HYDROGELS WITH BIODEGRADABLE CROSSLINKING
    43.
    发明公开
    HYDROGELS WITH BIODEGRADABLE CROSSLINKING 有权
    水凝胶可生物降解的NETWORKING

    公开(公告)号:EP2755691A1

    公开(公告)日:2014-07-23

    申请号:EP12829900.5

    申请日:2012-09-07

    申请人: Prolynx LLC

    IPC分类号: A61K47/48

    摘要: Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals. This invention provides hydrogels that degrade to smaller, soluble components in a non-enzymatic process upon exposure to physiological conditions and to methods to prepare them. The hydrogels are prepared from crosslinking agents that undergo elimination reactions under physiological conditions, thus cleaving the crosslinking agent from the backbone of the hydrogel. The invention also relates to the crosslinking agents themselves and intermediates in forming the hydro gels of the invention. The biodegradable hydro gels prepared according to the methods of the invention may be of use in diverse fields, including biomedical engineering, absorbent materials, and as carriers for drug delivery.