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    Carbamic acid derivatives and method for preparing the same
    46.
    发明公开
    Carbamic acid derivatives and method for preparing the same 失效
    Carbaminsäurederivate和Verfahren zu ihrer Herstellung。

    公开(公告)号：EP0497303A2

    公开(公告)日：1992-08-05

    申请号：EP92101449.4

    申请日：1992-01-29

    申请人： KYORIN PHARMACEUTICAL CO., LTD.

    发明人： Takano, Yasuo ,  Takadoi, Masanori ,  Hirayama, Takashi ,  Yamanishi, Atsuhiro

    IPC分类号： C07D401/04 ,  C07D417/04 ,  C07D401/14 ,  C07D211/40 ,  C07D211/54 ,  C07D211/46 ,  A61K31/445

    CPC分类号： C07D401/04 ,  C07D211/60 ,  C07D401/14 ,  C07D417/04

    摘要： Anti-dementia medicaments comprising a carbamic acid derivatives or their pharmaceutically acceptable acid addition salts having an anti-amnesic activity as an active ingredient are provided. The carbamic acid derivatives are represented by a general formula (1)

    wherein Ar denotes an aromatic heterocyclic ring which may have at least one substituent or its benzene-condensed ring, or phenyl group which may have at least one substituent, R¹ denotes hydrogen atom or lower alkyl group, R² denotes lower alkyl group which may be substituted with halogen atom, phenyl group which may have at least one substituent, naphthyl group, or five- or six-membered heterocyclic ring and its benzene-condensed ring, X and Y, which may be the same or different, denote sulfur atom or oxygen atom.

    摘要翻译： 提供了包含具有抗遗忘活性作为活性成分的氨基甲酸衍生物或其药学上可接受的酸加成盐的抗痴呆药物。 氨基甲酸衍生物由通式（1）表示，其中Ar表示可具有至少一个取代基的芳族杂环或其苯稠合的环，或可具有至少一个取代基的苯基， 1表示氢原子或低级烷基，R 2表示可以被卤素原子取代的低级烷基，可具有至少一个取代基的苯基，萘基或五元或六元杂环， 苯稠合环，X和Y可以相同或不同，表示硫原子或氧原子。

    Piperidine derivative, method for preparation thereof, and a pharmaceutical composition comprising the same
    47.
    发明公开
    Piperidine derivative, method for preparation thereof, and a pharmaceutical composition comprising the same 失效
    的哌啶衍生物，处理其制备以及含有该药物组合物。

    公开(公告)号：EP0399414A1

    公开(公告)日：1990-11-28

    申请号：EP90109534.9

    申请日：1990-05-19

    申请人： HOKURIKU PHARMACEUTICAL CO., LTD.

    发明人： Itoh, Yasuo ,  Kato, Hideo ,  Koshinaka, Eiichi ,  Ogawa, Nobuo ,  Nishino, Hiroyuki ,  Sakaguchi, Jun

    IPC分类号： C07D211/46 ,  C07D211/54 ,  A61K31/445

    CPC分类号： C07D211/54 ,  C07D211/46

    摘要： A piperidine derivative represented by the following general formula (I):
    wherein R₁ and R₂ are the same or different and each independently represents a hydrogen atom, a halogen atom, a lower alkyl group, or a lower alkoxy group; R₃ represents a hydrogen atom or a lower alkyl group; X represents an oxygen atom or a sulfur atom; Y represents an alkylene group having 1 to 7 carbon atoms which may be optionally substituted with a lower alkyl group, or Y represents an -A-O-B- group wherein A and B are the same or different and each independently represents an alkylene group having 1 to 3 carbon atoms which may be optionally substituted with a lower alkyl group is disclosed. Also disclosed are a pharmacologically acceptable salt of a compound of formula (I), an antihistaminic and antiallergic agent comprising a compound of formula (I), a pharmaceutical composition comprising a compound of formula (I), and a method for the treatment of an allergic disease by administering a compound of formula (I).

    摘要翻译： 由下述通式（I）表示的哌啶衍生物： worin R1和R2是相同或不同，并且各自unabhängigdarstellt氢原子，卤原子，低级烷基，或低级烷氧基; R 3表示氢原子或低级烷基; X darstellt到氧原子或硫原子; 具有可任选被低级烷基，或Y darstellt substituiertem到-AOB-组worin A和B是相同的或不同的，并且具有1至3的亚烷基基团的每个unabhängigdarstellt 1至7个碳原子的亚烷基基团Y的darstellt 这可能与低级烷基，任选地substituiertem碳原子是游离缺失盘。 所以游离缺失盘是式（I）中，在抗组胺和抗过敏剂，其包含式（I）的化合物的化合物，的药理学上可接受的盐的药物组合物包含式（I）的化合物，和用于的治疗的方法 通过施用式（I）的化合物的过敏性疾病。

    2-piperidino-1-alkanol derivatives as antiischemic agents
    48.
    发明公开
    2-piperidino-1-alkanol derivatives as antiischemic agents 失效
    2-哌啶子基-1-链烷醇 - 衍生物抗血清Wirkstoffe。

    公开(公告)号：EP0398578A2

    公开(公告)日：1990-11-22

    申请号：EP90304975.7

    申请日：1990-05-09

    申请人： PFIZER INC.

    发明人： Chenard, Bertrand Leo

    IPC分类号： C07D451/02 ,  A61K31/33 ,  A61K31/695 ,  C07D211/54 ,  C07D211/48 ,  C07D491/10 ,  C07D451/06 ,  C07D207/12 ,  C07F7/18

    CPC分类号： C07D451/02 ,  C07D211/48 ,  C07D211/52 ,  C07D211/54 ,  C07D211/70 ,  C07D451/04 ,  C07D451/06

    摘要： 2-(8-Azabicyclo[3.2.1]oct-8-yl)alkanols of the formula
    wherein Q is S or CH=CH; X is H, OH or another aromatic substituent; R is hydrogen, alkyl, alkenyl or alkynyl; Y and Y 1 are taken together and are arylmethylene or aralkylmethylene (or a corresponding epoxy derivative) or Y and Y 1 are taken separately and Y is hydrogen or OH, and Y 1 is aryl, aralkyl, arylthio, or aryloxy; and structurally related 2-(piperidino)alkanols; pharmaceutical compositions thereof; methods of treating CNS disorders therewith; and intermediates useful in the preparation of said compounds.

    摘要翻译： 其中Q是S或CH = CH的式（CHEM）的2-（8-氮杂双环[3.2.1]辛-8-基） X为H，OH或其它芳香取代基; R是氢，烷基，烯基或炔基; Y和Y 1相同，分别为芳基亚甲基或芳烷基亚甲基（或相应的环氧衍生物）或Y和Y 1，Y为氢或OH，Y 1为芳基，芳烷基，芳硫基， 或芳氧基; 和结构相关的2-（哌啶子基）链烷醇; 药物组合物; 治疗CNS疾病的方法; 和可用于制备所述化合物的中间体。