公开(公告)号：EP4143187A1

公开(公告)日：2023-03-08

申请号：EP21723390.7

申请日：2021-04-27

申请人： Novartis AG

发明人： FAIRHURST, Robin Alec ,  FRITSCH, Christine ,  GERSPACHER, Marc ,  HINRICHS, Jürgen Hans-Hermann ,  LANGLOIS, Jean-Baptiste Georges Armand ,  LEBLANC, Catherine ,  LI, Tengfei ,  LORTHIOIS, Edwige Liliane Jeanne ,  MURA, Christophe ,  NIETO-OBERHUBER, Cristina Montserrat ,  TODOROV, Milen ,  VAUPEL, Andrea ,  WARIN, Nicolas ,  WILCKEN, Rainer

IPC分类号： C07D471/04 ,  C07D519/00 ,  A61P35/00 ,  A61K31/437

公开(公告)号：EP3274344B1

公开(公告)日：2019-04-24

申请号：EP16712081.5

申请日：2016-03-23

申请人： NOVARTIS AG

发明人： BUSCHMANN, Nicole ,  FAIRHURST, Robin Alec ,  FURET, Pascal ,  KNOEPFEL, Thomas ,  LEBLANC, Catherine ,  MAH, Robert

IPC分类号： C07D401/14 ,  C07D213/75 ,  C07D401/12 ,  A61K31/444 ,  A61K31/506 ,  A61P35/00 ,  C07D405/14 ,  A61K31/4427

公开(公告)号：EP3060563B1

公开(公告)日：2018-05-02

申请号：EP14806081.7

申请日：2014-10-24

申请人： Novartis AG

发明人： BUSCHMANN, Nicole ,  FAIRHURST, Robin Alec ,  FURET, Pascal ,  KNÖPFEL, Thomas ,  LEBLANC, Catherine ,  MAH, Robert ,  NIMSGERN, Pierre ,  RIPOCHE, Sebastien ,  LIAO, Lv ,  XIONG, Jing ,  ZHAO, Xianglin ,  HAN, Bo ,  WANG, Can

IPC分类号： C07D471/04 ,  C07D498/04 ,  C07D519/00 ,  A61K31/4375 ,  A61K31/437 ,  A61K31/4353 ,  A61K31/506 ,  A61K31/5383 ,  A61K31/5377 ,  A61K31/501 ,  A61P35/00

CPC分类号： C07D471/04 ,  A61K31/444 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/541 ,  A61K31/55 ,  C07D498/04 ,  C07D519/00

摘要： a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.

公开(公告)号：EP3273959A1

公开(公告)日：2018-01-31

申请号：EP16712083.1

申请日：2016-03-23

申请人： NOVARTIS AG

发明人： BUSCHMANN, Nicole ,  FAIRHURST, Robin Alec ,  FURET, Pascal ,  KNOEPFEL, Thomas ,  LEBLANC, Catherine ,  MAH, Robert ,  LIAO, Lv ,  XIONG, Jing ,  HAN, Bo ,  WANG, Can ,  GRAUS PORTA, Diana ,  ZHAO, Xianglin ,  WARTMANN, Markus ,  FORTANET, Jorge Garcia ,  HAFEEZ, Nafeeza ,  LAMARCHE, Matthew J. ,  PORTER, Dale

IPC分类号： A61K31/506 ,  A61K31/4439 ,  A61K31/513 ,  A61K31/519 ,  A61K31/5377 ,  A61P35/00

CPC分类号： A61K31/496 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K2300/00

摘要： A pharmaceutical combination comprising N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide, or a pharmaceutically acceptable salt thereof, and at least one active ingredient, as defined herein, or a pharmaceutically acceptable salt thereof, and optionally a pharmaceutically acceptable carrier, for simultaneous or sequential administration; the uses of such combination in the treatment of proliferative diseases; and methods of treating a subject suffering from a proliferative disease comprising administering a therapeutically effective amount of such combination.

