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公开(公告)号：EP0820463A4
公开(公告)日：2001-08-08
申请号：EP96912727
申请日：1996-04-12
申请人： CEPHALON INC
IPC分类号： C12N15/09 , C07K1/18 , C07K1/20 , C07K1/36 , C07K14/65 , C12N15/18 , C12P21/00 , C12R1/84 , G01N30/02 , C07K1/16
CPC分类号： C07K14/65 , G01N30/02 , B01D15/422
摘要： Disclosed is a process for obtaining purified, monomeric, intact, correctly-folded insulin-like growth factor-I (also known as somatomedin-C). The process includes the addition of an IGF-I unfolding/refolding step and the substitution of a reverse phase chromatography step for a gel filtration chromatography step in order to increase the final yield. The process also includes the following steps in order: first cation exchange, unfolding/refolding, hydrophobic interaction chromatography, second cation exchange, and reverse phase chromatography.
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52.发明公开THIOMETHYLENE GROUP-CONTAINING ALDEHYDE CYSTEINE AND SERINE PROTEASE INHIBITORS 失效醛和SERIN半胱氨酸蛋白酶抑制剂含硫代亚甲基GROUP
公开(公告)号：EP0958354A4
公开(公告)日：2001-06-13
申请号：EP97939665
申请日：1997-08-28
申请人： CEPHALON INC
发明人： CHATTERJEE SANKAR
IPC分类号： C12N9/99 , A61K31/16 , A61P43/00 , C07C317/44 , C07C323/60
CPC分类号： C07C323/60 , C07C317/44
摘要： The present invention is directed to novel thiomethylene group-containing aldehyde inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.
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53.发明公开ALPHA-KETOAMIDE MULTICATALYTIC PROTEASE INHIBITORS 有权ALPHA-KETAAMIDHALTIGE MULTIKATALYTISCHE PROTEASE INHIBITOREN
公开(公告)号：EP1027056A4
公开(公告)日：2001-03-21
申请号：EP98953274
申请日：1998-10-07
申请人： CEPHALON INC
发明人： CHATTERJEE SANKAR , MALLAMO JOHN P
IPC分类号： C12N9/99 , A61K38/00 , A61P3/10 , A61P35/00 , A61P43/00 , C07D209/48 , C07D403/12 , C07K5/06 , A61K31/55 , A61K31/40 , A61K31/495 , A61K31/50 , C07D401/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D415/00
CPC分类号： C07D209/48 , C07D403/12
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公开(公告)号：EP0966962B1
公开(公告)日：2001-02-21
申请号：EP99202603.9
申请日：1995-10-04
申请人： Cephalon, Inc.
发明人： Grebow, Peter E. , Stong, David , Corvari, Vincent
IPC分类号： A61K31/165 , A61K9/16 , A61K9/14
CPC分类号： A61K9/16 , A61K9/14 , A61K31/165
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55.发明授权FUSED PYRROLO(2,3-C)CARBAZOLE-6-ONES WHICH POTENTIATE ACTIVITY OF GAMMA INTERFERON 失效简明吡咯并（2,3-C）咔唑-6-酮γ-干扰素增强的活性
公开(公告)号：EP0885229B1
公开(公告)日：2000-08-02
申请号：EP97914792.3
申请日：1997-02-20
申请人： CEPHALON, INC.
IPC分类号： C07D491/14 , C07D495/14 , C07D487/14 , C07D487/04 , A61K31/40
CPC分类号： C07D487/04 , C07D487/14 , C07D493/14 , C07D495/14
摘要： Disclosed in this patent document are synthetic, biologically active molecules referred to as fused pyrrolo(2,3-c)carbazole-6-ones. These molecules are represented by general formulae (I) and (II). Methods for making and using the fused pyrrolo(2,3-c)carbazole-6-ones are also disclosed.
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56.发明公开USE OF K-252A DERIVATIVE FOR THE TREATMENT OF PERIPHERAL OR CENTRAL NERVE DISORDERS, AND CYTOKINE OVERPRODUCTION 失效K-252A衍生物的用于外周神经疾病与过量细胞素的中枢神经治疗或用途
公开(公告)号：EP0912184A1
公开(公告)日：1999-05-06
申请号：EP97930203.0
申请日：1997-06-24
申请人： CEPHALON, INC.
发明人： ENGBER, Thomas, M. , HAUN, Forrest, A. , SAPORITO, Michael, S. , AIMONE, Lisa, D. , MILLER, Matthew, S. , KNIGHT, Ernest, Jr.
CPC分类号： A61K31/554 , A61K31/55 , A61K31/553
摘要： Disclosed herein are therapeutic methodologies utilizing a ring substituted derivative of the indolocarbazole K252a, the derivative represented by the formula (A). The compound is useful for treating peripheral neuropathies, central neuronal degeneration and cytokine overproduction. Typical diseases related to the above are peripheral neuropathy, Alzheimer's disease, Parkinson's disease and autoimmune and allergic conditions.
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公开(公告)号：EP0871612A1
公开(公告)日：1998-10-21
申请号：EP96943735.0
申请日：1996-12-11
申请人： CEPHALON, INC.
IPC分类号： C07D209
CPC分类号： C07D209/70
摘要： Disclosed are biologically active, non-indole-containing compounds referred to as fused isoindolones, which are represented by general formula (I). The fused indolones can be obtained by complete chemical synthesis. Methods for making and using the fused isoindolones are disclosed.
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公开(公告)号：EP0820463A1
公开(公告)日：1998-01-28
申请号：EP96912727.0
申请日：1996-04-12
申请人： CEPHALON, INC.
CPC分类号： C07K14/65 , G01N30/02 , B01D15/422
摘要： Disclosed is a process for obtaining purified, monomeric, intact, correctly-folded insulin-like growth factor-I (also known as somatomedin-C). The process includes the addition of an IGF-I unfolding/refolding step and the substitution of a reverse phase chromatography step for a gel filtration chromatography step in order to increase the final yield. The process also includes the following steps in order: first cation exchange, unfolding/refolding, hydrophobic interaction chromatography, second cation exchange, and reverse phase chromatography.
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公开(公告)号：EP0786996A1
公开(公告)日：1997-08-06
申请号：EP95940706.0
申请日：1995-11-03
申请人： CEPHALON, INC.
IPC分类号： C12N9 , A61K31 , A61P43 , C07C59 , C07D235 , C07D249 , C07D311 , C07D405 , C07D471 , C07D521
CPC分类号： C07D405/12 , C07C59/84 , C07D235/22 , C07D249/18 , C07D311/82 , C07D471/04
摘要： The present invention is directed to irreversible inhibitors of serine and cysteine proteases which most preferably contain a 1-oxytriazole or 1-oxyimidazole functionality. Methods for the use of the protease inhibitors are also described.
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公开(公告)号：EP0785938A1
公开(公告)日：1997-07-30
申请号：EP95938713.0
申请日：1995-10-03
申请人： CEPHALON, INC.
CPC分类号： C07D487/04 , C07D491/14 , C07D495/14
摘要： Disclosed herein are compounds referred to as 'fused pyrrolocarbazoles' which possess a variety of functional pharmacological activities including effect on the function and/or survival of trophic factor responsive cells; inhibition of enzymatic activity; inhibition of inflammation-associated responses; inhibition of cell growth associated with hyperproliferative states; and inhibition of developmentally programmed mononeuron death. The disclosed compounds are represented by general formula (G). Methodologies for the synthetic production of fused pyrrolocabazoles are also disclosed, as well as exemplary uses of the compounds.
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