公开(公告)号：EP2065422A1

公开(公告)日：2009-06-03

申请号：EP07806680.0

申请日：2007-09-04

申请人： Keio University

发明人： EBATA, Hiroki ,  MATSUMURA, Shuichi

IPC分类号： C08G63/06 ,  C08G63/82 ,  C12P7/62

CPC分类号： C08G63/06 ,  C08G63/82 ,  C08L67/06 ,  C12P7/625 ,  C08K3/011

摘要： A process is disclosed wherein ricinoleic acid from petroleum alternative vegetable castor oil that has a hydroxyl group at the 12-position or a derivative thereof (an ester or a hydrogenated compound thereof) is polymerized in the presence of a synthetic zeolite and an immobilized lipase at around normal temperature without using any harmful polymerization catalysts or organic solvents which can cause environmental pollution whereby a polyester useful in the industry that has a weight average molecular weight of 20,000 or more is obtained. This high-molecular weight polyester is crosslinked to give a crosslinked elastomers that is comparable to synthetic rubbers.

摘要翻译： 公开了一种方法，其中将在12位具有羟基的石油替代植物蓖麻油中的蓖麻油酸或其衍生物（酯或其氢化化合物）在合成沸石和固定化脂肪酶的存在下聚合 而无需使用任何可导致环境污染的有害聚合催化剂或有机溶剂，从而获得重均分子量为20,000或更高的工业中有用的聚酯。 该高分子量聚酯交联得到与合成橡胶相当的交联弹性体。

公开(公告)号：EP2025354A1

公开(公告)日：2009-02-18

申请号：EP07743205.2

申请日：2007-05-11

申请人： Keio University ,  Meiji Seika Kaisha Ltd.

发明人： IZUMI, Yotaro ,  KAWAMURA, Masafumi ,  KOBAYASHI, Koichi ,  ENDO, Takeshi ,  NAGAI, Atsushi ,  SHICHINOHE, Makoto

IPC分类号： A61L31/00 ,  A61K31/785 ,  A61P7/04 ,  A61P41/00

CPC分类号： A61K31/785 ,  A61L31/06 ,  C08L77/04

摘要： There is disclosed an organ-adhesion preventing agent comprising a chemically-crosslinked γ-polyglutamic acid as an effective ingredient, as well as a process for preventing organ from adhesion comprising a step of bringing the adhesion-preventing agent into contact with or depositing the same onto the surface of a local organ and optionally the neighborhood thereof to be prevented from the post-operative adhesion. According to the present invention, there is provided an adhesion-preventing agent which is capable of effectively preventing the surfaces of organs from adhesion, and which can be absorbed in the body with high safety and be produced with ease and has high practical usefulness, as well as a process for preventing organ from adhesion by using the adhesion-preventing agent.

摘要翻译： 公开了一种包含化学交联的3-聚谷氨酸作为有效成分的器官粘附防止剂，以及防止器官粘连的方法，包括使粘附防止剂与其接触或沉积的步骤 到局部器官的表面上，并且可选地，其附近被防止术后粘连。 根据本发明，提供了一种能够有效地防止器官表面粘附的粘合防止剂，其能够以高安全性被吸收在身体中并且易于制造并且具有高实用性，如 以及通过使用防粘连剂防止器官粘连的方法。

公开(公告)号：EP2003447A2

公开(公告)日：2008-12-17

申请号：EP07740305.3

申请日：2007-03-29

申请人： Horiba, Ltd. ,  Keio University ,  Matsumoto, Koichi

发明人： EINAGA, Yasuaki ,  IVANDINI ANGGRANINGRUM, Tribidasari ,  CHIKU, Masanobu ,  YAMANUKI, Mikito

IPC分类号： G01N27/416 ,  G01N27/30

CPC分类号： G01N33/5438 ,  G01N27/48 ,  G01N33/6827 ,  G01N2333/76 ,  G01N2800/347

摘要： The present claimed invention is to provide a method for measuring a protein that enables to detect the protein with high accuracy and high sensitivity through an electrochemical method at a high speed with a simple operation using a simple device. With the method, a working electrode 5 and a counter electrode 4 are made to contact with a sample solution 1 containing the protein as being an object to be measured, and a voltage is impressed between the working electrode 5 and the counter electrode 4 so that a current value at the voltage can be measured and the protein can be electrochemically analyzed.

