公开(公告)号：EP0241295B1

公开(公告)日：1992-08-12

申请号：EP87303114.0

申请日：1987-04-09

申请人： Masuhara, Eiichi

发明人： Masuhara, Eiichi ,  Hosoda, Hiroyasu

IPC分类号： A61K6/00 ,  A61K31/00 ,  A61K31/78

CPC分类号： A61K31/60 ,  A61K6/0017 ,  A61K6/0023 ,  A61K6/0052 ,  A61K31/78 ,  Y10S514/817 ,  C08L33/10

公开(公告)号：EP0429156A1

公开(公告)日：1991-05-29

申请号：EP90300327.5

申请日：1990-01-11

申请人： COLUMBIA LABORATORIES, INC.

发明人： Robinson, Joseph R.

IPC分类号： A61K7/48 ,  A61K47/32 ,  A61K31/78 ,  A61K9/06

CPC分类号： A61Q19/007 ,  A61K8/8117 ,  A61K8/8147 ,  A61K8/817 ,  A61K8/8194 ,  A61K31/765 ,  A61K31/78 ,  A61Q11/00 ,  A61Q19/00

摘要： A method of moisturizing mammalian skin membranous tissue is disclosed. The composition utilized in this method includes a bioadhesive polymer as the moisturizing agent. The bioadhesive is a water-­swellable, but water-insoluble, particulate, fibrous, cross-linked carboxy-functional polymer containing (a) a plurality of repeating units of which at least about 80 percent contain at least one carboxyl functionality, and (b) about 0.05 to about 1.5 percent cross-linking agent substantially free from polyalkenyl polyether. The composition is contacted with the skin or mucous membrane to be moisturized, and that contact is maintained for a time period sufficient to moisturize the contacted area.

摘要翻译： 公开了一种滋润哺乳动物皮肤膜组织的方法。 在该方法中使用的组合物包括生物粘附聚合物作为保湿剂。 生物粘附剂是水溶胀性但水不溶性的颗粒状纤维交联羧基官能聚合物，其含有（a）多个重复单元，其至少约80％含有至少一个羧基官能团，和（b ）约0.05至约1.5％的交联剂基本上不含聚烯基聚醚。 将组合物与皮肤或粘膜接触以进行保湿，并将该接触保持一段足以保湿接触区域的时间。

公开(公告)号：EP0298121A4

公开(公告)日：1991-01-30

申请号：EP87902189

申请日：1987-01-14

申请人： VSESOJUZNY NAUCHNO-ISSLEDOVATELSKY I ISPYTATELNY INSTITUT MEDITSINSKOI TEKHNIKI ,  MOSKOVSKY NAUCHNO-ISSLEDOVATELSKY ONKOLOGICHESKY INSTITUT IMENI P.A. GERTSENA

发明人： AKIMOVA, ALLA YAKOVLEVNA ,  DAVYDOV, ANATOLY BORISOVICH ,  EGIEV, VALERY NIKOLAEVICH ,  ILIINA, ANNA IVANOVNA ,  KAPUSTIN, JURY PAVLOVICH ,  ORFANIDI, ANESTY KHRISTOVICH ,  SMIRNOV, ALEXEI NIKOLAEVICH ,  STEPANOV, EDUARD ALEXANDROVICH ,  TIMOKHINA, VALERIA IOSIFOVNA ,  CHIGIR, ANATOLY NIKOLAEVICH ,  SCHITKOV, KIRILL GEORGIEVICH

IPC分类号： A61K31/78 ,  A61L24/06 ,  A61L26/00 ,  A61L27/00 ,  A61P17/00 ,  A61P43/00 ,  A61L15/00 ,  A61L15/01

CPC分类号： A61L24/06 ,  A61L26/0014 ,  Y10S623/92 ,  C08L51/06 ,  C08L35/04

摘要： A biocompatible material for treatment of defects in tissues and organs consists of a graft copolymer of alpha-cyanacrylate with the polyacryl acid with a molar mass of 200,000-600,000, obtained by interaction of alpha-cyanacrylate with the polyacryl acid in the presence of a cross-linking agent in the following ratio of the said components in percent by weight: alpha-cyanacrylate - 14-34, polyacryl acid with molar mass of 200,000-600,000 - 15-43, cross-linking agent - 71-23.

公开(公告)号：EP0365613A4

公开(公告)日：1990-09-05

申请号：EP89903311

申请日：1989-03-09

申请人： ALCON LABORATORIES INC

发明人： CAGLE, GERALD, D. ,  MCDONALD, THOMAS, O. ,  ROSENTHAL, ALLAN, L.

IPC分类号： A61K31/57 ,  A61K9/06 ,  A61K9/08 ,  A61K31/35 ,  A61K31/56 ,  A61K31/70 ,  A61K31/74 ,  A61K31/78 ,  A61P27/02 ,  A61P29/00 ,  A61K31/71

CPC分类号： A61K31/70 ,  A61K31/57 ,  A61K2300/00

公开(公告)号：EP0351987A1

公开(公告)日：1990-01-24

申请号：EP89306864.3

申请日：1989-07-06

申请人： RECKITT AND COLMAN PRODUCTS LIMITED

发明人： Lloyd-Jones, John Gareth ,  Dettmar, Peter William

IPC分类号： A61K31/78

CPC分类号： A61K31/78 ,  A61K31/74 ,  C08L33/02

摘要： The use of polyacrylates for the manufacture of a medicament for the treatment of inflammatory bowel disease. Preferably the polyacrylate is carbomer or its sodium salt and most preferably carbomer 934P or its sodium salt. The medicaments may be administered orally or rectally, as appropriate, according to the site of the disease.

