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公开(公告)号：EP2762155B1
公开(公告)日：2020-03-11
申请号：EP14000320.3
申请日：2014-01-29
发明人： Asari, Daisuke , Okubo, Katsuyuki , Shishido, Takuya , Okazaki, Arimichi , Maeda, Yoshiki , Matsushita, Kyohei , Li, Wenjing , Hori, Mitsuhiko , Sugiyama, Haruo
IPC分类号： A61K39/00
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公开(公告)号：EP2990030A1
公开(公告)日：2016-03-02
申请号：EP15002461.0
申请日：2015-08-19
IPC分类号： A61K9/00 , A61K38/00 , A61K47/36 , A61K9/20 , A61K9/70 , A61K31/48 , A61K31/7052 , A61K31/715 , A61K31/79
CPC分类号： A61K9/7007 , A23L33/13 , A23L33/17 , A23L33/175 , A23P10/00 , A61K9/00 , A61K9/0056 , A61K9/006 , A61K9/2054 , A61K9/70 , A61K9/7015 , A61K31/137 , A61K31/138 , A61K31/18 , A61K31/422 , A61K31/426 , A61K31/439 , A61K31/46 , A61K31/48 , A61K31/7052 , A61K31/715 , A61K31/79 , A61K38/00 , A61K47/10 , A61K47/183 , A61K47/32 , A61K47/36 , A61K47/38
摘要： The present invention aims to provide an oral film-form base and an oral film-form preparation which have a rapid dissolution profile in the mouth and sufficient film strength, give a good tactile impression when handled with fingers and favorable texture and taste in the mouth, and are administrable to those who have limitation in carbohydrate intake. The present invention relates to an oral film-form base including an edible polymer soluble in water and an organic solvent having a solubility parameter of 9.7 or higher, and particles of at least one compound selected from the group consisting of amino acid, dipeptide, and nucleotide, the particles of at least one compound selected from the group consisting of amino acid, dipeptide, and nucleotide being dispersed in the state of particles in the oral film-form base.
摘要翻译： 本发明的目的在于提供一种在口中具有快速溶出曲线并具有足够的膜强度的口腔膜形式基质和口腔膜形式制剂，在手指处理时具有良好的触觉，口中具有良好的质地和味道 ，并且对那些对碳水化合物摄入有限制的人可以进行治疗。 本发明涉及包含可溶于水的食用聚合物和溶解度参数为9.7以上的有机溶剂的口腔膜型基质，以及至少一种选自氨基酸，二肽和 核苷酸，选自氨基酸，二肽和核苷酸的至少一种化合物的颗粒以口腔膜形式的基质中的颗粒状态分散。
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公开(公告)号：EP2545904B1
公开(公告)日：2015-04-01
申请号：EP12005125.5
申请日：2012-07-11
CPC分类号： A61K9/0056 , A61K9/006 , A61K47/42
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公开(公告)号：EP2762154A3
公开(公告)日：2015-01-21
申请号：EP14000319.5
申请日：2014-01-29
发明人： Shishido, Takuya , Okubo, Katsuyuki , Asari, Daisuke , Okazaki, Arimichi , Maeda, Yoshiki , Matsushita, Kyohei , Li, Wenjing , Hori, Mitsuhiko , Sugiyama, Haruo
IPC分类号： A61K39/00
CPC分类号： A61K39/12 , A61K9/0014 , A61K9/06 , A61K9/7084 , A61K39/0011 , A61K39/39 , A61K47/32 , A61K47/34 , A61K2039/54 , A61K2039/55583
摘要： Disclosed is a vaccine composition for transdermal administration to induce cellular immunity, comprising an antigen, wherein Th1 cell ratio in a model animal for immunological evaluation that received the composition is 10% or more.
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45.发明公开WT1 peptide cancer vaccine composition for transdermal administration 审中-公开WT1 Peptid-enthaltender transdermaler Impfstoff gegen Krebs
公开(公告)号：EP2762159A1
公开(公告)日：2014-08-06
申请号：EP14000324.5
申请日：2014-01-29
发明人： Okubo, Katsuyuki , Maeda, Yoshiki , Okazaki, Arimichi , Asari, Daisuke , Shishido, Takuya , Hori, Mitsuhiko , Sugiyama, Haruo
IPC分类号： A61K39/00
CPC分类号： A61K9/0014 , A61K38/10 , A61K39/0011 , A61K2039/54
摘要： The present invention provides a cancer vaccine composition for transdermal administration for inducing cellular immunity, comprising (i) a WT1 peptide and/or a modified WT1 peptide; and (ii) a cellular immunity induction promoter. The composition efficiently induces cellular immunity against a cancer in a subject.
