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公开(公告)号：EP1056487A1
公开(公告)日：2000-12-06
申请号：EP99908402.3
申请日：1999-02-23
CPC分类号： A61L31/148 , A61B2017/00871 , A61L27/18 , A61L27/50 , A61L27/58 , A61L29/148 , A61L2400/16
摘要： Biodegradable shape memory polymer compositions, articles of manufacture thereof, and methods of preparation and use thereof are described. In one embodiment the compositions include at least one hard segment and at least one soft segment. The Ttrans of the hard segment is preferably between -30 and 270 °C. At least one of the hard or soft segments can contain a cross-linkable group, and the segments can be linked by formation of an interpenetrating network or a semi-interpenetrating network, or by physical interactions of the segments. Objects can be formed into a given shape at a temperature above the Ttrans of the hard segment, and cooled to a temperature below the Ttrans of the soft segment. If the object is subsequently formed into a second shape, the object can return to its original shape by heating the object above the Ttrans of the soft segment and below the Ttrans of the hard segment.
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42.发明公开SEMI-INTERPENETRATING OR INTERPENETRATING POLYMER NETWORKS FOR DRUG DELIVERY AND TISSUE ENGINEERING 失效半满还是联锁聚合物网络用于药物输送和GEWEBSHERSTELLUNG
公开(公告)号：EP1011633A1
公开(公告)日：2000-06-28
申请号：EP98923737.5
申请日：1998-05-22
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , University Technology Corporation , THE GENERAL HOSPITAL CORPORATION
CPC分类号： A61K9/0024 , A61K9/0019 , A61K47/32 , A61L27/26 , A61L27/38 , A61L27/3804 , A61L27/3852 , A61L27/50 , A61L27/52 , Y10S525/903 , Y10S525/937
摘要： Compositions for tissue engineering and drug delivery have been developed based on solutions of two or more polymers which form semi-interpenetrating or interpenetrating polymer networks upon exposure to active species following injection at a site in a patient in need thereof. The polymers crosslink to themselves but not to each other; semi-interpenetrating networks are formed when only one of the polymers crosslink. The resulting viscous solutions retain the biologically active molecules or cells at the site of injection until release or tissue formation, respectfully, occurs. As a result of studies conducted with polymer-cell suspensions forming interpenetrating polymer networks, it has been determined that polymer solutions can be formulated wherein the active species is provided by exposure of the polymer solution to an exogenous source of active species, typically electromagnetic radiation, preferably light. Studies demonstrate that light will penetrate through skin, body fluids (such as synovial fluid) and membranes and polymerize the polymer solutions. The polymer solutions can be crosslinked ionically or covalently, to form a hydrogel, semi-interpenetrating polymer network or an interpenetrating polymer network.
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公开(公告)号：EP0354916B1
公开(公告)日：1992-09-30
申请号：EP88903515.0
申请日：1988-03-07
CPC分类号： B01D69/141 , A61M1/3675 , C12N11/08 , C12N11/10
摘要： A method for the elimination of systemic heparin or low molecular weight derivatives of heparin wherein a blood filter containing an immobilized enzyme, including enzymes such as heparinase, glucuronate-reductase, aldose-reductase, beta-glucuronidase, O-sulfatase, and N-sulfatase, or other heparin degrading or neutralizing compound is constructed for use at the effluent of an extracorporeal device. The device meets specific stringent guidelines for clinical use. The first requirement is biocompatibility of the entire system. Secondly, the system is designed to remove clinical levels of heparin at variable flow rates, up to 4 liters blood/min for an adult to as low as 50 ml blood/min for an infant with perfusion times varying from hours up to between two and ten days for neonatal respiratory failure. Specific embodiments employing heparinase bound by tresyl chloride or CNBr techniques to reconstituted cellulose hollow fiber devices of the type used for kidney dialysis are disclosed. These include single or multistage devices suitable for heparin removal alone or in combination with dialysis or oxygenation. Also disclosed are analogous multiple membrane sheet devices.
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公开(公告)号：EP3155024B1
公开(公告)日：2020-09-16
申请号：EP15806017.8
申请日：2015-06-11
发明人： BELLINGER, Andrew , ZHANG, Shiyi , TRAVERSO, Carlo, Giovanni , LANGER, Robert, S. , MO, Stacy , GRANT, Tyler , JAFARI, Mousa , GLETTIG, Dean Liang , DICICCIO, Angela , WOOD, Lowell L. Jr. , ECKHOFF, Philip A.
IPC分类号： A61K9/00
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公开(公告)号：EP3624888A1
公开(公告)日：2020-03-25
申请号：EP18801958.2
申请日：2018-05-17
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46.发明公开
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公开(公告)号：EP3352785A1
公开(公告)日：2018-08-01
申请号：EP16782125.5
申请日：2016-09-23
发明人： KHAN, Omar, F. , ANDERSON, Daniel, G. , LANGER, Robert, S. , CHAHAL, Jasdave, S. , PLOEGH, Hidde , CANNER, David A. , JACKS, Tyler E.
