kimberly ,  NI, Jian ,  ROSEN, Craig, A. ,  CARTER, Kenneth, C. ,  MOORE, Paul, A. ,  OLSEN, Henrik, S. ,  SHI, Yang-gu ,  YOUNG, Paul, E. ,  WEI, Fing-Fei ,  BREWER, Laurie A. ,  SOPPET, Daniel, R. ,  LAFLEUR, David, W. ,  ENDRESS, Gregory, A. ,  EBNER, Reinhard

IPC分类号： C12N15/00 ,  C12N15/12 ,  C07K14/00 ,  C07K14/435

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

公开(公告)号：EP1032838A1

公开(公告)日：2000-09-06

申请号：EP98956533.8

申请日：1998-11-04

申请人： Human Genome Sciences, Inc.

发明人： FENG, Ping ,  CARTER, Kenneth, C. ,  ENDRESS, Gregory, A. ,  ROSEN, Craig, A. ,  RUBEN, Steven, M. ,  JANAT, Fouad ,  NI, Jian ,  WEI, Ying-Fei ,  MOORE, Paul, A. ,  SOPPET, Daniel, R. ,  KYAW, Hla ,  LaFLEUR, David, W. ,  OLSEN, Henrik, S. ,  SHI, Yanggu ,  EBNER, Reinhard

IPC分类号： G01N33/68 ,  G01N33/53 ,  C07K16/00 ,  C12N15/11 ,  C12N15/12 ,  C12N15/00 ,  C12N15/63 ,  A61K38/17 ,  A61K38/16 ,  C12P21/02

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K2319/30

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

公开(公告)号：EP1015477A1

公开(公告)日：2000-07-05

申请号：EP98926105.2

申请日：1998-05-28

申请人： HUMAN GENOME SCIENCES, INC.

发明人： RUBEN, Steven, M. ,  ROSEN, Craig, A. ,  CARTER, Kenneth, C. ,  DILLON, Patrick, J. ,  ENDRESS, Gregory, A. ,  YU, Guo-Liang ,  NI, Jian ,  FENG, Ping

IPC分类号： C07K1/00 ,  C07H21/04

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/525 ,  G01N2500/04

摘要： The present invention relates to 32 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

公开(公告)号：EP1109821A1

公开(公告)日：2001-06-27

申请号：EP99942469.0

申请日：1999-08-24

申请人： Human Genome Sciences, Inc.

发明人： MOORE, Paul, A. ,  RUBEN, Steven, M. ,  OLSEN, Henrik, S. ,  SHI, Yang-gu ,  ROSEN, Craig, A. ,  FLORENCE, Kimberly, A. ,  SOPPET, Daniel, R. ,  LAFLEUR, David, W. ,  ENDRESS, Gregory, A. ,  EBNER, Reinhard ,  KOMATSOULIS, George ,  DUAN, Roxanne, D.

IPC分类号： C07H21/04 ,  C07K1/00 ,  C12N1/20 ,  C12P21/06

CPC分类号： C07K14/47

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

公开(公告)号：EP1100808A1

公开(公告)日：2001-05-23

申请号：EP99940847.9

申请日：1999-08-02

申请人： HUMAN GENOME SCIENCES, INC. ,  Beth Israel Deaconess Medical Center

发明人： LIBERMANN, Towia, Aron ,  OETTGEN, Joerg, Peter ,  KUNSCH, Charles, A. ,  ENDRESS, Gregory, A. ,  ROSEN, Craig, A.

IPC分类号： C07H21/00 ,  C12N1/15 ,  C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63

CPC分类号： C07K14/4702 ,  A61K38/00

摘要： The present invention relates to a novel human protein called Prostate Derived Ets Factor, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.

公开(公告)号：EP1044210A1

公开(公告)日：2000-10-18

申请号：EP98964122.0

申请日：1998-12-17

申请人： Human Genome Sciences, Inc.

