A POLYGLYCOL MODIFIED CHITOSAN OLIGOSACCHARIDE FATTY ACID GRAFT, PREPARATION METHOD THEREOF AND USE OF THE SAME
    4.
    发明公开
    A POLYGLYCOL MODIFIED CHITOSAN OLIGOSACCHARIDE FATTY ACID GRAFT, PREPARATION METHOD THEREOF AND USE OF THE SAME 审中-公开
    聚合物 - 改性的CHITOSANOLIGOSACCHARID-FETTSÄUREPFROPFUNG,HERSTELLUNGSVERFAHREN UND VERWENDUNG

    公开(公告)号:EP2289946A1

    公开(公告)日:2011-03-02

    申请号:EP09765331.5

    申请日:2009-06-16

    摘要: The present invention provides a PEGylated and fatty acid grafted chitosan oligosaccharide comprising a structural unit represented by the following Formula (I) and a structural unit represented by the following Formula (II) and synthesize method, wherein the the chitosan oligosaccharide has a molecular weight of less than 200,000 Da, and a degree of deacetylation of 70%-100%, and part of free amino groups of chitosan oligosaccharide chain are replaced by a fatty acid or PEG, where n refers to degree of polymerization of the PEG, and R is an alkyl group having 11-21 carbon atoms. The grafting ratio of fatty acids is 1%-50%, and the grafting ratio of PEG is 0.05%-50%. The present invention also comprise a pharmaceutical composition comprising the PEGylated and fatty acid grafted chitosan oligosaccharide as a carrier, and use of the PEGylated and fatty acid grafted chitosan oligosaccharide in preparation of a pharmaceutical composition.

    摘要翻译: 本发明提供一种聚乙二醇化和脂肪酸接枝的壳聚糖寡糖,其包含由下式(I)表示的结构单元和由下式(II)表示的结构单元和合成方法,其中所述壳聚糖寡糖的分子量为 小于200,000Da,脱乙酰度为70%-100%,壳聚糖寡糖链的部分游离氨基被脂肪酸或PEG代替,其中n表示PEG的聚合度,R为 具有11-21个碳原子的烷基。 脂肪酸的接枝率为1%-50%,PEG的接枝率为0.05%〜50%。 本发明还包含一种包含聚乙二醇化和脂肪酸接枝的壳聚糖寡糖作为载体的药物组合物,以及聚乙二醇化和脂肪酸接枝的壳聚糖寡糖在制备药物组合物中的用途。