摘要翻译： 本发明提供一种蛋白质的测定方法，其能够通过使用简单的装置的简单操作，通过高速电化学方法以高精度和高灵敏度检测蛋白质。 利用该方法，使工作电极5和对电极4与包含蛋白质的样品溶液1作为被测量物体接触，并且在工作电极5和对电极4之间施加电压，使得 可以测量电压下的电流值，并可以电化学分析蛋白质。

公开(公告)号：EP2003198A2

公开(公告)日：2008-12-17

申请号：EP07737966.7

申请日：2007-03-07

申请人： Keio University

发明人： SATO, Toshinori ,  MATSUBARA, Teruhiko

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61P31/16 ,  C07K7/06 ,  C07K7/08 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10

CPC分类号： C07K14/005 ,  A61K38/00 ,  C07K5/06026 ,  C07K5/0806 ,  C07K5/1008 ,  C07K5/1024 ,  C12N2760/16122

摘要： To provide a peptide having high affinity for hemagglutinin and a peptide having high inhibitory activity against influenza virus infection, as well as a pharmaceutical composition containing such peptides, the polypeptides having any one of SEQ ID NOs: 2 to 7, 9 to 10, and 12 to 18 are obtained by introducing mutation into a peptide having the sequence of ARLSPTMVHPNGAQP (peptide A-1: SEQ ID NO: 1) and screening for peptides having higher affinity for hemagglutinin. Further, the inhibitory activity of the peptide of SEQ ID NO: 3 against influenza virus infection can be enhanced by truncating the C-terminus of SEQ ID NO: 3 with leaving ARLPR or ARLP. In addition, an influenza virus-infection inhibitor and an influenza preventive/therapeutic agent can be prepared by formulating these influenza virus receptor-binding peptides.

摘要翻译： 为了提供对血凝素的高亲和力和具有针对甲型流感病毒感染抑制活性高的肽的肽，以及含有寻求肽的药物组合物，具有该多肽为SEQ ID NO中的任一个：2月9日至10日至7，和 12至18中引入突变而具有ARLSPTMVHPNGAQP的序列的肽获得（：SEQ ID NO：肽A-1 1）和筛选具有血凝素较高的亲和力的肽。 此外，SEQ ID NO：2的肽的抑制活性：与离开ARLPR或ARLP 3：针对流感病毒感染3可以通过截短SEQ ID NO：2的C端来增强。 除了流感病毒感染抑制剂和流感的预防/治疗剂可通过配制论文流感病毒的受体结合的肽来制备。

公开(公告)号：EP1990060A1

公开(公告)日：2008-11-12

申请号：EP07707458.1

申请日：2007-01-26

申请人： Keio University ,  CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人： ISHIDA, Susumuc/o School of Medicine

IPC分类号： A61K45/00 ,  A61K39/395 ,  A61P27/02

CPC分类号： C07K16/2866 ,  A61K2039/505

摘要： The present inventors focused on the fact that inflammation at the subretinal macular area enhances choroidal neovascularization, and developed pharmaceutical agents that suppress initiation or advancement of neovascularization by angiogenic factors such as VEGF. More specifically, the present inventors revealed that administering anti-IL-6 receptor monoclonal antibodies to mice treated with laser photocoagulation inhibits the development of choroidal neovascularization.

摘要翻译： 本发明人着眼于在黄斑部视网膜下的炎症factthat增强脉络膜新生血管，并制定药剂通过血管生成因子抑制做启动或新生血管形成的进步：如VEGF。 更具体地，本发明人揭示并管理抗IL-6受体的单克隆抗体，以与激光光凝处理的小鼠抑制脉络膜新生血管形成的发展。

公开(公告)号：EP1940168A1

公开(公告)日：2008-07-02

申请号：EP06810780.4

申请日：2006-09-28

申请人： KDDI Corporation ,  Keio University

发明人： KIMURA, Hiroaki ,  IZAWA, Shingo ,  ISHIDA, Takaaki ,  KATAOKA, Kotaro

IPC分类号： H04N7/173 ,  H04B7/26 ,  H04H1/00 ,  H04Q7/38

CPC分类号： H04H60/82 ,  H04H20/24 ,  H04H20/71 ,  H04H20/95 ,  H04N7/17318 ,  H04N21/4516 ,  H04N21/4524 ,  H04N21/4532 ,  H04N21/454 ,  H04N21/4542 ,  H04N21/6125 ,  H04N21/6405 ,  H04W4/06

摘要： A content transmitting apparatus includes a content transmitting unit (111) that IP packetizes content to be transmitted through a communication network (101), and an encapsulating unit (112) that encapsulates the content IP packetized by the content transmitting unit (111) to generate a transmission packet to be transmitted through a broadcast network (102) for digital broadcast media. The content transmitting unit (111) and the encapsulating unit (112) transmit plural content items by IP multicast. The content transmitting unit (111) adds, to a header of the content to be IP packetized, information concerning a condition of a receiving side node of the content.

