公开(公告)号：EP2210085A1

公开(公告)日：2010-07-28

申请号：EP08842920.4

申请日：2008-10-25

申请人： Universal Biosensors, Pty. Ltd.

发明人： NEWMAN, Peter Michael ,  HODGES, Alastair M.

IPC分类号： G01N27/327 ,  G01N33/49 ,  G01N33/86 ,  A61B5/00 ,  G01N33/68 ,  C12Q1/56 ,  G01N33/82

CPC分类号： C12Q1/56 ,  G01N33/4905 ,  G01N33/86

摘要： The present invention is directed to a sensor with opposing electrodes and test strips using this sensor. The invention can be used to measure blood or plasma coagulation in assays like prothrombin time (PT) and thrombin potential, for example, in point-of-care monitoring of anticoagulants.

摘要翻译： 本发明涉及具有相对电极和使用该传感器的测试条的传感器。 例如，在凝血酶时间（PT）和凝血酶可能性的测定中，本发明可以用于测量血液或血浆凝固，例如在抗凝血剂的护理点监测中。

公开(公告)号：EP1533316A4

公开(公告)日：2009-11-11

申请号：EP03738537

申请日：2003-06-27

申请人： CHUGAI PHARMACEUTICAL CO LTD

发明人： ISHIGAI MASAKI ,  MURAO NAOAKI ,  SEKIGUCHI NOBUO ,  TAKAHASHI TADAKATSU

IPC分类号： C07C401/00 ,  C07F17/02 ,  G01N27/62 ,  G01N30/06 ,  G01N30/72 ,  G01N30/88 ,  G01N31/00 ,  G01N33/82

CPC分类号： C07C401/00 ,  C07F17/02 ,  G01N31/00 ,  G01N33/82

公开(公告)号：EP2008108A2

公开(公告)日：2008-12-31

申请号：EP07727168.2

申请日：2007-03-21

申请人： Metanomics GmbH

发明人： BETHAN, Bianca ,  BUSCH, Kristina ,  WIEMER, Jan ,  GIPMANS, Martijn ,  LEIBOLD, Edgar ,  SPRANGER, Jochen ,  BOBBERT, Thomas ,  PFEIFFER, Andreas Friedrich Hermann

IPC分类号： G01N33/62 ,  G01N33/66 ,  G01N33/68 ,  G01N33/70 ,  G01N33/92 ,  G01N33/82

CPC分类号： G01N33/92 ,  G01N33/6848 ,  G01N33/6893 ,  G01N2800/042 ,  G01N2800/52 ,  Y10T436/144444 ,  Y10T436/24

摘要： The present invention relates to a method for diagnosing a predisposition for diabetes comprising determining at least one metabolite in a test sample of a subject suspected to have a predisposition for diabetes and comparing said at least one metabolite to a reference, whereby a predisposition for diabetes is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. Further encompassed by the present invention are diagnostic means comprising at least one metabolite and the use of said at least one metabolite for the manufacture of diagnostic means for diagnosing a predisposition for diabetes. Finally, the present invention pertains to a method for identifying diabetes- related metabolites.

公开(公告)号：EP1257830B1

公开(公告)日：2007-04-18

申请号：EP01905961.7

申请日：2001-02-21

申请人： AXIS-SHIELD ASA

发明人： Sundrehagen, Erling ,  Orning, Lars

IPC分类号： G01N33/82 ,  G01N33/60

CPC分类号： G01N33/82

摘要： An assay method comprising the detection of holotranscobalamin II (holo-TCII) and folate in a cobalamin-containing sample from a subject.

公开(公告)号：EP1757944A1

公开(公告)日：2007-02-28

申请号：EP06111818.8

申请日：2001-10-12

申请人： ABBOTT LABORATORIES

发明人： Amdahl, Michael, J.

IPC分类号： G01N33/82 ,  A61K38/00

CPC分类号： G01N33/82 ,  G01N2800/52

摘要： A method is provided for determining the initial or starting dose of vitamin D compounds when used for the treatment of renal osteodystrophy or secondary hyperparathyroidism. The starting dose is based in part on the patient's baseline PTH. The invention also provides for the administration of an initial dose of a vitamin D compound wherein the dose is determined following the method of the invention.

