摘要:
A pre-loaded delivery device (2) that facilitates accurate placement of a stent graft assembly (6) in the aorta is disclosed. A stent graft (6) is carried on the delivery device (2) and held in a pre-deployment configuration by a sheath (10). A split (13) in the sheath (10) facilitates the pre-cannulation of one or more branch arteries extending from the aorta before the stent graft (6) is fully released in the aorta. The stent graft (6) comprises a tubular body (32) having at least one scalloped fenestration (44) formed in one end of the graft material and at least one fenestration (42) formed in the graft material of the main tubular body (32). A helical internal side branch (56) extends from the fenestration (42) within the lumen of the main tubular body. The helical side branch (56) is configured to curve at least partially around the scalloped fenestration (44). The assembly further comprises a connection stent graft (54) extending from the fenestration (42) into a branch vessel.
摘要:
In a branch vessel prosthesis (20) comprising a graft (30), a stent (46) coupled to the proximal region of the graft, where the proximal region of the graft includes a generally straight configuration in an expanded deployed state that is substantially parallel to a longitudinal axis of a main vessel; and a stent (66) coupled to the distal region of the graft, where the distal region of the graft includes a generally straight configuration in the expanded deployed state that is substantially parallel to a branch vessel, there is provided an expansion member (55) coupled to the central region (50) of the graft, where the expansion member comprises a resilient pre-formed material that promotes a curvature of the central region in the expanded deployed state.
摘要:
System and methods are disclosed to facilitate intra-operative procedures and planning. A method can include storing tracking data in memory, the tracking data being generated by a tracking system to represent a location of an object in a tracking coordinate system of the tracking system. The method can also include storing a patient-specific implicit model in memory, the patient-specific implicit model being generated based on image data acquired for the patient to define geometry of an anatomical structure of the patient. The method can also include registering the tracking data and the patient-specific implicit model in a common three-dimensional coordinate system. The method can also include generating an output visualization representing a location of the object relative to the geometry of the anatomical structure of the patient in the common coordinate system.
摘要:
Provided are methods of treating a cardiomyopathy in a subject by administering directly to, or expressing locally in, a weakened, ischemic, and/or peri-infarct region of myocardial tissue of the subject an amount of stromal-cell derived factor-1 (SDF-1 ) effective to cause functional improvement in at least one of the following parameters: left ventricular volume, left ventricular area, left ventricular dimension, cardiac function, 6-minute walk test, or New York Heart Association (NYHA) functional classification. Also provided are methods of treating critical limb ischemia in a subject by administering a DNA plasmid encoding human SDF-1 by direct injection into the affected limb.
摘要:
The present invention relates a system that can detect a post-operative leak and a related method of use. An amylase detector that includes a sensor can detect a presence of amylase in a fluid secretion from an abdominal organ in a patient's body. The presence of amylase is indicative of the post-operative leak because, while amylase is common in the digestive tract, amylase is not normally found in the abdominal cavity. The amylase detector can alert a monitoring device external to the patient's body of the presence of amylase in the fluid secretion.
摘要:
The invention is directed to a method of treating a spinal cord injury, a neurodegenerative disease or a neuronal injury in an individual in need thereof comprising administering an effective amount of superoxide dismutase (SOD) and catalase to the individual, wherein the superoxide dismutase and the catalase are encapsulated in one or more nanoparticles that release the SOD and catalase upon administration. Another aspect of the invention is directed to compositions comprising superoxide dismutase (SOD) and catalase encapsulated in one or more nanoparticles.
摘要:
Systems and methods are provided for tracking a depth of a surgical instrument in an optical coherence tomography (OCT) guided surgical procedure. An OCT device (12) is configured to image a region of interest (14) to provide OCT data. A scan processor (16) is configured to determine a relative position of the instrument (18) and a target (20) within the region of interest from at least the OCT data, where the instrument is one of in front of the target, within the target, or below the target. A feedback element (22) is configured to communicate the relative position of the instrument and the target to a user in a human comprehensible form.