摘要翻译： 使用聚丙烯酸酯制造用于治疗炎症性肠病的药物。 优选地，聚丙烯酸酯是卡波姆或其钠盐，最优选卡波姆934P或其钠盐。 药物可以根据疾病的部位酌情口服或直肠给药。

公开(公告)号：EP0169684A3

公开(公告)日：1989-01-18

申请号：EP85304907.0

申请日：1985-07-10

申请人： RECKITT AND COLMAN PRODUCTS LIMITED

发明人： Dettmar, Peter William

IPC分类号： A61K31/195 ,  A61K31/78 ,  A61K33/00

CPC分类号： A61K31/78 ,  A61K33/00 ,  A61K31/195 ,  A61K2300/00

摘要： Pharmaceutical compositions comprising mixtures of proglumide and polyacrylic acid or their sodium salts in a specified range of ratios have been found to exhibit synergistic effects in an in vivo test model for anti-ulcer or mucosal-protecting agents. Pharmaceutical compositions comprising mixtures of proglumide and polyacrylic acid or their sodium salts in the range of ratios are described for use in the treatment of gastritis or of gastro-duodenal ulcers.

摘要翻译： 已经发现包含特定范围的丙酮酸和聚丙烯酸或其钠盐的混合物的药物组合物在抗溃疡或粘膜保护剂的体内试验模型中表现出协同效应。 描述了包含丙烯酸和聚丙烯酸或其钠盐的比例范围的混合物的药物组合物用于治疗胃炎或胃十二指肠溃疡。

公开(公告)号：EP0136006A3

公开(公告)日：1988-07-27

申请号：EP84305124

申请日：1984-07-27

申请人： RECKITT AND COLMAN PRODUCTS LIMITED

发明人： Dettmar, Peter William

IPC分类号： A61K31/78 ,  A61K31/225

CPC分类号： A61K31/78 ,  A61K31/225 ,  A61K2300/00

摘要： Pharmaceutical compositions comprising mixtures of sodium polyacrylate and carbenoxolone sodium in a specified range of ratios have been found to exhibit synergistic effects in an in vivo test model for anti-ulcer or mucosal-protecting agents. Pharmaceutical compositions comprising mixtures of sodium polyacrylate and carbenoxolone in the range of ratios are described for use in the treatment of gastritis or of gastro-duodenal ulcers.

公开(公告)号：EP0103184A3

公开(公告)日：1985-06-19

申请号：EP83107973

申请日：1983-08-11

申请人： Diamond Shamrock Chemicals Company

发明人： Jarrett, Robert D. ,  McCain, Howard G.

IPC分类号： A61K47/00 ,  C08J07/12 ,  C08B15/00 ,  A61M01/03 ,  B01D15/00 ,  A61K31/72 ,  A61K31/78 ,  A61K31/785 ,  A61K31/79

CPC分类号： A61M1/3687 ,  A61K35/14 ,  A61K47/58 ,  A61K47/6883

摘要： @ Biocompatible polymers containing immobilized biologicals which retain a high specificity for binding-pathological effectors or specific groups of pathological effectors are disclosed.

公开(公告)号：EP0029844B1

公开(公告)日：1984-12-05

申请号：EP80901238.8

申请日：1980-06-05

申请人： HOLLES LABORATORIES, INC.

发明人： HOLLY, Frank J.

IPC分类号： A61K9/08 ,  A61K31/70 ,  A61K31/74 ,  A61K31/78

CPC分类号： A61K9/0048

摘要： An ophthalmic solution for treating corneal edema concurrent with epithelial discontinuity, healing epithelial defects, and protecting against epithelial trauma containing electrolytes at only isotonic levels but containing hydrophilic macromolecules at such concentration that their colloidal osmotic pressure is equal or greater that the imbibition pressure of corneal stroma.

公开(公告)号：EP0093489A2

公开(公告)日：1983-11-09

申请号：EP83301268.5

申请日：1983-03-08

申请人： RICHTER GEDEON VEGYESZETI GYAR R.T.

发明人： Machovich, Raymund, Dr. ,  Nagy, Miklos, Dr. ,  Gyorgyi, Judit, Dr. ,  Horvath, Istvan, Dr. ,  Low, Miklos ,  Csomor, Katalin ,  Karpati, Egon, Dr. ,  Szporny, Laszlo, Dr. ,  Kisfaludy, Lajos, Dr.

IPC分类号： C08F220/00 ,  C08F8/44 ,  A61K31/78

CPC分类号： C08F228/00 ,  A61K31/78 ,  A61K31/795 ,  A61L33/064 ,  C08F220/04 ,  A61K31/74 ,  C08L33/00 ,  C08L29/04

摘要： The invention relates to new, pharmaceutically active copolymers with heparin-like activity, pharmaceutically acceptable salts thereof and a process for their preparation. The new copolymers comprising the units of the general formula /I/
derived from /meth/acrylic acid or an ester thereof /X stands for hydrogen or methyl and Y is hydrogen/, units of the formula /III/
optionally units of the general formula /II/
/Z' is hydrogen/, and chain terminating units, formed from the units of the formulae /I/, /III/ and optionally /II/ under the conditions of copolymerization, in a statistical arrangement, and the pharmaceutically acceptable salts thereof, which contain, in addition to the above chain-members, units of the general formulae /IV/ and/or /V/

/X has the same meaning as defined above, and A is a cation/ satisfactorily replace the organogenic heparin, or give a synergistic combination with that.