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622 条记录 (耗时 0.015 秒)

    Composition comprising indium for measuring trace amount of protein
    41.
    发明公开
    Composition comprising indium for measuring trace amount of protein 有权
    Indium-enthaltende Zusammensetzung zur Messung von Proteinspuren

    公开(公告)号：EP1014089A2

    公开(公告)日：2000-06-28

    申请号：EP99125529.0

    申请日：1999-12-22

    申请人： KYOTO DAIICHI KAGAKU CO., LTD.

    发明人： Kosaka, Hideko

    IPC分类号： G01N33/68

    CPC分类号： G01N33/683 ,  Y10S436/815

    摘要： A composition capable of showing a color change sufficient for indicating the presence and/or concentration of a protein in a protein-containing liquid sample by contacting with the sample, comprising: indium or an indium compound, and a dye or pigment capable of forming a complex with indium.

    摘要翻译： 一种能够显示足够的颜色变化的组合物，该颜色变化足以通过与样品接触来指示含蛋白质的液体样品中的蛋白质的存在和/或浓度，所述组合物包括：铟或铟化合物，以及能够形成 与铟复合。

    DETECTION OF DIOXIN-LIKE COMPOUNDS BY DETECTION OF TRANSFORMED Ah RECEPTOR/ARNT COMPLEX
    46.
    发明公开
    DETECTION OF DIOXIN-LIKE COMPOUNDS BY DETECTION OF TRANSFORMED Ah RECEPTOR/ARNT COMPLEX 失效
    二恶英类化合物通过确定经变换的Ah受体/ ARNT络合物测定

    公开(公告)号：EP0883810A1

    公开(公告)日：1998-12-16

    申请号：EP97907618.0

    申请日：1997-02-13

    申请人： PARACELSIAN, INC.

    发明人： WHEELOCK, Geoffrey, D.

    IPC分类号： G01N33

    CPC分类号： G01N33/567 ,  G01N33/5308 ,  G01N2333/705 ,  G01N2430/40 ,  Y10S436/815

    摘要： A method of detecting dioxin-like compounds consisting essentially of the group of compounds: polychlorinated dibenzodioxins, polychlorinated dibenzofurans, polychlorinated biphenyls, and structural analogues thereof which exhibit biological activity characteristic of polychlorinated dibenzodioxins, polychlorinated dibenzofurans, polychlorinated biphenyls. The assay includes: 1) an inactive Ah receptor in a form capable of binding to the dioxin-like compounds and being tranformed to an active form that forms a complex with ARNT and binds a dioxin responsive element, and 2) a quantity of ARNT sufficient to optimize Ah receptor transformation. A test sample is contacted with the assay under conditions effective to bind the dioxin-like compounds to the Ah receptor and allow transformation of the Ah receptor to an active form that forms a complex with ARNT. The presence of the complex containing the transformed Ah receptor and the ARNT is detected. The presence of the complex containing the transformed Ah receptor and the ARNT is detected with an antibody with a region capable of binding to the ARNT when associated with the complex.

    Calibrating and testing immunoassays to minimize interferences
    47.
    发明公开
    Calibrating and testing immunoassays to minimize interferences 失效
    Kalibrierung undPrüfungvon Immunoassays zur Verminderung vonStörungen

    公开(公告)号：EP0718626A3

    公开(公告)日：1998-06-10

    申请号：EP95309354

    申请日：1995-12-21

    申请人： JOHNSON & JOHNSON CLIN DIAG

    发明人： JACOBS MERRIT N ,  KILDAL-BRANDT PAUL A ,  ARTER THOMAS C

    IPC分类号： C12Q1/28 ,  G01N33/543 ,  G01N33/58 ,  G01N33/53

    CPC分类号： G01N33/54386 ,  G01N33/581 ,  Y10S435/962 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/815

    摘要： A method for reducing interferent bias such as hemoglobin bias in immunoassays using dried slide test elements featuring peroxidase and leuco dye as the labeling mechanism. The method features the steps of:

    a) calibrating an immunoassay of a target analyte by ascertaining the time at which the rate of change in density produced by a first set of the test elements for the target analyte on at least one liquid having a known amount of interferent of choice and a known amount of target analyte, crosses over or minimizes the difference compared to the rate of change in density produced by a second set of test elements substantially identical to the first set of test elements, on a liquid having the known amount of target analyte but a negligible amount of interferent of choice, and
    b) conducting an assay of a patient sample of unknown amount of the target analyte by reading the rate of change in density in a third set of the test elements substantially identical to the first and second sets, caused by the sample, at a time corresponding to the cross-over time ascertained in step a).

