公开(公告)号：EP0088413A3

公开(公告)日：1984-04-04

申请号：EP83102187

申请日：1983-03-05

申请人： Takeda Chemical Industries, Ltd.

发明人： Furukawa, Yoshiyasu

IPC分类号： C07D498/04 ,  A61K31/505 ,  C07D261/00 ,  C07D239/00

CPC分类号： C07D498/04

摘要： Isoxazolo(3,4-d)pyrimidines of the formula
wherein R 1 and R 2 , respectively, are lower alkyl; R 3 is lower alkyl or acyl; and R 4 is hydrogen, lower alkyl, or acyl have antiinflammatory, analgesic and antipyretic activities in mammals and low acute and subacute toxicities, as well. The compounds are particularly useful as an antiinflammatory, analgesic and antipyretic drug.

公开(公告)号：EP0013111A3

公开(公告)日：1980-10-01

申请号：EP79302918

申请日：1979-12-17

申请人： MONSANTO COMPANY

发明人： Howe, Robert Kenneth ,  Liu, Kou Chang

IPC分类号： C07D498/10 ,  C07D261/08 ,  A01N43/90 ,  C07C135/00 ,  A01N43/74 ,  C07D307/00 ,  C07D261/00

CPC分类号： C07D261/08 ,  A01N43/90

摘要： 3'-(Substituted phenyl)-spiro (isobenzofuran-1(3H, 5'(4'H)-isoxazol -3-ones having the formula
wherein X and Y are independently selected from the group consisting of hydrogen, halogen, lower alkyl, lower alkoxy, halo-lower-alkyl, phenoxy, phenyl and cyano, their method of preparation as well as to their use as herbicides and plant growth regulants, especially for the regulation of soybeans. The use of the novel compounds as intermediates in the preparation of isoxazol -5-yl benzoates having the formula
wherein R is hydrogen or R'CH 2 - and R' is hydrogen or alkyl having up to four carbon atoms, inclusive, which are effective as herbicides and plant growth regulants.

公开(公告)号：EP3712139A1

公开(公告)日：2020-09-23

申请号：EP18879872.2

申请日：2018-11-16

申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd. ,  Medshine Discovery Inc.

发明人： WU, Lifang ,  SUN, Fei ,  DU, Jinhua ,  DING, Charles Z. ,  CHEN, Shuhui ,  ZHANG, Xiquan ,  XU, Hongjiang ,  YANG, Ling

IPC分类号： C07D261/00 ,  C07D413/12 ,  C07D413/14 ,  C07D498/04 ,  A61K31/424 ,  A61K31/4355 ,  A61K31/437 ,  A61P31/12

摘要： Disclosed are a class of anti-HBV tetrahydroisoxazolo[4,3-c]pyridine compounds and pharmaceutically acceptable salts thereof or isomers thereof, the compounds being represented by the formula (I).

公开(公告)号：EP3431464A3

公开(公告)日：2019-07-31

申请号：EP18191450.8

申请日：2004-08-06

申请人： Senomyx Inc.

发明人： TACHDJIAN, Catherine ,  PATRON, Andrew, P. ,  ADAMSKI-WERNER, Sara, L. ,  BAKIR, Farid ,  CHEN, Qing ,  DARMOHUSODO, Vincent ,  ROGERS, Daniel, Harry ,  LI, Xiadong ,  QI, Ming, Cai Lun Lu ,  ROGERS, Daniel, Harry ,  LEBL-RINVOA, Marketa ,  SERVANT, Guy ,  TANG, Xiao-Qing ,  ZOLLER, Mark ,  WALLACE, Mark ,  XING, Amy ,  GUBERNATOR, Klaus

IPC分类号： C07C275/30 ,  C07C275/34 ,  C07C233/65 ,  C07C235/54 ,  C07D317/68 ,  C07D307/84 ,  G01N33/566 ,  G01N33/74 ,  C07D307/34 ,  C07D333/02 ,  C07D221/00 ,  C07D247/00 ,  C07D261/00 ,  C07D283/00 ,  A23L27/20

摘要： The present invention relates to the discovery that certain non-naturally occurring, non-peptide arride compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or trite enhancer, more particularly, savory (the "umami" taste of monosodium glutamate) or sweet taste modifiers, - savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.

