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    Hyperbranched polyglycerol sulfates with hydrophobic cores
    3.
    发明公开
    Hyperbranched polyglycerol sulfates with hydrophobic cores 审中-公开
    超氧化物聚甘油硫酸酯mit crowben Kernen

    公开(公告)号：EP2923695A1

    公开(公告)日：2015-09-30

    申请号：EP14161579.9

    申请日：2014-03-25

    申请人： DendroPharm GmbH

    发明人： Paulus, Florian ,  Haag, Rainer

    IPC分类号： A61K9/107 ,  C08G83/00

    CPC分类号： A61K9/0024 ,  A61K9/107 ,  A61K9/1075 ,  A61K31/704 ,  A61K47/60 ,  A61K47/6949 ,  C08G65/48 ,  C08G83/005 ,  C08G2650/02 ,  C08G2650/30 ,  C08G2650/38

    摘要： The present invention relates to the field of drug carrier systems and polymer therapeutics and diagnostics. It provides derivatized unimolecular polyols with a hydrophobic core moiety and a polyanionic, preferably, sulfated hydrophilic shell, in particular to unimolecular hyperbranched sulfated polyglycerol micelles having a hydrophilic shell and a hydophobic core. These may be used for the supramolecular encapsulation and transport of hydrophobic guest molecules into biological systems. The micelles can be applied as a drug carrier system for therapy and for diagnosis. They may also be therapeutic agents on their own. The invention also relates to preparation of said micelles.

    摘要翻译： 本发明涉及药物载体体系和聚合物治疗剂和诊断领域。 它提供具有疏水核心部分和聚阴离子，优选硫酸化的亲水壳的衍生的单分子多元醇，特别是具有亲水壳和疏水核的单分子超支化硫酸化聚甘油胶束。 这些可以用于超分子包封和将疏水客体分子运输到生物系统中。 胶束可用作药物载体系统用于治疗和诊断。 他们也可以自己治疗。 本发明还涉及所述胶束的制备。

    MULTI-ARM POLYETHYLENE GLYCOL DERIVATIVE, INTERMEDIATE THEREOF AND METHOD FOR PRODUCING SAME
    5.
    发明公开
    MULTI-ARM POLYETHYLENE GLYCOL DERIVATIVE, INTERMEDIATE THEREOF AND METHOD FOR PRODUCING SAME 有权
    多臂聚乙二醇，中间体AND METHOD FOR ITS

    公开(公告)号：EP2832765A1

    公开(公告)日：2015-02-04

    申请号：EP13768770.3

    申请日：2013-03-28

    申请人： NOF Corporation

    发明人： YOSHIOKA Hiroki ,  HIRAI Midori ,  NAKATSUHARA Hitoshi ,  YAMAMOTO Yuji

    IPC分类号： C08G65/329

    CPC分类号： C08G65/2609 ,  C08G65/2696 ,  C08G65/329 ,  C08G65/3322 ,  C08G65/33306 ,  C08G65/33337 ,  C08G65/33368 ,  C08G65/33389 ,  C08G2650/30

    摘要： Provided is a multi-arm polyethylene glycol derivative having a narrow molecular weight distribution. A multi-arm polyethylene glycol derivative represented by the formula (1):

    wherein, L represents a group selected from a linear or branched alkylene, arylene, or cycloalkylene group having two or more carbon atoms and combinations thereof, which may have an ether bond in a chain; X represents a dehydroxylation residue of a linear sugar alcohol having 5 or 7 carbon atoms; m is the number of polyethylene glycol chains bonded to X and represents 4 or 6; n is the average addition molar number of oxyethylene groups and n represents an integer of 3 to 600; Y represents a single bond or an alkylene group which may have an ester bond, a urethane bond, an amide bond, an ether bond, a carbonate bond, a secondary amino group, a urea bond, a thioether bond or a thioester bond in a chain or at an end; and Z represents a chemically reactive functional group.

    HYDROGELS WITH BIODEGRADABLE CROSSLINKING
    6.
    发明授权
    HYDROGELS WITH BIODEGRADABLE CROSSLINKING 有权

    公开(公告)号：EP2755691B1

    公开(公告)日：2018-08-22

    申请号：EP12829900.5

    申请日：2012-09-07

    申请人： Prolynx LLC

    发明人： ASHLEY, Gary, W. ,  SANTI, Daniel, V. ,  HENISE, Jeffrey, C.

    IPC分类号： A61L27/18 ,  A61L27/52 ,  A61K47/34 ,  C07C271/08 ,  A61L15/26 ,  A61K47/69 ,  A61K47/60

    CPC分类号： A61K47/34 ,  A61K47/60 ,  A61K47/6903 ,  A61L15/26 ,  A61L27/18 ,  A61L27/52 ,  C07C271/08 ,  C08G2650/30

    摘要： Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals. This invention provides hydrogels that degrade to smaller, soluble components in a non-enzymatic process upon exposure to physiological conditions and to methods to prepare them. The hydrogels are prepared from crosslinking agents that undergo elimination reactions under physiological conditions, thus cleaving the crosslinking agent from the backbone of the hydrogel. The invention also relates to the crosslinking agents themselves and intermediates in forming the hydro gels of the invention. The biodegradable hydro gels prepared according to the methods of the invention may be of use in diverse fields, including biomedical engineering, absorbent materials, and as carriers for drug delivery.