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    COMBINATIONS COMPRISING EPOTHILONES AND PHARMACEUTICAL USES THEREOF
    1.
    发明授权
    COMBINATIONS COMPRISING EPOTHILONES AND PHARMACEUTICAL USES THEREOF 有权
    埃博霉素含组合及其药物用途

    公开(公告)号：EP1515750B1

    公开(公告)日：2010-08-11

    申请号：EP03757040.5

    申请日：2003-06-06

    申请人： Novartis AG ,  Novartis Pharma GmbH

    发明人： HOHNEKER, John, Arthur ,  MILLER, Julie, Ann ,  ROTHERMEL, John, David ,  WARTMANN, Markus

    IPC分类号： A61K45/06 ,  A61K31/426 ,  A61K31/427 ,  A61P35/00

    CPC分类号： C07K16/3015 ,  A61K31/426 ,  A61K31/427 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07D417/06 ,  A61K2300/00

    摘要： The invention relates to a pharmaceutical combination which comprises (a) a HER-1 or a HER-2 antibody or (b) at least one antineoplastic agent selected from the group consisting of aromatase inhibitors, antiestrogens, topoisomerase I inhibitors, topoisomerase II inhibitors, microtubule active agents, protein kinase C inhibitors, anti-angiogenic compounds, gonadorelin agonists, anti-androgens, histone deacetylase inhibitors and S-adenosyl-methionine decarboxylase inhibitors; and (c) an epothilone derivative of formula (I), and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular, for the treatment of a proliferative disease, especially a solid tumor disease; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of a medicament for the treatment of a proliferative disease; a commercial package or product comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and to a method of treatment of a warm-blooded animal, especially a human.

    COMBINATIONS COMPRISING EPOTHILONES AND PHARMACEUTICAL USES THEREOF
    8.
    发明公开
    COMBINATIONS COMPRISING EPOTHILONES AND PHARMACEUTICAL USES THEREOF 有权
    埃博霉素含组合及其药物用途

    公开(公告)号：EP1515750A1

    公开(公告)日：2005-03-23

    申请号：EP03757040.5

    申请日：2003-06-06

    申请人： Novartis AG ,  Novartis Pharma GmbH

    发明人： HOHNEKER, John, Arthur ,  MILLER, Julie, Ann ,  ROTHERMEL, John, David ,  WARTMANN, Markus

    IPC分类号： A61K45/06 ,  A61K39/395 ,  A61K31/426 ,  A61K31/427 ,  A61P35/00

    CPC分类号： C07K16/3015 ,  A61K31/426 ,  A61K31/427 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07D417/06 ,  A61K2300/00

    摘要： The invention relates to a pharmaceutical combination which comprises (a) a HER-1 or a HER-2 antibody or (b) at least one antineoplastic agent selected from the group consisting of aromatase inhibitors, antiestrogens, topoisomerase I inhibitors, topoisomerase II inhibitors, microtubule active agents, protein kinase C inhibitors, anti-angiogenic compounds, gonadorelin agonists, anti-androgens, histone deacetylase inhibitors and S-adenosyl-methionine decarboxylase inhibitors; and (c) an epothilone derivative of formula (I), and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular, for the treatment of a proliferative disease, especially a solid tumor disease; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of a medicament for the treatment of a proliferative disease; a commercial package or product comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and to a method of treatment of a warm-blooded animal, especially a human.