-
51.发明公开
公开(公告)号：EP2373690A2
公开(公告)日：2011-10-12
申请号：EP09799402.4
申请日：2009-12-08
申请人： Compugen Ltd.
发明人： LEVINE, Zurit , ROSENBERG, Avi Yeshah , ROTMAN, Galit , TOPORIK, Amir , KINAR, Yaron , NEMZAR, Sergey , COHEN-DAYAG, Anat , WALACH, Shira , SAMEACH-GREENWALD, Shirley , DASSA, Liat , BEIMAN, Merav , MONTIA, Eve , LEVY, Ofer , NOVIK, Amit
IPC分类号： C07K16/28 , C07K14/705
CPC分类号： C07K16/28 , A61K38/00 , A61K39/39558 , A61K2039/505 , C07K14/47 , C07K16/30 , C07K16/3015 , C07K16/3038 , C07K16/3053 , C07K16/3061 , C07K16/3069 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12Q1/6886 , C12Q2600/136 , G01N33/57484 , G01N33/577 , G01N2333/47
摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against FAM26F antigens, which are differentially expressed in cancer, and diagnostic and therapeutic usages. This invention further relates to extracellular domains of FAM26F, proteins and variants, and therapeutic usages thereof.
摘要翻译： 本发明涉及用于产生免疫和非免疫的治疗剂和疾病诊断的新靶标。 更具体地，本发明提供了针对FAM26F抗原的治疗性抗体，其在癌症中差异表达，以及诊断和治疗用途。 本发明还涉及FAM26F的细胞外结构域，蛋白质和变体及其治疗用途。
-
52.发明公开POLYPEPTIDES AND POLYNUCLEOTIDES, AND USES THEREOF AS A DRUG TARGET FOR PRODUCING DRUGS AND BIOLOGICS 有权多肽和多核苷酸及其作为目标分子用于生产药物和生物制剂
公开(公告)号：EP2190469A4
公开(公告)日：2011-02-16
申请号：EP08829443
申请日：2008-09-03
申请人： COMPUGEN LTD
发明人： LEVINE ZURIT , ROSENBERG AVI , ROTMAN GALIT , NOVIK AMIT , TOPORIK AMIR , KINAR YARON , NEMZER SERGEY , KOIFMAN CYNTHIA , BEIMAN MERAV , DASSA LIAT , WALACH SHIRA , MONTIA EVE , SAMEACH-GREENWALD SHIRLEY , PERGAM TANIA , MILO DALIT , COHEN-DAYAG ANAT , LEVY OFER , BUBIS MARINA
IPC分类号： A61K39/00
CPC分类号： C07K16/30 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K39/0005 , A61K39/0008 , A61K39/39 , A61K39/395 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/545 , A61N5/10 , C07K14/00 , C07K14/47 , C07K14/4702 , C07K14/705 , C07K14/70503 , C07K14/82 , C07K16/28 , C07K2317/21 , C07K2317/76 , C07K2319/00 , C07K2319/30 , C07K2319/60 , C07K2319/70 , G01N33/564 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N33/57484 , G01N33/57492 , G01N2500/04
摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against C1ORF32 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages. The use of these antibodies for modulating B7 costimulation is also provided. This invention further relates to the discovery of extracellular domains of C1ORF32 and its variants awhich are suitable targets for cancer therapy, and drug development.
-
53.发明公开Novel nucleotide and amino acid sequences, and methods of use thereof for diagnosis 审中-公开新型核苷酸和氨基酸序列和用于诊断它们的使用的新方法
公开(公告)号：EP2216339A1
公开(公告)日：2010-08-11
申请号：EP10150046.0
申请日：2007-01-16
申请人： Compugen Ltd.
发明人： Sella-Tavor, Osnat , Pollock, Sarah , Bazak, Lily , Tsypkin, Elena , Sztybel, Dan , Sameah-Greenwald, Shirley
IPC分类号： C07H21/02
CPC分类号： G01N33/57423
摘要： The present invention relates to diagnostic markers comprising novel splice variants of known proteins and polynucleotides encoding same, useful in the qualitative and/or quantitative detection of various diseases and/or pathological conditions in a subject, and to the use of known proteins and polynucleotides encoding same for diagnosis. Particularly, the invention relates to the diagnosis of a disease in a sample of body fluid or secretion obtained from the subject, and to the diagnosis of cancer.
摘要翻译： 本发明涉及诊断用标记物，其包括已知的蛋白和多核苷酸编码相同，在各种疾病和/或病理状况的受试者的定性和/或定量检测有用的新的剪接变体，并使用公知的蛋白质和多核苷酸编码的 同样的诊断。 特别地，本发明涉及的疾病的体液或分泌物获自受试者的样品中的诊断，和癌症的诊断。
-
54.发明公开NOVEL NUCLEOTIDE AND AMINO ACID SEQUENCES, AND METHODS OF USE THEREOF FOR DIAGNOSIS 审中-公开NEW核苷酸和氨基酸序列，并且应用在诊断方法
公开(公告)号：EP1973945A2
公开(公告)日：2008-10-01
申请号：EP07700747.4
申请日：2007-01-16
申请人： Compugen Ltd.
