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1.发明授权NOVEL PHOTOACTIVABLE FLUORESCENT DYES FOR OPTICAL MICROSCOPY AND IMAGING TECHNIQUES 有权新的光激活荧光探针用于光学显微镜和成像过程
公开(公告)号：EP2475722B1
公开(公告)日：2016-11-09
申请号：EP09778459.9
申请日：2009-09-10
发明人： HELL, Stefan , BELOV, Vladimir, N. , BOYARSKIY, Vadim, P. , WURM, Christian , JAKOBS, Stefan , GEISLER, Claudia
IPC分类号： C09B11/24
CPC分类号： C09B11/24
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2.发明公开NOVEL FLUORINATED RHODAMINES AS PHOTOSTABLE FLUORESCENT DYES FOR LABELLING AND IMAGING TECHNIQUES 有权新氟化丹明作为光稳定的荧光染料用于标记方法和成像
公开(公告)号：EP2445969A1
公开(公告)日：2012-05-02
申请号：EP09776857.6
申请日：2009-06-26
发明人： HELL, Stefan , BELOV, Vladimir, N. , MITRONOVA, Gyuzel , BOSSI, Mariano , MONERON, Gael , WURM, Christian , JAKOBS, Stefan , EGGELING, Christian , BIERWAGEN, Jakob , MEYER, Lars
CPC分类号： C07D311/82 , A61K49/0041 , A61K49/0058 , C07K1/13 , C09B11/24 , G01N33/582
摘要： The present invention relates to novel fluorinated 3,6-diaminoxanthene compounds derived from the basic structural formula (I) and to their uses as photostable fluorescent dyes, e.g. for immunostainings and spectroscopic and microscopic applications, in particular in conventional microscopy, stimulated emission depletion (STED) reversible saturable optically linear fluorescent transitions (RESOLFT) microscopy, and fluorescence correlation spectroscopy. The claimed compounds are also useful as molecular probes in various spectroscopic applications.
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3.发明公开FLUORESCENT DYES WITH PHOSPHORYLATED HYDROXYMETHYL GROUPS AND THEIR USE IN LIGHT MICROSCOPY AND IMAGING TECHNIQUES 审中-公开与磷酸化羟甲基和荧光染料它们在光学显微镜和成像过程
公开(公告)号：EP2768906A1
公开(公告)日：2014-08-27
申请号：EP11776356.5
申请日：2011-10-18
发明人： HELL, Stefan, W. , NIZAMOV, Shamil , DONNERT, Gerald , KOLMAKOV, Kirill , SCHILL, Heiko , KASTRUP, Lars , WURM, Christian, A. , BELOV, Vladimir, N. , BUECKERS, Johanna , WILLIG, Katrin
CPC分类号： G01N33/52 , C09B11/24 , C09B57/02 , C09B57/10 , G01N33/533 , G01N33/582 , G01N2458/00
摘要： The invention relates to novel fluorescent dyes with phosphorylated hydroxymethyl groups, a method for preparing the same as well as to their use in imaging techniques. The fluorescent dyes are coumarin, rhodamine or BODIPY dyes having of one of the following general formulae I-III: wherein W=OP(O)Y1Y2 or P(O)Y1Y2, where Y1 and Y2 independently denote any of the following residues: OH, O(−), ORa and ORb, NHRa and NHRb, NRaRb and NRcRd, ORa and NHRb, ORa and NRbRc, NHRa and NRbRc; and any salt thereof.
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4.发明授权NOVEL FLUORINATED RHODAMINES AS PHOTOSTABLE FLUORESCENT DYES FOR LABELLING AND IMAGING TECHNIQUES 有权新氟化丹明作为光稳定的荧光染料用于标记方法和成像
公开(公告)号：EP2445969B1
公开(公告)日：2014-08-27
申请号：EP09776857.6
申请日：2009-06-26
发明人： HELL, Stefan , BELOV, Vladimir, N. , MITRONOVA, Gyuzel , BOSSI, Mariano , MONERON, Gael , WURM, Christian , JAKOBS, Stefan , EGGELING, Christian , BIERWAGEN, Jakob , MEYER, Lars
CPC分类号： C07D311/82 , A61K49/0041 , A61K49/0058 , C07K1/13 , C09B11/24 , G01N33/582
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公开(公告)号：EP2768906B1
公开(公告)日：2019-02-27
申请号：EP11776356.5
申请日：2011-10-18
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6.发明公开NOVEL PHOTOACTIVABLE FLUORESCENT DYES FOR OPTICAL MICROSCOPY AND IMAGING TECHNIQUES 有权新的光激活荧光探针用于光学显微镜和成像过程
公开(公告)号：EP2475722A1
公开(公告)日：2012-07-18
申请号：EP09778459.9
申请日：2009-09-10
发明人： HELL, Stefan , BELOV, Vladimir, N. , BOYARSKIY, Vadim, P. , WURM, Christian , JAKOBS, Stefan , GEISLER, Claudia
CPC分类号： C09B11/24
摘要： The present invention relates to novel photoactivable rhodamine or carbopyronine derivatives of the following general formulae G1-G4 (I), G1: A1 = O, A2 = N, A3 = C; G2: A1 = S, A2 = N, A3 = C; G3: A1 = O, A2 = O, A3 = N; G4: A1 = S, A2 = O, A3 = N; comprising UV light absorbing chromophores which after photolysis by irradiation at 254-490 nm (preferably at 375-420 nm) generate fluorescent rhodamine or carbopyronine derivatives and small non-toxic fragments such as N
2 or N
2 O. The invention also relates to methods for preparing such compounds and to the use of these compounds for optical microscopy and imaging techniques.
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