摘要:
X-ray fluorescence (XRF) spectrometry has been used for detecting binding events and measuring binding selectivities between chemicals and receptors. XRF may also be used for estimating the therapeutic index of a chemical, for estimating the binding selectivity of a chemical versus chemical analogs, for measuring post-translational modifications of proteins, and for drug manufacturing.
摘要:
A chemical system for storing and releasing hydrogen utilizes an endothermic reaction that releases hydrogen coupled to an exothermic reaction to drive the process thermodynamically, or an exothermic reaction that releases hydrogen coupled to an endothermic reaction.
摘要:
A computer implemented method transforms an image (1A) comprised of pixels into a vectorized image specified by a plurality of polygons (1B) that can be subsequently used to aid in image processing and understanding. The pixelated image is processed to extract edge pixels (1C) that separate different colors and a constrained Delaunay triangulation of the edge pixels forms a plurality of triangles having edges that cover the pixelated image (1D). A color for each one of the plurality of triangles is determined from the color pixels within each triangle. A filter is formed with a set of grouping rules related to features of the pixelated image and applied to the plurality of triangle edges to merge adjacent triangles consistent with the filter into polygons having a plurality of vertices. The pixelated image may be then reformed into an array of the polygons, that can be represented collectively and efficiently by standard vector image.
摘要:
Fibers are spun from a supported array of nanotubes. Fibers are spun using a spinning shaft with, for example, a hook shaped end that contacts the supported nanotubes and twists some of them around each other to begin the fiber. As the twisted nanotubes detach from the support, the shaft moves away from and along the supported array in a controlled direction and at a controlled speed as it spins to twist and detach additional nanotubes from the support and extend the length of the fiber. If the array is pretreated with a dilute polymer solution, excess solution is squeezed out of the growing fiber during spinning, and the polymer may be cured at elevated temperature to provide a strong nanotube composite fiber.
摘要:
In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. In other embodiments, the immunogens comprise an immune modulating component.
摘要:
The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
摘要:
The invention is directed to HIV-1 envelope proteins and peptides, and compositions comprising the same to increase the breadth of vaccine coverage of the V1 V2 env region of clade C HIV-1.
摘要:
An antenna may include a volume polarization current radiator and a feed network. The volume polarization current radiator, includes a dielectric solid (such as a dielectric strip), and a plurality of closely-spaced excitation elements (24), each excitation element (24) being configured to induce a volume polarization current distribution in the dielectric solid proximate to the excitation element when a voltage is applied to the excitation element. The feed network is coupled to the volume polarization current radiator. The feed network also includes a plurality of passive power divider elements (32) and a plurality of passive delay elements (d1-d6) coupling the first port (30) and the plurality of second ports (108, 109, 164), the plurality of power divider elements (32) and the plurality of phase delay elements (d1- d6) being configured such that a radio-frequency signal that is applied to the first port (30) experiences a progressive change of phase as it is coupled to the plurality of second ports (108, 109, 164) so as to cause the volume polarization current distribution to propagate along the dielectric solid.
摘要:
The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).