公开(公告)号：EP3309552B1

公开(公告)日：2024-01-17

申请号：EP16824767.4

申请日：2016-07-18

发明人： SONG, Ju-man ,  MIN, Seon-Gi ,  LEE, Seung-Soo ,  LEE, Do-min ,  PARK, Kyung-Hwa ,  HWANG, Moon-Chan ,  SHIN, Bong-Ki ,  JE, Jong-Tae

IPC分类号： C09B57/00 ,  C09B57/02 ,  C09B67/00 ,  G01N33/58 ,  A61K49/00

公开(公告)号：EP4263721A1

公开(公告)日：2023-10-25

申请号：EP21836601.1

申请日：2021-12-16

申请人： Illumina Cambridge Limited

发明人： CRESSINA, Elena ,  FRANCAIS, Antoine ,  LIU, Xiaohai

IPC分类号： C09B57/02 ,  C07H19/10 ,  C07H19/14 ,  C07H21/00 ,  C09K11/06 ,  C12Q1/686 ,  G01N21/64

公开(公告)号：EP3931190A1

公开(公告)日：2022-01-05

申请号：EP20707631.6

申请日：2020-02-28

申请人： Illumina Cambridge Limited

发明人： ROMANOV, Nikolai ,  MCCAULEY, Patrick ,  HYNES, Niall

IPC分类号： C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  C07H19/20 ,  C07H19/10 ,  C07H21/00 ,  C09B57/02

公开(公告)号：EP2695930B1

公开(公告)日：2019-09-11

申请号：EP12765873.0

申请日：2012-03-15

申请人： DIC Corporation

发明人： KUBOTA, Yusuke ,  IRISAWA, Masatomi ,  YANO, Toru ,  MATSUMOTO, Ken

IPC分类号： C07D311/06 ,  C07D265/34 ,  C07D265/36 ,  C07D265/38 ,  C09K19/32 ,  C09K19/34 ,  C09K19/54 ,  C09K19/60 ,  G02B5/30 ,  C08F220/30 ,  H01L51/52 ,  C09K19/04 ,  C09B57/06 ,  C09B57/02 ,  C09B69/10 ,  C08G59/00 ,  C08L63/00

公开(公告)号：EP1885875B1

公开(公告)日：2019-05-22

申请号：EP06771475.8

申请日：2006-05-31

申请人： PROMEGA CORPORATION

发明人： CALI, James J. ,  DAILY, William ,  HAWKINS, Erica ,  KLAUBERT, Dieter ,  LIU, Jianquan ,  MEISENHEIMER, Poncho ,  SCURRIA, Michael ,  SHULTZ, John, W. ,  UNCH, James ,  WOOD, Keith, V. ,  ZHOU, Wenhui ,  VALLEY, Michael, P.

IPC分类号： C07D277/68 ,  C07D311/16 ,  C07D417/04 ,  C07D417/14 ,  C07D493/10 ,  C07F9/6558 ,  C09B11/24 ,  C09B19/00 ,  C09B57/00 ,  C09B57/02 ,  C07D277/66 ,  C12Q1/66

公开(公告)号：EP2768906B1

公开(公告)日：2019-02-27

申请号：EP11776356.5

申请日：2011-10-18

申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

发明人： HELL, Stefan, W. ,  NIZAMOV, Shamil ,  DONNERT, Gerald ,  KOLMAKOV, Kirill ,  SCHILL, Heiko ,  KASTRUP, Lars ,  WURM, Christian, A. ,  BELOV, Vladimir, N. ,  WILDANGER, Johanna ,  WILLIG, Katrin

IPC分类号： G01N33/53 ,  G01N33/52 ,  G01N33/533 ,  G01N33/58 ,  C09B11/24 ,  C09B57/02 ,  C09B57/10

公开(公告)号：EP3314257A1

公开(公告)日：2018-05-02

申请号：EP16736957.8

申请日：2016-06-20

申请人： Life Technologies Corporation

发明人： MELQUIST, Penny ,  GEE, Kyle

IPC分类号： G01N33/50 ,  G01N33/58 ,  C07D311/16 ,  C07D311/54 ,  C07F9/655 ,  C09B57/02

CPC分类号： G01N33/5005 ,  C09B57/02 ,  G01N33/582

摘要： Described herein are compounds, methods, and kits for short- and long-term tracking of cell proliferation, differentiation, and/or function. The compounds disclosed herein are coumarin-based cell-tracking reagents that fluoresce in the blue portion of the UV/VIS spectrum and provide bright fluorescence intensity, uniform cell staining, good retention within cells and low toxicity toward cells.