摘要翻译： 内容发送装置包括：IP分组通过通信网络（101）发送的内容的内容发送单元（111），以及封装单元（112），封装由内容发送单元（111）分组化的内容IP，生成 要通过用于数字广播媒体的广播网络（102）发送的传输分组。 内容发送单元（111）和封装单元（112）通过IP多播发送多个内容。 内容发送单元（111）将要分配IP的内容的报头与内容的接收侧节点的条件相关联。

公开(公告)号：EP1879022A1

公开(公告)日：2008-01-16

申请号：EP06731614.1

申请日：2006-04-11

申请人： Keio University

发明人： OGAWA, Kuniyasu c/o Keio University ,  HAISHI, Tomoyuki ,  ITO, Kohei

IPC分类号： G01N24/08 ,  G01R33/32 ,  G01R33/341 ,  G01R33/38

CPC分类号： G01R33/44 ,  G01N24/08 ,  G01R33/341 ,  G01R33/3415 ,  G01R33/3806 ,  G01R33/3808 ,  G01R33/48 ,  G01R33/56341

摘要： An instrument locally measuring mobility of a protic solvent in a sample 115 based on the gradient magnetic field NMR method has a sample stage 116 on which the sample 115 is placed, a magnet 113 applying a static magnetic field to the sample 115, a G coil 151 and a G coil 153 applying a gradient magnetic field to the sample 115, a small-sized RF coil 114 smaller in size than the G coil 151 applying an oscillating magnetic field for excitation and acquiring an NMR signal corresponded to the oscillating magnetic field for excitation and the gradient magnetic field; a pulse control unit 108 alloing application of the gradient magnetic field and oscillating magnetic field for excitation to be executed according to a predetermined pulse sequence; and an operation unit 130 calculating the mobility at the specific position of the G coil 151, based on information of the NMR signals acquired corresponding to different gradient magnetic fields.

摘要翻译： 仪器测量局部质子溶剂的移动性基于梯度磁场NMR方法的样品115中具有其上样品115被置于样品台116，磁体113施加静态磁场以样品115，G的线圈 151和A G线圈153施加梯度磁场，以在样品115中，在尺寸除G线圈151施加用于激励振荡磁场和NMR信号的获取的小型射频线圈114更小的对应于振荡磁场为 激发和梯度磁场; 梯度磁场和振动磁场激发待执行的gemäß到预定的脉冲序列的脉冲控制单元108 Alloing应用; 并在操作单元130计算的迁移率在G线圈151的具体位置，基于对应于不同的梯度磁场所获取的NMR信号的信息。

公开(公告)号：EP1645841B1

公开(公告)日：2007-09-19

申请号：EP04745573.8

申请日：2004-06-03

申请人： SUMITOMO OSAKA CEMENT CO., LTD. ,  Keio University

发明人： SATO, Isao Fac. Science and Technology, Keio Univ. ,  AOKI, H. c/o Dep. of Elec.Eng. TOKYO UNIVERSITY ,  NAKAJIMA, M. Fac Science and Technology,Keio Univ. ,  MIMURA, K. Sumitomo Osaka Cement Co., Ltd. ,  TAKEMURA, Yasuhiro; Sumitomo Osaka Cement Co., Ltd ,  KATOU, Kei; Sumitomo Osaka Cement Co., Ltd. ,  TAKESUE, Toshiharu; Sumitomo Osaka Cement Co.,Ltd

IPC分类号： G01B11/25 ,  A61B5/113

CPC分类号： A61B5/1135 ,  A61B5/0064 ,  A61B5/1075 ,  A61B5/1127 ,  A61B5/1128 ,  A61B2562/0233 ,  G01B11/25

摘要： A three-dimensional shape-measuring device capable of easily and accurately grasping a condition of an object. A three-dimensional shape-measuring device is constituted of a first three-dimensional sensor (10a) having a projection device (11) for projecting pattern light to an object region and a (first) imaging device (12a) positioned with a first spacing (d1) from the projection device (11) and imaging the object region to which the pattern light is projected, a second three-dimensional sensor (10b) having the projection device (11) and a (second) imaging device (12b) positioned with a second spacing (d2), larger than the first spacing (d1), from the projection device (11) and imaging the object region to which the pattern light is projected, three-dimensional information-calculating means (22) for obtaining outline information of the object (2) based on movement of a pattern on an image obtained by the three-dimensional sensor (10a), variation information-calculating means (23) for obtaining variation information of the object (2) based on movement of a pattern on an image obtained by the second three-dimensional sensor (10b), and information-synthesizing means (24) for synthesizing the outline information and the variation information.