公开(公告)号：EP3319944A1

公开(公告)日：2018-05-16

申请号：EP16824979.5

申请日：2016-07-11

申请人： Arvinas, Inc.

发明人： CREW, Andrew, P. ,  CREWS, Craig, M. ,  DONG, Hanqing ,  QIAN, Yimin ,  WANG, Jing

IPC分类号： C07D223/00 ,  C07D231/12 ,  C07D261/00 ,  G01N33/50 ,  G01N33/53

CPC分类号： C07D495/14 ,  A61K31/337 ,  A61K31/4184 ,  A61K31/436 ,  A61K31/4545 ,  A61K31/4995 ,  A61K31/506 ,  A61K31/593 ,  A61K31/664 ,  A61K31/704 ,  A61K45/06 ,  A61K47/55 ,  C07D207/16 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D417/12 ,  A61K2300/00

摘要： The description relates to MDM2 binding compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the description provides compounds, which contain on one end a ligand which binds to the MDM2 E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.

公开(公告)号：EP2445868B1

公开(公告)日：2013-12-18

申请号：EP10725188.6

申请日：2010-06-18

申请人： F.Hoffmann-La Roche AG

发明人： BROKA, Chris Allen ,  HAWLEY, Ronald Charles

IPC分类号： C07C237/42 ,  C07D213/00 ,  C07D233/00 ,  C07D241/00 ,  C07D261/00 ,  C07D263/00 ,  C07D265/00 ,  C07D277/00 ,  C07D285/00 ,  C07D307/00 ,  C07D309/00 ,  C07D333/00 ,  C07D231/00 ,  C07D305/00 ,  A61K31/166 ,  A61K31/33

CPC分类号： C07D241/12 ,  C07C237/32 ,  C07C237/42 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07D213/56 ,  C07D213/61 ,  C07D213/81 ,  C07D231/14 ,  C07D241/24 ,  C07D261/18 ,  C07D263/34 ,  C07D265/30 ,  C07D277/56 ,  C07D285/06 ,  C07D295/125 ,  C07D307/68 ,  C07D309/08 ,  C07D333/38 ,  C07D401/12 ,  C07D403/12 ,  C07D405/14 ,  C07D417/12

摘要： Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted phenyl or optionally substituted pyridinyl, and R2, R3, R4, R5, R6, R7, R8 and R9 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.

摘要翻译： 式I化合物或其药学上可接受的盐，其中，R 1是任选取代的苯基或任选取代的吡啶基，且R 2，R 3，R 4，R 5，R 6，R 7，R 8和R 9如本文所定义。 还公开了使用该化合物治疗与P2X3和/或P2X2 / 3受体拮抗剂相关疾病的方法和制备该化合物的方法。

公开(公告)号：EP2187748A2

公开(公告)日：2010-05-26

申请号：EP08842127.6

申请日：2008-10-23

申请人： E. I. du Pont de Nemours and Company

发明人： GREGORY, Vann ,  PASTERIS, Robert, James

IPC分类号： A01P3/00 ,  A01N43/78 ,  A01N43/80 ,  C07D261/00 ,  C07D277/00 ,  A01N43/40 ,  A01N43/56 ,  A01N43/653 ,  A01N43/90

CPC分类号： A01N43/90 ,  A01N43/40 ,  A01N43/56 ,  A01N43/653 ,  A01N43/78 ,  A01N43/80 ,  C07D413/14 ,  C07D417/14 ,  A01N37/34 ,  A01N37/36 ,  A01N37/46 ,  A01N37/50 ,  A01N43/42 ,  A01N43/50 ,  A01N43/54 ,  A01N43/76 ,  A01N47/04 ,  A01N47/12 ,  A01N47/14 ,  A01N47/24 ,  A01N47/34 ,  A01N57/12 ,  A01N59/20 ,  A01N2300/00