公开(公告)号：EP2976083A4

公开(公告)日：2016-11-23

申请号：EP14767362

申请日：2014-03-20

申请人： UNIV INDIANA RES & TECH CORP

发明人： ZLOTNICK ADAM ,  LI LICHUN ,  VAN NIEUWENHZE MICHAEL S ,  TURNER WILLIAM W

IPC分类号： A61K31/505 ,  C09B11/08 ,  C09B11/24 ,  C09B23/02 ,  C09B57/00 ,  C09B57/02 ,  C09B57/10 ,  C12Q1/18 ,  G01N33/569

CPC分类号： G01N33/56983 ,  C09B11/08 ,  C09B11/24 ,  C09B23/02 ,  C09B57/00 ,  C09B57/02 ,  C09B57/10 ,  C12Q1/18 ,  G01N2333/02 ,  G01N2500/02 ,  G01N2500/04 ,  G01N2500/10

摘要： Heteroaryldihydropyrimidine (HAP)-based fluorescent stains (compounds), as well as uses of such stains as diagnostic reagents, viral-tracking agents, and/or tools for drug discovery are described. The present invention relates to heteroaryldihydropyrimidine (HAP)-based fluorescent stains (compounds), as well as uses of such stains as diagnostic reagents, viral-tracking agents, and/or tools for drug discovery.

公开(公告)号：EP2686684A1

公开(公告)日：2014-01-22

申请号：EP12709208.8

申请日：2012-02-28

申请人： Enzo Life Sciences, Inc.

发明人： COLEMAN, Jack ,  RABBANI, Elazar ,  STAVRIANOPOULOS, Jannis ,  PANDE, Praveen

IPC分类号： G01N33/58 ,  C12Q1/68 ,  C07D219/08 ,  C09B11/00 ,  C09B57/02 ,  G01N33/533

CPC分类号： C07H21/00 ,  C07D219/08 ,  C07D405/14 ,  C07D491/22 ,  C07H21/04 ,  C09B11/00 ,  C09B11/08 ,  C09B11/24 ,  C09B57/02 ,  C12Q1/68 ,  C12Q1/6818 ,  G01N33/533 ,  G01N33/582

摘要： Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group. Also provided are multisignal labeling reagents comprising (i) an oligomer of nucleotides or nucleotide analogs; (ii) a DNA supramolecular binding molecule noncovalently bound to the oligomer; and (iii) a first reactive group or a first partner of a first binding pair covalently bound to the oligomer. Additionally provided are methods of producing multisignal labeling reagents.

公开(公告)号：EP2223086B1

公开(公告)日：2013-03-20

申请号：EP08861025.8

申请日：2008-12-12

申请人： Biotium Inc.

发明人： MAO, Fei ,  LEUNG, Wai-Yee ,  CHEUNG, Ching-Ying ,  HOOVER, Hye, Eun

IPC分类号： G01N21/64 ,  C09B69/00 ,  C09B23/08 ,  C09B57/02

CPC分类号： G01N33/582 ,  C09B11/08 ,  C09B11/24 ,  C09B23/0066 ,  C09B23/06 ,  C09B23/083 ,  C09B23/086 ,  C09B57/001 ,  C09B57/02 ,  C09B69/00 ,  G01N21/6428 ,  G01N2021/6439

摘要： The present invention relates to fluorescent dyes. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. In one aspect, the invention provides a compound having a maximal fluorescence excitation wavelength, wherein the compound has a structure of Formula II: F—Y=Ψ  Formula II and wherein Z— is a counterion, Y is a bridge unit permitting electron delocalization between F and Ψ, and F is a moiety having the structure: The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.