    摘要翻译： 使用以过氧化物酶和无色染料为特征的干燥载玻片测试元件作为标记机制，减少免疫测定中的血红蛋白偏差等干扰性偏倚的方法。 该方法具有以下步骤：a）通过确定由至少一种具有已知量的液体的目标分析物的第一组测试元件产生的密度变化率的时间来校准目标分析物的免疫测定 的选择干扰物和已知量的目标分析物，与具有基本上与第一组测试元件基本相同的第二组测试元件产生的密度变化率相比，与已知的量的目标分析物交叉或最小化 目标分析物的量，但是可选择的干扰物的量可忽略不计，以及b）通过读取第三组测试元件中的密度变化率来进行对未知量的目标分析物的患者样品的测定，其基本上与 在对应于在步骤a）中确定的交叉时间的时间，由样本引起的第一和第二组。

    Improved assay for aminoglycoside antibiotics
    48.
    发明公开
    Improved assay for aminoglycoside antibiotics 失效
    氨基糖苷 - 抗生素试验

    公开(公告)号：EP0786666A1

    公开(公告)日：1997-07-30

    申请号：EP97100730.7

    申请日：1997-01-17

    申请人： F. HOFFMANN-LA ROCHE AG

    发明人： Cheng, Charles Minnan

    IPC分类号： G01N33/94

    CPC分类号： G01N33/582 ,  G01N33/5306 ,  G01N33/9446 ,  Y10S436/815 ,  Y10S436/826

    摘要： The invention provides:

    a homogeneous immunochemical detection assay for the determination of aminoglycoside antibiotics in a biological sample, wherein said assay comprises the use of a water-soluble polycarboxylic acid polymer of general formula
       wherein

    R 1 is H or COOH,
    R 2 is H or CH 3
    and n is from 25 to 17,400, and

    an assemblage of reagents containing the above polycarboxylic polymer for performing such an assay.

    摘要翻译： 本发明提供了用于测定生物样品中氨基糖苷类抗生素的均质免疫化学检测测定法，其中所述测定法包括使用通式为CHEM的水溶性多元羧酸聚合物，其中R 1为H或COOH， R 2为H或CH 3，n为25至17,400，以及含有上述聚羧酸聚合物的试剂组合用于进行这种测定。

    IMMUNOASSAY FOR MYCOPHENOLIC ACID
    50.
    发明公开
    IMMUNOASSAY FOR MYCOPHENOLIC ACID 失效
    免疫测定为霉酚酸

    公开(公告)号：EP0769149A1

    公开(公告)日：1997-04-23

    申请号：EP95925364.0

    申请日：1995-06-29

    申请人： BEHRINGWERKE AG

    发明人： ALEXANDER, Svetlana ,  DAVALIAN, Dariush

    IPC分类号： G01N33 ,  C07D307 ,  C07K14 ,  C07K16 ,  C12N15 ,  C12P21

    CPC分类号： G01N33/9446 ,  C07D307/88 ,  C07K16/44 ,  G01N33/9493 ,  Y10S436/815

    摘要： The present invention provides antibodies useful in assays for mycophenolic acid (MPA). These antibodies bind MPA and are able to distinguish MPA from its esters, such as morpholineothyl E-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoate, and/or its metabolites, such as mycophenolic acid glucuronide. The present invention also provides conjugates of labels and MPA or MPA analogs. The antibodies of the invention are capable of binding these conjugates and are also capable of inhibiting the activity of the label when bound to the conjugates. The present invention also provides methods for the determination of MPA in a sample suspected of containing MPA that use the antibodies and/or conjugates of the invention. The present invention also provides assay reagents as well as packaged kits useful for performing the methods of the invention.