摘要翻译： 提供了一种用于确定维生素D化合物在用于治疗肾性骨营养不良或继发性甲状旁腺功能亢进时的初始剂量或起始剂量的方法。 起始剂量部分基于患者的基线PTH。 本发明还提供给药初始剂量的维生素D化合物，其中剂量是按照本发明的方法测定的。

公开(公告)号：EP1257831B1

公开(公告)日：2006-05-03

申请号：EP01905964.1

申请日：2001-02-21

申请人： AXIS-SHIELD ASA

发明人： SUNDREHAGEN, Erling Axis-Shield ASA ,  ORNING, Lars Axis-Shield ASA

IPC分类号： G01N33/82

CPC分类号： G01N33/82 ,  G01N33/6893 ,  G01N2800/32

摘要： An assay method for the detection of cardiovascular disease, potential cardiovascular disease, megalobastic anemia, hyperhomocysteinemia or potential irreversible neurological disorders, in a human or non-human animal subject, said method comprising assessing the concentration of both holo-transcobolamin II (holo TCII) and folate in a cobalamin-containing sample from said subject and the optional assessment of total sample cobalamin. A kit for carrying out the assay method is also provided.

公开(公告)号：EP1443328A3

公开(公告)日：2004-10-20

申请号：EP04009702.4

申请日：1999-09-20

申请人： AXIS-SHIELD ASA

发明人： Sundrehagen, Erling ,  Örning, Lars

IPC分类号： G01N33/82 ,  C12Q1/00

CPC分类号： G01N33/82 ,  G01N33/54326

摘要： The invention provides an assay method for the determination of transcobalamin II (TCII) bound cobalamin in a body sample, comprising contacting a cell free sample of a body fluid with an immobilised or immobilizable specific binding ligand for TC II or cobalamin bound TCII (holo TC II), separating a ligand bound fraction from a non-ligand bound fraction and measuring the holo-TC II or TC-II bound cobalamin content therein.

摘要翻译： 本发明提供了测定体内样品中钴胺素II（TCII）结合钴胺素的测定方法，该方法包括使体液的无细胞样品与TC II或钴胺素结合TCII的固定化或可固定化特异性结合配体（holo TC II），将配体结合部分与非配体结合部分分离，并测量其中的holo-TC II或TC-II结合的钴胺素含量。

公开(公告)号：EP1443328A2

公开(公告)日：2004-08-04

申请号：EP04009702.4

申请日：1999-09-20

申请人： AXIS-SHIELD ASA

发明人： Sundrehagen, Erling ,  Örning, Lars

IPC分类号： G01N33/82 ,  C12Q1/00

CPC分类号： G01N33/82 ,  G01N33/54326

摘要： The invention provides an assay method for the determination of transcobalamin II (TCII) bound cobalamin in a body sample, comprising contacting a cell free sample of a body fluid with an immobilised or immobilizable specific binding ligand for TC II or cobalamin bound TCII (holo TC II), separating a ligand bound fraction from a non-ligand bound fraction and measuring the holo-TC II or TC-II bound cobalamin content therein.

摘要翻译： 本发明提供了一种用于测定身体样品中的转钴胺素（TCII）结合的钴胺素的测定方法，包括使体液的无细胞样品与固定化或可固定的特异性结合配体用于TC II或钴胺素结合的TCII（holo TC II），从非配体结合部分分离配体结合部分并测量其中的全-TC II或TC-II结合的钴胺素含量。

公开(公告)号：EP1412756A2

公开(公告)日：2004-04-28

申请号：EP02733970.4

申请日：2002-04-05

申请人： Johnson & Johnson Consumer Companies, Inc.

发明人： SKOVER, Gregory

IPC分类号： G01N33/68 ,  G01N33/74 ,  G01N33/82

摘要： The present invention relates to a method of examining or diagnosing the skin health in a subject, the method including the steps of: accessing a sample of interstitial fluid from the skin of the subject; and measuring the amount of a skin analyte in the sample. The present invention also relates to a method of treating the skin of a subject and method of distributing a skin care product to a subject.

公开(公告)号：EP1360507A2

公开(公告)日：2003-11-12

申请号：EP01992054.5

申请日：2001-12-03

申请人： Quest Diagnostics Inc

发明人： GARRITY, Martha ,  TRAN, Jacqueline

IPC分类号： G01N33/82

CPC分类号： G01N33/82

摘要： The present invention features a kit and a method of using the kit for determining a concentration of a vitamin D component. The kit comprises a releasing composition and a detecting composition. The releasing composition comprises an aqueous base component. In one embodiment, the releasing composition is substantially free from an organic solvent.