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公开(公告)号：EP0990031A2
公开(公告)日：2000-04-05
申请号：EP98904528.1
申请日：1998-01-13
发明人： WEI, Ying-Fei , NI, Jian , EBNER, Reinhard , YU, Guo-Liang , RUBEN, Steven, M. , GENTZ, Reiner, L. , FENG, Ping
IPC分类号： C12N15/12 , C12N15/70 , C12N15/85 , C12N15/86 , C12N1/21 , C12N5/10 , C07K14/705 , C07K16/28 , A61K38/17
CPC分类号： C07K14/70578 , A61K48/00
摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as 'TNFR-5' or 'TR5', and now referred to hereinafter as 'TRAIL receptor without intracellular domain' or 'TRID'. TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.
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公开(公告)号：EP1040117A1
公开(公告)日：2000-10-04
申请号：EP98966461.0
申请日：1998-12-17
发明人： MOORE, Paul, A. , RUBEN, Steven, M. , CARTER, Kenneth, C. , SHI, Yang-gu , ROSEN, Craig, A. , SOPPET, Daniel, R. , KYAW, Hla , WEI, Ying-Fei , FLORENCE, Kimberly , DUAN, Roxanne, D. , FLORENCE, Charles , GREENE, John, M. , FENG, Ping , FERRIE, Ann, M. , YU, Guo-Liang , JANAT, Fouad , NI, Jian
CPC分类号： C07K14/4702 , A61K38/00 , A61K48/00 , C07K14/47 , C07K14/4718 , C07K14/705 , C07K2319/00 , C07K2319/02 , C12N15/11 , C12N2799/026
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
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公开(公告)号：EP1005544A1
公开(公告)日：2000-06-07
申请号：EP98940950.3
申请日：1998-08-18
发明人： RUBEN, Steven, M. , YOUNG, Paul, E. , BREWER, Laurie, A. , EBNER, Reinhard , OLSEN, Henrik, S. , FLORENCE, Kimberly, A. , ROSEN, Craig, A. , DUAN, Roxanne , MOORE, Paul, A. , SHI, Yanggu , LAFLEUR, David, W. , FLORENCE, Charles , SOPPET, Daniel, R. , ENDRESS, Gregory, A. , FENG, Ping , KOMATSOULIS, George, A.
IPC分类号： C12N15/11 , C12N15/63 , C12N15/00 , C12N15/12 , A61K38/17 , C07K16/00 , C12P21/02 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/47 , A61K38/00 , G01N33/6893 , G01N2500/20
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
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公开(公告)号：EP1003763A1
公开(公告)日：2000-05-31
申请号：EP98939145.3
申请日：1998-07-29
发明人： RUBEN, Steven, M. , FENG, Ping , LAFLEUR, David, W. , MOORE, Paul, A. , SHI, Yanggu , KYAW, Hla , LI, Yi , ZENG, Zhizhen , CARTER, Kenneth, C. , ENDRESS, Gregory, A. , WEI, Ying-Fei , FAN, Ping , ROSEN, Craig, A.
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
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公开(公告)号：EP1159286A1
公开(公告)日：2001-12-05
申请号：EP00916071.4
申请日：2000-03-03
发明人： GENTZ, Reiner, L. , NI, Jian , EBNER, Reinhard , YU, Guo-Liang , RUBEN, Steven, M. , FENG, Ping
CPC分类号： C07K14/7151 , A61K38/00
摘要： The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α and -6β proteins. TNFR-6α and -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α and -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
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公开(公告)号：EP1039801A1
公开(公告)日：2000-10-04
申请号：EP98926237.3
申请日：1998-06-04
发明人： YOUNG, Paul , GREENE, John , FERRIE, Ann, M. , RUBEN, Steven , ROSEN, Craig , HU, Jing-Shan , OLSEN, Henrik , EBNER, Reinhard , BREWER, Laurie, A. , MOORE, Paul, A. , SHI, Yanggu e , FLORENCE, Charles , FLORENCE, Kimberly , LAFLEUR, David , NI, Jian , FAN, Ping , WEI, Ying-Fei , FISCHER, Carrie , SOPPET, Daniel , LI, Yi , ZENG, Zizhen , KYAW, Hla , YU, Guo-Liang , FENG, Ping , DILLON, Patrick , ENDRESS, Gregory , CARTER, Kenneth
IPC分类号： A01N37/18
CPC分类号： C07K14/4702 , A61K38/00 , A61K48/00 , C07K14/4718 , G01N33/68
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公开(公告)号：EP1032838A1
公开(公告)日：2000-09-06
申请号：EP98956533.8
申请日：1998-11-04
发明人： FENG, Ping , CARTER, Kenneth, C. , ENDRESS, Gregory, A. , ROSEN, Craig, A. , RUBEN, Steven, M. , JANAT, Fouad , NI, Jian , WEI, Ying-Fei , MOORE, Paul, A. , SOPPET, Daniel, R. , KYAW, Hla , LaFLEUR, David, W. , OLSEN, Henrik, S. , SHI, Yanggu , EBNER, Reinhard
IPC分类号： G01N33/68 , G01N33/53 , C07K16/00 , C12N15/11 , C12N15/12 , C12N15/00 , C12N15/63 , A61K38/17 , A61K38/16 , C12P21/02
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/30
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
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公开(公告)号：EP1015477A1
公开(公告)日：2000-07-05
申请号：EP98926105.2
申请日：1998-05-28
发明人： RUBEN, Steven, M. , ROSEN, Craig, A. , CARTER, Kenneth, C. , DILLON, Patrick, J. , ENDRESS, Gregory, A. , YU, Guo-Liang , NI, Jian , FENG, Ping
CPC分类号： C07K14/47 , A61K38/00 , C07K14/525 , G01N2500/04
摘要： The present invention relates to 32 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
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公开(公告)号：EP1007663A2
公开(公告)日：2000-06-14
申请号：EP98903557.1
申请日：1998-01-21
发明人： NI, Jian , ROSEN, Craig, A. , GENTZ, Reiner, L. , FENG, Ping , KRISSANSEN, Geoffery, W. , SU, Jeffrey, Y.
CPC分类号： C07K14/70535 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C12N9/6421 , C12N9/6475 , C12N9/6489 , C12N9/6491 , C12N2799/026
摘要： The present invention relates to novel human proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells and recombinant methods for producing the proteins of the invention. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
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公开(公告)号：EP1015477B1
公开(公告)日：2010-11-10
申请号：EP98926105.2
申请日：1998-05-28
发明人： RUBEN, Steven, M. , ROSEN, Craig, A. , CARTER, Kenneth, C. , DILLON, Patrick, J. , ENDRESS, Gregory, A. , YU, Guo-Liang , NI, Jian , FENG, Ping
IPC分类号： C07K14/525
CPC分类号： C07K14/47 , A61K38/00 , C07K14/525 , G01N2500/04
摘要： The present invention relates to 32 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及32种新型人分泌蛋白和含有编码这种蛋白质的基因的编码区的分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病的诊断和治疗方法。
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