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    METHOD OF MONITORING PATIENT COMPLIANCE WITH MEDICATIONS PRESCRIPTIONS
    41.
    发明公开
    METHOD OF MONITORING PATIENT COMPLIANCE WITH MEDICATIONS PRESCRIPTIONS 失效
    VERFFAHREN FOR顺应性处方药物由患者监视

    公开(公告)号：EP0748444A4

    公开(公告)日：1997-08-27

    申请号：EP94931983

    申请日：1994-10-19

    申请人： KELL MICHAEL

    发明人： KELL MICHAEL

    IPC分类号： A61K49/00 ,  G01N33/15 ,  G01N33/493 ,  G01N33/53 ,  G01N33/70 ,  G01N33/94 ,  G01N31/00

    CPC分类号： G01N33/9486 ,  G01N33/493 ,  G06F19/3456 ,  Y02A90/26 ,  Y10S436/808 ,  Y10S436/816 ,  Y10S436/901 ,  Y10T436/173845

    摘要： A method of monitoring compliance of a patient that has been placed on a medication maintenance program with a prescribed medication dosage by determining a normalized urine medication concentration. An unadulterated urine sample is obtained from the patient. The urine medication concentration and urine specific gravity are measured. The normalized urine medication concentration is calculated as a function of the measured medication concentration in the urine and the urine specific gravity. The calculated normalized urine medication concentration is compared with an expected medication concentration value for the patient for the maintenance program prescribed to determine any significant differences therebetween as an indication of noncompliance. Alternatively, a urinary-parameter normalized urine medication concentration is calculated as a function of the measured medication concentration in the urine, the urine specific gravity and at least one selected pharmacokinetic parameter of the medication. The calculated urinary-parameter normalized urine medication concentration is compared with an expected medication concentration value for an average compliant patient for the maintenance program prescribed to determine any significant differences therebetween as an indication of noncompliance.

    Verfahren und Vorrichtung für den Nachweis von organischen Dämpfen und Aerosolen
    42.
    发明公开
    Verfahren und Vorrichtung für den Nachweis von organischen Dämpfen und Aerosolen 失效
    用于检测有机蒸汽和气溶胶的方法和设备

    公开(公告)号：EP0787985A1

    公开(公告)日：1997-08-06

    申请号：EP96101563.3

    申请日：1996-02-03

    申请人： CERBERUS AG

    发明人： Loepfe, Markus, Dr. ,  Wieser, Dieter ,  Ryser, Peter, Dr.

    IPC分类号： G01N27/62

    CPC分类号： G01N33/0047 ,  Y02A50/25 ,  Y10T436/17 ,  Y10T436/173076 ,  Y10T436/173845

    摘要： Bei einem Verfahren für den Nachweis von organischen Dämpfen und Aerosolen mittels Oberflächenionisation, insbesondere Aminen, Hydrazinen und stickstoffhaltigen Verbindungen, die aus Bränden entstehen, kondensieren die betreffenden Moleküle auf einer leitenden Vorrichtung (4). Diese wird durch Strompulse durch eine resistive Heizung (5) erhitzt, wodurch die kondensierten Moleküle thermisch ionisiert werden. Die erzeugten Ionen werden von einer Kollektorelektrode (9) aufgefangen und der resultierende Ionenstrompuls von einer Transimpedanzschaltung (15) verstärkt. Der Strompuls für die Erhitzung der leitenden Vorrichtung (4) dauert so lange an bis der Ionenstrompuls abgeklungen ist und die leitende Vorrichtung (4) von Restsubstanzen befreit ist. Dadurch bleibt die leitende Vorrichtung frei von Verschmutzung und verfügt über eine längere Lebensdauer. Die zeitgemittelte Leistungsaufnahme des Verfahrens beträgt weniger als 2 mW. Die leitende Vorrichtung (4) weist eine resistive, mäanderförmige Heizung (5) auf die als dünne Schicht auf einer Si 3 N 4 -Membran (3) aufgebracht ist, die über einer Öffnung (2) eines unterätzten Silizium-Chips (1) liegt. In einer weiteren Ausführungsform der leitenden Vorrichtung (4) ist auf der resistiven Heizung (5) eine durch eine Isolierschicht (7) beabstandete leitende Schicht (8) angeordnet.

    摘要翻译： 该方法对E. G.的薄膜（7）涉及上的导电涂层（8）的材料的缩合 氮化硅（Si3N4）由电阻弯曲元件（5）从下方加热。 其通过收集电极所捕获的冷凝分子（6）的加热器电流引起热电离的脉冲。 加热器电流脉冲被维持直到离子电流脉冲，这是由跨阻电路放大所有，已经衰减和导电涂层是从残基释放。 加热器沉积在置于在一个硅芯片（1）的标准晶片厚度的矩形开口（2）的Si3N4膜（3）。

    Method and kit for detecting explosives
    47.
    发明公开
    Method and kit for detecting explosives 失效
    Verfahren und Testsatz zum Nachweis von Sprengstoffen。

    公开(公告)号：EP0586125A2

    公开(公告)日：1994-03-09

    申请号：EP93306401.6

    申请日：1993-08-13

    申请人： State of Israel Represented by the Prime Minister's Office The Israel Institute for Biological Research

    发明人： Margalit, Yair

    IPC分类号： G01N31/22

    CPC分类号： G01N31/22 ,  F41H11/134 ,  F42B35/00 ,  G01N33/227 ,  Y10T436/17 ,  Y10T436/173076 ,  Y10T436/173845 ,  Y10T436/19

    摘要： In a method for detecting particular classes of explosives, a suspect sample is subjected serially to reagents (1), (2), (3) and (4) in the liquid phase, the reagents after the first being applied only if no color reaction has been obtained in the preceding test, while reagents (2) and (3) only are applied in presence of the preceding reagent(s). (1) is an alkaline solution of a diazotizable aminoaromatic azo-dye precursor (for nitroaromatic explosives). (2) is a strongly acidic reagent containing a nitrate to nitrite ion reducing agent and a diazo-coupler (for organic nitrates and nitramines). (3) is zinc powder suspended in a liquid comprising at least one water-miscible solvent (for inorganic nitrates). (4) is an aniline salt in a homogeneous strongly acidic solution including a water-miscible organic solvent (for chlorates and bromates). The invention includes also a test kit, as well as reagents (3) and (4), for use in the method.

    摘要翻译： 在用于检测特定类别的炸药的方法中，可疑样品在液相中连续进行试剂（1），（2），（3）和（4），只有在没有颜色反应 在上述试验中已经获得，而试剂（2）和（3）仅在前一试剂存在下使用。 （1）是可重氮氨基偶氮染料前体（用于硝基芳族炸药）的碱性溶液。 （2）是含有硝酸盐至亚硝酸根离子还原剂和重氮 - 偶合剂（对于有机硝酸盐和硝胺）的强酸性试剂。 （3）是悬浮在包含至少一种水混溶性溶剂（对于无机硝酸盐）的液体中的锌粉。 （4）是均匀强酸性溶液中的苯胺盐，其包括与水可混溶的有机溶剂（对于氯酸盐和溴酸盐）。 本发明还包括用于该方法的测试试剂盒以及试剂（3）和（4）。

    Aminoguanidine assay and applications thereof
    48.
    发明公开
    Aminoguanidine assay and applications thereof 失效
    氨基胍测定及其应用

    公开(公告)号：EP0448228A3

    公开(公告)日：1993-01-13

    申请号：EP91301370.2

    申请日：1991-02-20

    申请人： ALTEON INC.

    发明人： Ulrich, Peter C. ,  Look, Zee M.

    IPC分类号： G01N33/50 ,  G01N33/94

    CPC分类号： G01N33/66 ,  G01N33/5308 ,  G01N2800/52 ,  Y10S435/81 ,  Y10S436/808 ,  Y10T436/173845

    摘要： A method and associated materials including test kits for detecting and measuring the presence and amount of aminoguanidine and its analogs in biological samples is disclosed. Biological samples may include plasma, urine or tissue, and the present method may be used to determine the activity and effect of aminoguanidine and its analogs, particularly to the extent that such materials are useful as agents to prevent advanced glycosylation of proteins. The present invention extends to a new drug assay, suitable test kits, and to the assessment of kidney function and the potential to aid in the diagnosis of underlying pathologies where kidney dysfunction is a symptom.

    摘要翻译： 公开了一种方法和相关材料，包括用于检测和测量生物样品中氨基胍及其类似物的存在和量的测试试剂盒。 生物样品可以包括血浆，尿液或组织，本方法可用于测定氨基胍及其类似物的活性和作用，特别是在这些物质可用作预防蛋白质晚期糖基化的试剂时。 本发明延伸到新的药物测定，合适的测试试剂盒，以及肾功能的评估以及帮助诊断肾功能障碍是症状的潜在病理学的潜力。

    9-Anthrylalkyl compounds, their preparation and their use
    49.
    发明公开
    9-Anthrylalkyl compounds, their preparation and their use 失效
    9-ANTHRYLALKYL化合物，其制备及其用途

    公开(公告)号：EP0365495A3

    公开(公告)日：1991-10-16

    申请号：EP89850246.3

    申请日：1989-08-04

    申请人： Eka Nobel Aktiebolag

    发明人： Becker, Hans-Dieter ,  Einarsson, Stefan ,  Grzegorczyk, Andrzej ,  Josefsson, Björn ,  Lagerkvist, Stig Sören ,  Möller, Per Leopold ,  Sanchez, Domingo ,  Sörensen, Johan Henrik

    IPC分类号： C07C69/96 ,  C07C33/18

    CPC分类号： C07C69/96 ,  C07C33/18 ,  C07C227/34 ,  C07C2603/24 ,  Y10S435/968 ,  Y10T436/142222 ,  Y10T436/143333 ,  Y10T436/173845 ,  Y10T436/203332 ,  Y10T436/204998 ,  C07C229/36

    摘要： New 9-anthrylalkyl compounds having the general formula
    wherein R is hydrogen or an alkyl group, whereby, however, not more than one of the groups R is an alkyl group; R₁ is hydrogen, lower alkyl, halogen or nitro; n is an integer of from 1 to 7, whereby ,however, the total number of carbon atoms in the group -CHR-(CHR) n - does not exceed 8; and X is halogen, an azide group or a succinimidyl group. The new compounds are prepared from 9-anthrylalcohols which are reacted with a compound X-CO-X wherein X is a halogen, and then optionally with compounds giving azide or succinimidyl group. The compounds are used as derivatiza­tion reagents for separation and detection purposes. Intermediates for preparation of the above defined 9-anthrylalkyl compounds wherein one R is an alkyl group are 9-anthrylalcohols with the group -CHR-(CHR) n -OH, wherein one R is an alkyl group.

    摘要翻译： 具有通式的新的9-蒽基烷基化合物，其中R是氢或烷基，其中不超过一个基团R是烷基; R1是氢，低级烷基，卤素或硝基; n为1〜7的整数，但-CHR-（CHR）n-基团中的碳原子总数不超过8; X为卤素，叠氮基或琥珀酰亚胺基。 新化合物由与蒽化合物X-CO-X反应的9-蒽醇制备，其中X为卤素，然后任选与化合物给予叠氮化物或琥珀酰亚胺基。 该化合物用作分离和检测目的的衍生试剂。 用于制备上述定义的9-蒽基烷基化合物的中间体，其中一个R是烷基是具有基团-CHR-（CHR）n -OH的9-蒽基，其中一个R是烷基。

    Method for analysis of catecholamine
    50.
    发明公开
    Method for analysis of catecholamine 失效
    Verfahren zur分析von Catecholamin。

    公开(公告)号：EP0429082A2

    公开(公告)日：1991-05-29

    申请号：EP90122349.5

    申请日：1990-11-22

    申请人： HITACHI, LTD.

    发明人： Kamahori, Masao ,  Taki, Mamoru ,  Miura, Junkichi ,  Nogami, Taro ,  Watanabe, Yoshio

    IPC分类号： G01N33/50 ,  G01N33/58 ,  G01N33/74 ,  G01N30/02

    CPC分类号： G01N33/58 ,  G01N30/24 ,  G01N30/54 ,  G01N30/74 ,  G01N33/9453 ,  G01N2030/8804 ,  G01N2030/8813 ,  G01N2030/8822 ,  Y10T436/173845 ,  Y10T436/203332

    摘要： Catecholamines in a living body fluid are analyzed by a process comprising:
    reacting a living body fluid sample with a boron compound of the formula,

    wherein R is hydroxyl, aryl or alkyl,
    to form a complex of the boron compound with a catecholamine,
    deproteinizing the reaction solution containing the complex, and
    quantitatively determining the complex.
    The process makes it possible to measure catecholamines with a high recovery ratio and high accuracy, since catecholamines in a living body sample such as plasma, urine, etc., can be made insusceptible to the influence of the other substances in the living body samples, e.g. oxidation, by forming the catecholamines into a complex with a boron compound.

    摘要翻译： 通过以下方法分析活体液中的儿茶酚胺，其包括：使活体液样品与下式的硼化合物反应，其中R为羟基，芳基或烷基，形成硼化合物与儿茶酚胺的络合物 ，使含有络合物的反应溶液脱蛋白，并定量测定复合物。 该方法使得可以以高回收率和高精度测量儿茶酚胺，因为活体样品中的儿茶酚胺（例如血浆，尿等）可以被其他物质在活体样品中的影响所吸引， 例如 通过将儿茶酚胺形成与硼化合物的络合物来进行氧化。