摘要翻译： 一种能够容易且准确地掌握物体状态的三维形状测量装置。 一个三维形状测量装置由第一三维传感器（10a）和第一成像装置（12a）构成，第一三维传感器（10a）具有用于将图形光投射到目标区域上的投影装置（11），第一成像装置（12a） （11）和第二成像装置（12b）的第二三维传感器（10b），所述第二三维传感器（10b）包括投影装置（11）和投影装置 ，从所述投影装置（11）以大于所述第一间距（d1）的第二间距（d2）对所述图案光投射到的所述被摄体区域进行成像，所述三维信息计算装置（22） 基于由三维传感器（10a）获得的图像上的图案的移动来检测物体（2）的信息;变化信息计算装置（23），用于基于移动的物体 在由图像获得的图像上的图案 cond三维传感器（10b）以及用于合成轮廓信息和变化信息的信息合成装置（24）。

公开(公告)号：EP1813294A1

公开(公告)日：2007-08-01

申请号：EP05806694.5

申请日：2005-11-17

申请人： Keio University ,  Meiji Seika Kaisha, Ltd.

发明人： IZUMI, Yotaro, School of Medicine, Keio University ,  KAWAMURA, Masafumi, School of Medicine, Keio Uni. ,  KOBAYASHI, Koichi, School of Medicine, Keio Uni.

IPC分类号： A61L31/00 ,  A61K31/785 ,  A61P7/04 ,  A61P41/00

CPC分类号： A61K31/785 ,  A61L31/06 ,  A61L31/148 ,  C08L77/04

摘要： An object of the present invention is to provide an adhesion-preventing material which is capable of effectively preventing the surfaces of organs from adhesion, and which can be absorbed in the body with high safety and produced with ease and has high practical utility, as well as to a process for preventing adhesion by using the adhesion-preventing material.
The present invention provides (1) an adhesion-preventing material comprising a crosslinked water absorbent poly-γ-glutamic acid as an effective ingredient; (2) the adhesion-preventing material described above, wherein the crosslinked water absorbent poly-γ-glutamic acid is in the form of powder having a water absorption coefficient in the range of 800 - 2000; (3) a process for preventing organ from adhesion, comprising a step of bringing the adhesion-preventing material described above into contact with the surface of a local organ; and (4) the process for preventing adhesion described above, wherein the surface of the local organ is in wet state.

摘要翻译： 本发明的一个目的是提供防粘连材料的所有其能够有效地从附着防止器官的表面上，并且可被吸收到体内具有高的安全性和生产容易并具有高的实用性，以及 作为用于通过使用防粘连材料防止粘连的方法。 本发明提供了（1）至防粘连材料包含交联的吸水性聚³谷氨酸作为有效成分; （2）防粘连材料上面介绍worin交联的吸水性聚³谷氨酸是在具有在800〜2000的范围内的水吸收系数粉末的形式; （3），用于从附着防止器官，包括使以上描述成具有局部器官的表面接触的防粘连材料的步骤的方法; 和（4），用于防止粘附上面介绍worin局部器官表面的过程是在潮湿状态。

公开(公告)号：EP1808198A1

公开(公告)日：2007-07-18

申请号：EP05805390.1

申请日：2005-10-31

申请人： Keio University ,  TERUMO KABUSHIKI KAISHA

发明人： Arai, Tsunenori Keio Univ. Fac. of Science & Tech. ,  Ohmori, Sayaka Keio Univ. Fac. of Sciece & Techn. ,  Shiono, Hiroshi c/o Terumo Kabushiki Kaisha

IPC分类号： A61N5/06

CPC分类号： A61N5/062 ,  A61B5/0059 ,  A61B2017/00057

摘要： Provided is the photodynamic therapy apparatus which is capable of detecting damage to the healthy part existing at a shallower part of a living body than the lesioned part so as to prevent disorder of the healthy part. The photodynamic therapy apparatus 10 is the photodynamic therapy apparatus 10 for treating the lesioned part existing at a deep part of a living body, using a light-sensitive substance which is activated by a light having a peak intensity within a predetermined range, but almost not activated by a light having the peak intensity out of the predetermined range, having: an irradiation device 12 which irradiates', onto the living body, pulsed light having wavelength which is capable of activating the light-sensitive substance; a detection device 14 which detects activation of the light-sensitive substance; and a control means 16 which controls the peak intensity of the light, based on result of detection obtained by the detection device 14 so that the light-sensitive substance is not activated at the healthy part existing at a shallower part than the lesioned part, and the light which reaches the lesioned part has the peak intensity within the predetermined range.

摘要翻译： 提供了能够检测对存在于生物体的较浅部位的健康部位的损伤的光动力治疗装置，以防止健康部位的紊乱。 光动力治疗装置10是使用由具有峰值强度在预定范围内但几乎不发生的光激活的感光物质来治疗存在于生物体的深部的损伤部位的光动力治疗装置10 具有：将具有峰值强度超出预定范围的光激活，具有：向生物体照射具有能够激活感光物质的波长的脉冲光的照射装置12; 检测感光物质的激活的检测装置14; 以及控制装置16，其基于由检测装置14获得的检测结果控制光的峰值强度，使得感光物质在存在于比损伤部分更浅的部分处的健康部分处未被激活，以及 到达损伤部分的光具有在预定范围内的峰值强度。