发明人： RUBEN, Steven, M. ,  ROSEN, Craig, A. ,  EBNER, Reinhard ,  SOPPET, Daniel, R. ,  ENDRESS, Gregory, A. ,  FLORENCE, Kimberly, A. ,  YU, Guo-Liang

IPC分类号： C07H21/00 ,  C12N1/15 ,  C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63

CPC分类号： C07K14/705 ,  A61K38/00

摘要： The present invention relates to novel Dendriac and novel Brainiac-3 polypeptides which are members of the Brainiac family. In particular, isolated nucleic acid molecules are provided encoding the human Dendriac and Brainiac-3 polypeptides. Dendriac and Brainiac-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Dendriac and Brainiac-3 activities. Also provided are diagnostic methods for detecting immune and nervous system-related disorders and therapeutic methods for treating immune and nervous system-related disorders.

公开(公告)号：EP1015477B1

公开(公告)日：2010-11-10

申请号：EP98926105.2

申请日：1998-05-28

申请人： HUMAN GENOME SCIENCES, INC.

发明人： RUBEN, Steven, M. ,  ROSEN, Craig, A. ,  CARTER, Kenneth, C. ,  DILLON, Patrick, J. ,  ENDRESS, Gregory, A. ,  YU, Guo-Liang ,  NI, Jian ,  FENG, Ping

IPC分类号： C07K14/525

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/525 ,  G01N2500/04

摘要： The present invention relates to 32 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

摘要翻译： 本发明涉及32种新型人分泌蛋白和含有编码这种蛋白质的基因的编码区的分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病的诊断和治疗方法。

公开(公告)号：EP1097199A1

公开(公告)日：2001-05-09

申请号：EP99937247.7

申请日：1999-07-14

申请人： Human Genome Sciences, Inc.

发明人： RUBEN, Steven, M. ,  KOMATSOULIS, George ,  DUAN, Roxanne, D. ,  ROSEN, Craig, A. ,  MOORE, Paul, A. ,  SHI, Yang-gu ,  LAFLEUR, David, W. ,  EBNER, Reinhard ,  OLSEN, Henrik, S. ,  BREWER, Laurie, A. ,  FLORENCE, Kimberly, A. ,  YOUNG, Paul, E. ,  MUCENSKI, Michael,Human Genome Sciences, Inc. ,  ENDRESS, Gregory, A. ,  SOPPET, Daniel, R.

IPC分类号： C12N15/11 ,  C12N15/00 ,  C12N15/63 ,  C07H21/02 ,  C07H21/04

CPC分类号： C07K14/47 ,  G01N2500/20

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

公开(公告)号：EP1088071A1

公开(公告)日：2001-04-04

申请号：EP99930252.4

申请日：1999-06-15

申请人： Human Genome Sciences, Inc.

发明人： RUBEN, Steven, M. ,  NI, Jian ,  ROSEN, Craig, A. ,  WEI, Ying-Fei ,  YOUNG, Paul, E. ,  FLORENCE, Kimberly, A. ,  SOPPET, Daniel, R. ,  BREWER, Laurie A. ,  ENDRESS, Gregory, A. ,  CARTER, Kenneth, C. ,  MUCENSKI, Michael ,  EBNER, Reinhard ,  LAFLEUR, David, W. ,  OLSEN, Henrik, S. ,  SHI, Yanggu ,  MOORE, Paul, A. ,  KOMATSOULIS, George

IPC分类号： C12N15/12 ,  C12N15/63 ,  C12N1/21 ,  C12N5/00 ,  C07K7/00 ,  C07K14/435

CPC分类号： G01N33/6893 ,  A61K38/00 ,  C07K14/47 ,  G01N2500/20

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

公开(公告)号：EP1051426A1

公开(公告)日：2000-11-15

申请号：EP99904290.6

申请日：1999-01-27

申请人： Human Genome Sciences, Inc.

发明人： RUBEN, Steven, M. ,  FERRIE, Ann, M. ,  ROSEN, Craig, A. ,  FLORENCE, Kimberly, A. ,  CARTER, Kenneth, C. ,  SOPPET, Daniel, R. ,  YU, Guo-Liang ,  FLORENCE, Charles ,  YOUNG, Paul ,  NI, Jian ,  FENG, Ping ,  ENDRESS, Gregory, A. ,  JANAT, Fouad

IPC分类号： C07H21/04 ,  C12N5/00

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.