摘要： Disclosed is a fungicidal composition comprising (a) at least one compound selected from the compounds of Formula 1 N-oxides, and salts thereof, wherein R1, R2, A, G, W, Z1, X, J, and n are as defined in the disclosure, and (b) at least one additional fungicidal compound. Also disclosed is a method for controlling plant diseases caused by fungal plant pathogens comprising applying to the plant or portion thereof, or to the plant seed, a fungicidally effective amount of the aforesaid composition. Also disclosed is a composition comprising component (a) of aforesaid composition and at least one insecticide. Also disclosed are compounds of Formula 1A, 1B and 1C, wherein R1, R2, A, G, W, Z1, X, J, n, Z3, M and J1are as defined in the disclosure.

摘要翻译： 公开了一种杀真菌组合物，其包含（a）至少一种选自式1化合物的化合物及其盐的化合物，其中R 1，R 2，A，G，W，Z 1，X，J和n如上定义 在本公开中，和（b）至少一种额外的杀真菌化合物。 还公开了一种控制由真菌植物病原体引起的植物病害的方法，包括向植物或其部分或植物种子施用杀真菌有效量的上述组合物。 还公开了包含上述组合物的组分（a）和至少一种杀虫剂的组合物。 还公开了式1A，1B和1C的化合物，其中R1，R2，A，G，W，Z1，X，J，n，Z3，M和J1如本公开所定义。

公开(公告)号：EP1902038A2

公开(公告)日：2008-03-26

申请号：EP06776077.7

申请日：2006-06-24

申请人： BAYER CROPSCIENCE AG

发明人： SCHAPER, Wolfgang ,  HELMKE, Hendrik

IPC分类号： C07D261/00

CPC分类号： C07D261/04 ,  C07D261/08 ,  C07D413/12

摘要： The invention relates to a method for producing 3-arylmethylthio- and 3-heteroarylmethylthio-4,5-dihydro-isoxazoline derivatives of general formula (I), by means of a one-pot reaction wherein corresponding arylmethyl and heteroarylmethyl-isothiuronium salts are reacted in the presence of an aqueous alkali or earth alkali base with an isoxazoline derivative in order to form the corresponding 3-arylmethylthio- and 3-heteroarylmethylthio-4,5-dihydro-isoxazoline derivatives.

公开(公告)号：EP1781673A1

公开(公告)日：2007-05-09

申请号：EP05771781.1

申请日：2005-08-16

申请人： AstraZeneca AB

发明人： AQUILA, Brian AstraZeneca R & D Boston ,  BLOCK, Michael, Howard AstraZeneca R & D Boston ,  DAVIES, Audrey AstraZeneca R & D Boston ,  EZHUTHACHAN, Jayachandran AstraZeneca R & D Boston ,  PONTZ, Timothy AstraZeneca R & D Boston ,  RUSSELL, Daniel, John AstraZeneca R & D Boston ,  THEOCLITOU, Marie-Elena AstraZeneca R & D Boston ,  ZHENG, XiaoLan AstraZeneca R & D Boston

IPC分类号： C07D513/04 ,  C07D498/04 ,  A61K31/519 ,  A61P35/00 ,  C07D275/00 ,  C07D239/00 ,  C07D261/00

CPC分类号： C07D513/04

摘要： This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.

公开(公告)号：EP1450800A4

公开(公告)日：2005-12-07

申请号：EP02791349

申请日：2002-11-26

申请人： SQUIBB BRISTOL MYERS CO

发明人： QUAN MIMI L ,  WEXLER RUTH R

IPC分类号： A61P7/02 ,  C07D401/12 ,  C07D403/12 ,  C07D413/14 ,  C07D471/04 ,  A61K31/415 ,  A61K31/42 ,  A61K31/44 ,  A61K31/445 ,  C07D231/00 ,  C07D261/00 ,  C07D401/00

CPC分类号： C07D401/12 ,  C07D403/12 ,  C07D413/14 ,  C07D471/04

摘要： The present application describes substituted-aminomethyl substituted compounds and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.