发明人： SELLA-TAVOR, Osnat , POLLOCK, Sarah , BAZAK, Lily , TSYPKIN, Elena , SZTYBEL, Dan , SAMEAH-GREENWALD, Shirley
IPC分类号： C07K14/82
CPC分类号： G01N33/57423
摘要： The present invention relates to diagnostic markers comprising novel splice variants of known proteins and polynucleotides encoding same, useful in the qualitative and/or quantitative detection of various diseases and/or pathological conditions in a subject, and to the use of known proteins and polynucleotides encoding same for diagnosis. Particularly, the invention relates to the daignosis of a disease in a sample of body fluid or secretion obtained from the subject, and to the diagnosis of cancer.
-
公开(公告)号：EP1721257A2
公开(公告)日：2006-11-15
申请号：EP05780004.7
申请日：2005-01-27
申请人： Compugen Ltd.
发明人： COJOCARU, Gad, S. , POLLOCK, Sarah , LEVINE, Zurit , DIBER, Alexander , KOL, Guy , TOPORIK, Amir , SOREK, Rotem , DAHARY, Dvir , AYALON-SOFFER, Michal , AKIVA, Pinchas , NOVIK, Amit , COHEN, Yossi , SELLA-TAVOR, Osnat , WALACH, Shira , SAMEAH-GREENWALD, Shirley , SHEMESH, Ronen , SHKLAR, Maxim
IPC分类号： G06F15/16
CPC分类号： C12Q1/6886 , C12Q2600/112
摘要： Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.
-
公开(公告)号：EP1373903A2
公开(公告)日：2004-01-02
申请号：EP01978793.6
申请日：2001-10-11
申请人： Compugen Ltd.
发明人： SMILANSKY, Zeev
IPC分类号： G01N33/68
CPC分类号： G01N33/6848 , G01N33/6803 , G01N33/6818 , G01N33/6842
摘要： A method is described for determining the mass of a mass altering moiety, and for identifying a cleavage altering sequence, wherein the mass altering moiety or a cleavage altering sequence is present in an assayed peptide and is absent from a corresponding database peptide, or is present in a database peptide and is absent from an assayed peptide.
-
公开(公告)号：EP1230359A1
公开(公告)日：2002-08-14
申请号：EP00973208.2
申请日：2000-11-10
申请人： Compugen Ltd.
CPC分类号： C07K14/475 , A61K38/00
摘要： The present invention concerns several splice variants of a chordin line homologs (CLH) and depicts their nucleic acid and amino acid sequences, vectors and host cells containing said nucleic acid sequences and antibodies reactive with the amino acid sequences. The invention also concerns pharmaceutical compositions for the treatment of a plurality of diseases, comprising nucleic acid sequences, amino acid sequences, expression vectors, antibodies. The invention also concerns methods for detecting the above nucleic acid, amino acid sequences or antibody in a biological sample.
-
公开(公告)号：EP1200584A1
公开(公告)日：2002-05-02
申请号：EP00944205.4
申请日：2000-07-19
申请人： Compugen Ltd.
IPC分类号： C12N15/12 , C07K14/705 , C07K16/28 , A61K38/17 , A61K39/395 , A61K48/00 , C12Q1/68 , G01N33/50
CPC分类号： C07K14/70578 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2121/00
摘要： The present invention concerns six novel variants of alternative splicing of the CD40 receptor.
-
公开(公告)号：EP3617232A1
公开(公告)日：2020-03-04
申请号：EP19199752.7
申请日：2017-08-17
申请人： Compugen Ltd.
发明人： WHITE, Mark , KUMAR, Sandeep , CHAN, Christopher , LIANG, Spencer , STAPLETON, Lance , DRAKE, Andrew W. , GOZLAN, Yosi , VAKNIN, Ilan , SAMEAH-GREENWALD, Shirley , DASSA, Liat , TIRAN, Zohar , COJOCARU, Gad S. , KOTTURI, Maya , CHENG, Hsin-Yuan , HANSEN, Kyle , GILADI, David Nisim , SAFYON, Einav , OPHIR, Eran , PRESTA, Leonard , THEOLIS, Richard , DESAI, Radhika , WALL, Patrick
IPC分类号： C07K16/28 , A61K39/395 , A61K39/00
摘要： Anti-PVRIG and anti-TIGIT antibodies are provided.
-
公开(公告)号：EP2726503B1
公开(公告)日：2019-09-04
申请号：EP12804342.9
申请日：2012-07-01
申请人： Compugen Ltd.
IPC分类号： C07K14/705 , C07K16/46 , A61K38/17 , A61P37/06
-
-
-
-
-
-
-
-
-
搜索结果
103 条记录 (耗时 0.07 秒)
