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公开(公告)号：EP1367960B1
公开(公告)日：2005-11-02
申请号：EP02709451.5
申请日：2002-01-28
CPC分类号： A61L24/06 , A61B17/8825 , A61L2430/02 , B01F15/0213 , C09J4/06 , C08L33/12
摘要： A cement mixing and delivering sytem according to the present invention includes a tube (20) having an exit nozzle (50) and an aperture. An end plate ( plate 1) is adapted to seal against the interior of the tube aperture and the end plate (plate 1) has a plurality of needles (32) protruding therefrom into the tube (20). A rotatable and slidable divider ( plates 2 & 3) is received within the tube intermediate between the end plate ( plate 1) and the exit nozzle (50). The divider includes at least two plates ( plates 2 & 3). Each of the plates ( plates 2 & 3) has a plurality of apertures ( 36 & 38) that upon alignment the needles (32) of the first plate ( plate 1) are urged through the apertures (36 & 38) of the at least two divider plates ( plates 2 & 3).
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52.发明授权
公开(公告)号：EP1165161B1
公开(公告)日：2005-11-02
申请号：EP00917740.3
申请日：2000-03-03
CPC分类号： A61M25/00 , A61M5/14 , A61M2210/0693 , A61M2230/50
摘要： A central nervous system (CNS) catheter assembly (20) adapted for use as a ventriculostomy catheter and a spinal catheter includes a catheter body (28) defining at least one lumen (30) therethrough having a drug delivery branch (22) and a monitoring/sensing branch (24). The drug delivery branch (22) and the monitoring/sensing second branch (24) are in fluid communication with the lumen (30). The assembly further includes a filter assembly (36) disposed in fluid communication with the drug delivery branch (22) and a valve assembly (54) disposed in fluid communication with the monitoring/sensing branch (24). Also in accordance with the present invention, there is provided a temperature control system (170) for use in controlling the temperature of a location within the central nervous system such as the brain or the spinal cord. The system further includes a pump controller (180), a central processing unit or controller (194), a temperature sensing element (184), and a power supply (194) all operatively connected to the temperature control mechanism.
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公开(公告)号：EP1343820A4
公开(公告)日：2005-09-14
申请号：EP01979725
申请日：2001-10-12
IPC分类号： C12N15/09 , A61K39/395 , A61K45/00 , A61K51/00 , A61K51/10 , C07K16/28 , C07K16/00 , A01N43/04 , C07H19/00 , C12P21/06
CPC分类号： A61K51/103 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/622
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公开(公告)号：EP1556137A1
公开(公告)日：2005-07-27
申请号：EP03795572.1
申请日：2003-07-16
CPC分类号： A61N1/3962 , A61N1/3622 , A61N1/3688
摘要： Methods, systems and computer program products for cardiac pacing are provided. A defibrillation shock is applied to a heart of the patient and a pacing stimulation signal is automatically applied to the heart of the patient subsequent to termination of the delivery of the defibrillation shock. The pacing stimulation may be applied to the heart of the patient within about two seconds of termination of the defibrillation shock. The pacing stimulation signal may be applied to the heart of the patient subsequent to termination of the defibrillation shock irrespective of a characterization of electrical activity detected in the heart. The pacing stimulation may be single and/or paired pacing stimulation.
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55.发明授权
公开(公告)号：EP0266119B2
公开(公告)日：2005-05-04
申请号：EP87309286.0
申请日：1987-10-21
CPC分类号： C07K16/44 , A61K9/1647 , Y02A50/412
摘要： A method and formulation for orally administering a bioactive agent which comprises encapsulating the agent in one or more biodegradable and biocompatible polymer or copolymer excipients to form a microcapsule which is capable of passing through the gastrointestinal tract unaffected and being taken up by the Peyer's patch.
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56.发明公开AN ANTIBODY SELECTIVE FOR A TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND RECEPTOR AND USES THEREOF 有权为肿瘤坏死因子相似，细胞凋亡诱导配体受体的选择性抗体及其应用
公开(公告)号：EP1287035A4
公开(公告)日：2004-09-29
申请号：EP01932876
申请日：2001-05-02
IPC分类号： C12N15/02 , A61K31/337 , A61K39/395 , A61K45/06 , A61P1/04 , A61P3/10 , A61P5/18 , A61P7/06 , A61P9/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P21/04 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/08 , A61P43/00 , C07D305/14 , C07H21/02 , C07K16/00 , C07K16/28 , C07K16/30 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12P21/08 , A01N43/04
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/2878 , C07K16/30 , C07K2317/24 , C07K2317/73 , C07K2319/00 , C07K2319/30 , G01N33/6863
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公开(公告)号：EP1367960A4
公开(公告)日：2004-06-09
申请号：EP02709451
申请日：2002-01-28
发明人： PUCKETT AARON D JR , LEMONS JACK , BU LUJIA , MAYS JIMMY W
CPC分类号： A61L24/06 , A61B17/8825 , A61L2430/02 , B01F15/0213 , C09J4/06 , C08L33/12
摘要： A cement mixing and delivering sytem according to the present invention includes a tube (20) having an exit nozzle (50) and an aperture. An end plate ( plate 1) is adapted to seal against the interior of the tube aperture and the end plate (plate 1) has a plurality of needles (32) protruding therefrom into the tube (20). A rotatable and slidable divider ( plates 2 & 3) is received within the tube intermediate between the end plate ( plate 1) and the exit nozzle (50). The divider includes at least two plates ( plates 2 & 3). Each of the plates ( plates 2 & 3) has a plurality of apertures ( 36 & 38) that upon alignment the needles (32) of the first plate ( plate 1) are urged through the apertures (36 & 38) of the at least two divider plates ( plates 2 & 3).
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公开(公告)号：EP1414500A2
公开(公告)日：2004-05-06
申请号：EP02731374.1
申请日：2002-04-16
发明人： MOUNTZ, John, D. , ZHANG, Huang-Ge , XIE, Jin-Fu , LIANG, Xu , YANG, Pingar , HSU, Hui-Chen
CPC分类号： A61K31/635 , A61K31/366 , A61K31/4439 , A61K31/506 , A61K31/5377 , A61K31/585 , A61K48/00
摘要： The administration of an Akt inhibitor in a suitable carrier to a rheumatoid arthritis synovial fibroblast affords a process for inducing rheumatoid arthritis synovial fibroblast apoptosis. The Akt inhibitor is administered either as an active molecule or as a gene sequence expressible within rheumatoid arthritis synovial fibroblast cells. The gene sequence can be encompassed within a gene vector such as an adenovirus. A process for assaying rheumatoid arthritis drug candidates for apoptosis affect includes exposing a culture of rheumatoid arthritis synovial fibroblast cells to a drug candidate and monitoring apoptosis in the culture in the presence of the drug candidate. Apoptosis in the culture is compared to apoptosis induced in a duplicate culture in the presence of a known Akt inhibitor.
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公开(公告)号：EP1200123A4
公开(公告)日：2003-05-02
申请号：EP00926105
申请日：2000-04-19
发明人： SONTHEIMER HARALD J , LYONS SUSAN A
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K45/00 , A61K47/48 , A61P35/00 , C07K16/28 , G01N33/566 , G01N33/574 , A01N37/18
CPC分类号： G01N33/57407 , A61K47/6415 , A61K2039/505 , C07K16/28 , G01N33/57492 , G01N2333/705 , Y10S436/813
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60.发明公开
公开(公告)号：EP1181929A3
公开(公告)日：2003-04-23
申请号：EP01128930.3
申请日：1989-03-20
发明人： