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公开(公告)号：EP0283616B1
公开(公告)日：1991-07-24
申请号：EP87304279.0
申请日：1987-05-14
申请人： PLURICHEMIE ANSTALT
发明人： Heggie, William, Dr. , Page, Philip Ronald, Dr. , Villax, Ivan , Ghatak, Indira , Hursthouse, Michael Barry, Dr.
IPC分类号： B01J31/24 , B01J31/18 , C07C237/26
CPC分类号： B01J31/24 , B01J31/1805 , B01J31/2404 , B01J2231/641 , B01J2231/645 , B01J2531/822
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公开(公告)号：EP3873432B1
公开(公告)日：2022-11-23
申请号：EP19804637.7
申请日：2019-10-29
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公开(公告)号：EP3873432A1
公开(公告)日：2021-09-08
申请号：EP19804637.7
申请日：2019-10-29
发明人： KIESOW, Andreas , BUCHHOLZ, Mirko , SAREMBE, Sandra , MÄDER, Karsten , KIRCHBERG, Martin , EICK, Sigrun
IPC分类号： A61K9/00 , A61K9/14 , A61K31/65 , C07C237/26 , A61P31/04
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45.发明公开
公开(公告)号：EP3806865A1
公开(公告)日：2021-04-21
申请号：EP19820642.7
申请日：2019-06-13
IPC分类号： A61K31/65 , C07C237/26 , A61P25/32 , A61P25/36 , A61P31/00
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46.发明公开
公开(公告)号：EP3534908A1
公开(公告)日：2019-09-11
申请号：EP17867238.2
申请日：2017-10-31
IPC分类号： A61K31/65 , C07C237/26 , A61P31/04
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公开(公告)号：EP3493813A1
公开(公告)日：2019-06-12
申请号：EP17837652.1
申请日：2017-08-03
IPC分类号： A61K31/65 , A61P31/04 , C07C237/26
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公开(公告)号：EP3461808A1
公开(公告)日：2019-04-03
申请号：EP18187132.8
申请日：2001-06-29
发明人： NELSON, Mark. L. , FRECHETTE, Roger , VISKI, Peter , ISMAIL, Mohamed, Y. , BOWSER, Todd , DUMORNAY, Jimmy , RENNIE, Glen , LIU, Gui , KOZA, Darrell , SHEANAN, Paul , STAPLETON, Karen , HAWKINS, Paul , BHATIA, Beena , VERMA, Atul , HONEYMAN, Laura , WARCHOL, Ted
IPC分类号： C07C237/26 , A61K31/65
摘要： The present invention pertains, at least in part, to novel 9- substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
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公开(公告)号：EP2308832B1
公开(公告)日：2018-09-12
申请号：EP10182900.0
申请日：2001-06-29
发明人： Nelson, Mark L. , Frechette, Roger , Viski, Peter , Ismail, Mohamed Y , Bowser, Todd , Dumornay, Jimmy , Rennie, Glen , Liu, Gui , Koza, Darrell , Sheahan, Paul , Stapleton, Karen , Hawkins, Paul , Bhatia, Beena , Verma, Atul , McIntyre, Laura , Warchol, Ted
IPC分类号： C07C237/26 , A61K31/65 , A61P31/04 , A61P17/00
CPC分类号： A61K31/65 , C07C237/26 , C07C255/59 , C07C271/22 , C07C271/28 , C07C271/30 , C07C271/58 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C275/50 , C07C275/54 , C07C311/06 , C07C311/21 , C07C333/08 , C07C335/22 , C07C381/10 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2603/46 , C07D295/155 , C07F9/4006 , C07F9/4056 , Y02A50/473 , Y02A50/481
摘要： The present invention pertains, at least in part, to novel 9- substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
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公开(公告)号：EP3354637A1
公开(公告)日：2018-08-01
申请号：EP18155320.7
申请日：2016-02-12
IPC分类号： C07C237/26
CPC分类号： C07C237/26 , A61K31/65 , C07B2200/13
摘要： The present invention concerns new forms of crystalline minocycline base. In particular, two new crystalline polymorphic forms, designated Form IV and Form V of minocycline base are provided. These are characterized by XRD, FTIR and TGA. Processes for preparing the new polymorphic forms and their use in pharmaceutical compositions are also provided. Form IV and form V are prepared by dissolving and/or suspending minocycline base in an organic solvent followed by crystallization.
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