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公开(公告)号：EP1086950A4
公开(公告)日：2002-11-06
申请号：EP99921245
申请日：1999-05-25
发明人： MATSUOKA HIROHARU , KATO NOBUAKI , TAKAHASHI TADAKATSU , MARUYAMA NORIAKI , ISHIZAWA TAKENORI , SUZUKI YUKIO
IPC分类号： A61P29/00 , A61P43/00 , C07D401/04 , C07D401/06 , C07D403/04 , C07D405/04 , C07D405/06 , C07D413/04 , C07D417/04 , C07D417/06 , C07D471/04 , C07D487/04 , A61K31/40 , A61K31/41 , A61K31/42 , A61K31/435 , A61K31/44 , A61K31/495
CPC分类号： C07D401/04 , C07D401/06 , C07D403/04 , C07D405/04 , C07D405/06 , C07D413/04 , C07D417/04 , C07D417/06 , C07D471/04 , C07D487/04
摘要： Indole derivatives and mono- or diazaindole derivatives represented by general formula (1), pharmaceutically acceptable acid-addition salts or base-addition salts thereof or hydrates of the same which have a COX-2 inhibitory activity and are useful as drugs such as anti-inflammatory agents, wherein Het represents an optionally substituted heterocycle; A1 and A2 independently represent each -CH=, etc.; A3 represents -CH2-, etc.; R1 represents 4-fluorophenyl, etc.; R2 represents alkyl; and n is 0, 1 or 2, provided that when A1 and A2 are both -CH=, then A3 is -CH2- or -SO2-.
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公开(公告)号：EP1149843A4
公开(公告)日：2012-06-06
申请号：EP00901956
申请日：2000-01-28
发明人： MATSUOKA HIROHARU , SATO TSUTOMU , TAKAHASHI TADAKATSU , KIM DONG ICK , JUNG KYUNG YUN , PARK CHAN HEE
IPC分类号： A61K38/00 , A61P1/00 , A61P5/00 , C07C215/52 , C07C229/06 , C07C229/12 , C07C229/36 , C07C229/48 , C07C237/08 , C07C237/10 , C07C237/20 , C07C271/18 , C07C271/20 , C07C271/22 , C07D295/185 , C07D295/26 , C07K5/06 , C07K5/08 , C07K5/087 , C07K5/097 , A61K38/06
CPC分类号： C07D295/185 , A61K38/00 , C07B2200/07 , C07C215/52 , C07C229/06 , C07C229/12 , C07C229/36 , C07C229/48 , C07C237/08 , C07C237/10 , C07C237/20 , C07C271/18 , C07C271/20 , C07C271/22 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D295/26 , C07K5/06191 , C07K5/0812 , C07K5/0821 , C07K5/0827
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