IPC分类号： A61K39/002 , A61L31/10 , A61K39/12 , A61K39/145 , A61K9/00 , A61K47/34 , A61K9/107 , A61K48/00 , C12N15/87 , A61P33/02 , A61P31/16 , A61P31/12 , A61P31/00
CPC分类号： A61K39/0012 , A61K9/0019 , A61K9/5146 , A61K31/713 , A61K39/002 , A61K39/12 , A61K39/145 , A61K2039/53 , A61K2039/645 , A61K2039/70 , B82Y5/00 , C12N15/88 , C12N2740/16234 , C12N2760/14134 , C12N2760/16034 , C12N2770/24134 , C12N2770/36143 , Y02A50/392
摘要： Compositions and methods for modified dendrimer nanoparticle (“MDNP”) delivery of therapeutic, prophylactic and/or diagnostic agent such as large repRNA molecules to the cells of a subject have been developed. MDNPs efficiently drive proliferation of antigen-specific T cells against intracellular antigen, and potentiate antigen-specific antibody responses. MDNPs can be multiplexed to deliver two or more different repRNAs to modify expression kinetics of encoded antigens and to simultaneous deliver repRNAs and mRNAs including the same UTR elements that promote expression of encoded antigens.
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公开(公告)号：EP2365962B1
公开(公告)日：2017-07-05
申请号：EP09825132.5
申请日：2009-11-06
发明人： MAHON, Kerry, Peter , LOVE, Kevin, Thomas , LEVINS, Christopher, G. , WHITEHEAD, Kathryn, Ann , LANGER, Robert, S. , ANDERSON, Daniel, Griffith
IPC分类号： A61K48/00 , C12N15/11 , C07D295/13
CPC分类号： C07D295/13 , A61K9/107 , A61K9/1271 , A61K9/5123 , A61K31/7088 , A61K38/02 , A61K47/16 , A61K47/54 , A61K47/545 , A61K48/0025 , B01J2531/0252 , B01J2531/845 , C07C215/14 , C07C217/08 , C12N15/111 , C12N15/1137 , C12N15/88 , C12N2310/14 , C12N2310/3515 , C12N2320/32
摘要： Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
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公开(公告)号：EP2791210A1
公开(公告)日：2014-10-22
申请号：EP12809954.6
申请日：2012-12-15
发明人： VEGAS, Arturo, Jose , WHITEHEAD, Kathryn, Ann , ANDERSON, Daniel, Griffith , LANGER, Robert, S. , DORKIN, Joseph, R.
CPC分类号： A61K47/34 , A61K9/1271 , A61K9/5146 , A61K31/713 , A61K33/00 , A61K38/16 , A61K39/00 , C08G12/06 , C08G12/34 , C08G73/00 , C08L79/00 , C12N15/113
摘要： α-Aminoamidine polymers and methods of preparing a-aminoamidine polymers by reacting by reacting one or more amines with one or more isocyanides and one or more aldehydes are described. Methods of preparing a-aminoamidine polymers from commercially available starting materials are also provided, wherein the starting materials are racemic or stereochemically pure. a-Aminoamidine polymers or salt forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems and for other purposes as well such as, for example, coatings, additives, excipients, plastics, and materials, etc. Given the amino moiety of these α-aminoamidine polymers, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive α-aminoamidine polymers and polynucleotides can be prepared. The inventive α-aminoamidine polymers may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
摘要翻译： 描述了α-氨基脒聚合物和通过使一种或多种胺与一种或多种异氰化物和一种或多种醛反应来制备α-氨基脒聚合物的方法。 还提供了由市售原料制备α-氨基脒聚合物的方法，其中原料是外消旋或立体化学纯的。 α-氨基脒聚合物或其盐形式优选是可生物降解的和生物相容的，并且可以用于多种药物递送系统中以及用于其他目的，例如涂料，添加剂，赋形剂，塑料和材料等。给定的 这些α-氨基脒聚合物的氨基部分，它们特别适合于递送多核苷酸。 可以制备含有本发明的α-氨基脒聚合物和多核苷酸的复合物，胶束，脂质体或颗粒。 本发明的α-氨基脒聚合物也可以用于制备用于药物递送的微粒。 考虑到它们缓冲周围环境pH的能力，它们在提供不稳定剂方面特别有用。
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50.发明公开NANOLITER-SCALE SYNTHESIS OF ARRAYED BIOMATERIALS AND SCREENING THEREOF 审中-公开数组在设置于纳米生物材料升的规模，它的筛选合成
公开(公告)号：EP1675943A2
公开(公告)日：2006-07-05
申请号：EP04788758.3
申请日：2004-09-15
CPC分类号： C12N5/0606 , C12N2503/02 , C12N2533/30 , G01N33/5073 , G01N2500/10
摘要： A population of embryonic epithelial cells produced in vitro from embryonic stem cells. In one embodiment, at least 45% of the cells express cytokeratin, for example, cytokeratin-7. A method of screening cell-polymer interactions. The method includes depositing monomers as a plurality of discrete elements on a substrate, causing the deposited monomers to polymerize, thereby creating an array of discrete polymer elements on the substrate, incubating the substrate in a cell-containing culture medium, and characterizing a predetermined cell behavior on each polymer element.
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