公开(公告)号：EP2956455A1

公开(公告)日：2015-12-23

申请号：EP14707841.4

申请日：2014-02-11

申请人： Novartis AG

发明人： BUTLER, Rebecca ,  LEBLANC, Catherine ,  MCKEOWN, Stephen Carl ,  CHARLTON, Steven John

IPC分类号： C07D471/04 ,  A61K31/4375 ,  A61P7/02 ,  A61P9/10 ,  A61P11/06 ,  A61P3/10 ,  A61P29/00 ,  A61P19/04

CPC分类号： C07D471/04 ,  A61K31/4375

摘要： The present invention provides heterocyclic derivatives which activate the IP receptor. Activating the IP receptor signaling pathway is useful to treat many forms of PAH, pulmonary fibrosis and exert beneficial effects in fibrotic conditions of various organs in animal models and in patients. Pharmaceutical compositions comprising such derivatives are also encompassed.

公开(公告)号：EP2802582A1

公开(公告)日：2014-11-19

申请号：EP13705581.0

申请日：2013-01-11

申请人： Novartis AG

发明人： LEBLANC, Catherine ,  MCKEOWN, Stephen Carl ,  CHARLTON, Steven John ,  BHALAY, Gurdip ,  HEALY, Mark Patrick

IPC分类号： C07D471/04 ,  A61K31/4985 ,  A61P9/00 ,  A61P11/00

CPC分类号： C07D471/04 ,  A61K31/4985

摘要： The present invention provides heterocyclic derivatives which activate the IP receptor, processes for preparing them, pharmaceutical compositions comprising said derivatives and uses thereof. Activating the IP receptor signaling pathway is useful to treat many forms of PAH, pulmonary fibrosis and exert beneficial effects in fibrotic conditions of various organs in animal models and in patients. Formula (I):

公开(公告)号：EP1963322B1

公开(公告)日：2013-08-21

申请号：EP06841297.2

申请日：2006-12-07

申请人： Novartis AG

发明人： SANDHAM, David Andrew ,  LEBLANC, Catherine ,  BROWN, Lyndon Nigel

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P29/00

CPC分类号： C07D471/04

公开(公告)号：EP2242742A2

公开(公告)日：2010-10-27

申请号：EP09700450.1

申请日：2009-01-09

申请人： Novartis AG

发明人： ADCOCK, Claire ,  BAETTIG, Urs ,  HUNT, Peter ,  LEBLANC, Catherine ,  PIPET, Maude Nadine Pierrette ,  PULZ, Robert Alexander ,  SPIEGEL, Katrin ,  STIEFL, Nikolaus Johannes

IPC分类号： C07D213/74 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  A61K31/44 ,  A61K31/4427 ,  A61P35/00 ,  A61P25/00 ,  A61P19/00 ,  A61P9/00

CPC分类号： C07D405/14 ,  C07D213/74 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14

摘要： Compounds of formula (I) in free or salt or solvate form, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

公开(公告)号：EP1960398B1

公开(公告)日：2010-09-29

申请号：EP06819000.8

申请日：2006-12-07

申请人： Novartis AG

发明人： BROWN, Lyndon Nigel ,  LEBLANC, Catherine ,  SANDHAM, David Andrew ,  SINGH, Harinder Pal

IPC分类号： C07D471/04 ,  A61K31/435 ,  A61P29/00

CPC分类号： C07D471/04

摘要： There are provided according to the invention compounds of formula (I), in free or salt form, wherein R1, R2, R4, R5, R6, A, D, X, W, m and n are as described in the specification, process for preparing them, and their use as pharmaceuticals.

公开(公告)号：EP2044056A1

公开(公告)日：2009-04-08

申请号：EP07786024.5

申请日：2007-07-12

申请人： Novartis AG

发明人： LEBLANC, Catherine ,  PIPET, Maude, Nadine, Pierrette ,  FAIRHURST, Robin, Alec ,  ADCOCK, Claire ,  PULZ, Robert, Alexander ,  SHAW, Duncan ,  STIEFL, Nikolaus, Johannes

IPC分类号： C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  A61K31/435 ,  A61P9/00 ,  A61P11/00 ,  A61P29/00

CPC分类号： C07D401/14 ,  C07D405/14 ,  C07D413/14

摘要： Compounds of formula (I) in free or salt or solvate form, where T1, T2, Ra and Rb have the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.