摘要翻译： 本发明提供用于诱导细胞免疫的经皮给药的癌症疫苗组合物，其包含（i）WT1肽和/或修饰的WT1肽; 和（ii）细胞免疫诱导启动子。 该组合物有效地诱导受试者中针对癌症的细胞免疫。
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46.发明公开Vaccine composition for transdermal or mucosal administration 审中-公开Impfstoffzusammensetzung zur transdermalen oder mukosalen Verabreichung
公开(公告)号：EP2762157A1
公开(公告)日：2014-08-06
申请号：EP14000322.9
申请日：2014-01-29
发明人： Maeda, Yoshiki , Okubo, Katsuyuki , Asari, Daisuke , Okazaki, Arimichi , Shishido, Takuya , Matsushita, Kyohei , Li, Wenjing , Hori, Mitsuhiko , Sugiyama, Haruo
CPC分类号： A61K9/0014 , A61K9/006 , A61K31/4745 , A61K31/739 , A61K38/10 , A61K39/0011 , A61K39/12 , A61K2039/54 , A61K2039/541 , A61K2039/55511 , A61K2039/55516 , A61K2039/55572 , C12N2770/24234
摘要： The invention provides a vaccine composition for transdermal or transmucosal administration for inducing cellular immunity, comprising (i) an antigen; and (ii) a pharmacologically acceptable acid or a pharmacologically acceptable salt thereof as a first cellular immunity induction promoter.
摘要翻译： 本发明提供一种用于经皮或经粘膜给药以诱导细胞免疫的疫苗组合物，其包含（i）抗原; 和（ii）药理学上可接受的酸或其药理学上可接受的盐作为第一细胞免疫诱导启动子。
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公开(公告)号：EP2524701A3
公开(公告)日：2012-12-19
申请号：EP12003909.4
申请日：2012-05-18
摘要： An object of the present invention is to provide a pharmaceutical composition that allows stable storage and delivery of heat-labile allergens. The present invention provides a pharmaceutical composition containing: an allergen; and at least one selected from the group consisting of an organic acid salt, an inorganic acid salt, and a pH adjuster.
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公开(公告)号：EP1270205B1
公开(公告)日：2004-03-31
申请号：EP02013288.2
申请日：2002-06-18
发明人： Hori, Mitsuhiko , Ninomiya, Kazuhisa , Matsuoka, Kensuke , Yamamoto, Keiji , Minomi, Kenjiro , Nakano, Yoshihisa
CPC分类号： B32B27/12 , A61F13/0206 , A61F13/0226 , A61F13/0253 , A61K9/7053 , A61K9/7061 , A61L15/26 , A61L15/44 , A61L15/58 , A61L2300/602 , B32B5/022 , B32B7/12 , C08L79/02 , C08L33/02
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50.发明公开Adhesive sheet and adhesive preparation, and production methods thereof 有权Klebefolie und Klebstoffzubereitung und Verfahren zur Herstellung
公开(公告)号：EP1270205A1
公开(公告)日：2003-01-02
申请号：EP02013288.2
申请日：2002-06-18
发明人： Hori, Mitsuhiko , Ninomiya, Kazuhisa , Matsuoka, Kensuke , Yamamoto, Keiji , Minomi, Kenjiro , Nakano, Yoshihisa
CPC分类号： B32B27/12 , A61F13/0206 , A61F13/0226 , A61F13/0253 , A61K9/7053 , A61K9/7061 , A61L15/26 , A61L15/44 , A61L15/58 , A61L2300/602 , B32B5/022 , B32B7/12 , C08L79/02 , C08L33/02
摘要： The present invention provides an adhesive sheet including a substrate consisting of a synthetic resin film and a nonwoven fabric laminated on one side of the film, and an adhesive layer formed on the nonwoven fabric, wherein the nonwoven fabric contains polyethyleneimine at least on a surface of the nonwoven fabric.
摘要翻译： 本发明提供一种粘合片，其包括由合成树脂膜和层叠在膜的一面上的无纺布构成的基材和形成在该无纺布上的粘合层，其中该无纺布至少在 无纺布。
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