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    RAPID RELEASE MINI-TABLETS PROVIDE ANALGESIA IN LABORATORY ANIMALS
    41.
    发明公开
    RAPID RELEASE MINI-TABLETS PROVIDE ANALGESIA IN LABORATORY ANIMALS 审中-公开
    快速释放的MINI片中启用镇痛实验室动物

    公开(公告)号：EP2089010A1

    公开(公告)日：2009-08-19

    申请号：EP07844490.8

    申请日：2007-10-22

    申请人： The John Hopkins University

    发明人： GUARNIERI, Michael

    IPC分类号： A61K31/00 ,  A61K31/20 ,  A61K31/48 ,  A61K31/4468 ,  A61K31/445 ,  A61K31/245 ,  A61K9/20 ,  A61K47/44

    CPC分类号： A61K31/20 ,  A61K9/0024 ,  A61K9/2072 ,  A61K31/245 ,  A61K31/4468 ,  A61K31/48 ,  A61K31/485

    摘要： Pellets containing an analgesic uniformly dispersed in a lipid carrier such as cholesterol mixed with fatty acid esters, can be used to provide long term pain relief. 5 mg cholesterol-tryglyceride- buprenorphine pellets released the majority of drug in 24-48 hours after implant and provide clinically significant plasma levels of analgesia in mice for 3-9 days. Blood levels of analgesia peak at day-1 and are substantially complete by day-5 depending on the level of buprenorphine. These results demonstrate that post surgical implants provide clinically significant levels of analgesia in the 24-48 hour period following surgery and thus obviate the time consuming, expensive, and high-risk need to inject mice post surgery. The pellets are safe and easy to use. Placed in the surgical wound at the end of surgery, they provide 2-3 days of analgesia and obviate the need for subsequent handling of the animal for pain therapy. The implants have no detectable effect on mouse behavior, hematology, or liver chemistry. The unexpected release kinetics of the 5 mg pellet provides an ideal implant for post surgical analgesia. These implants solve a significant problem facing scientists who use rodents in research and abide by international of animal welfare.

    METHOD AND COMPOSITION FOR TREATING AND DIAGNOSING RESTLESS LEGS SYNDROME
    44.
    发明公开
    METHOD AND COMPOSITION FOR TREATING AND DIAGNOSING RESTLESS LEGS SYNDROME 审中-公开
    方法和组合物可用于治疗和诊断综合征和平地段支脚的

    公开(公告)号：EP1973551A1

    公开(公告)日：2008-10-01

    申请号：EP06824619.8

    申请日：2006-12-06

    申请人： Cereuscience AB

    发明人： GROTE, Ludger ,  HEDNER, Jan ,  STENLÖF, Kaj

    IPC分类号： A61K33/26 ,  A61K31/135 ,  A61K31/137 ,  A61K31/198 ,  A61K31/4045 ,  A61K31/428 ,  A61K31/48 ,  A61P25/00

    CPC分类号： A61K31/428 ,  A61K31/135 ,  A61K31/137 ,  A61K31/198 ,  A61K31/4045 ,  A61K31/48 ,  A61K33/26 ,  A61K2300/00

    摘要： A method of treating Restless Legs Syndrome (RLS) comprises the joint administration of an agent selected from dopamine turnover increasing agent and dopaminergic receptor exciting agent, in particular pramipexole, and iron in a biologically usable form, in pharmacologically effective combined amounts. Also disclosed is a corresponding use; a pharmaceutical composition comprising an agent selected from dopamine turnover increasing agent and dopaminergic receptor exciting agent, in particular pramipexole, and iron in a biologically usable form, and a pharmaceutically acceptable carrier; a package comprising a pharmaceutical composition for per-oral administration comprising an agent selected from dopamine turnover increasing agent and dopaminergic receptor exciting agent and a pharmaceutically acceptable carrier and a pharmaceutical composition for per-oral administration comprising iron in a biologically usable form and a pharmaceutical acceptable carrier.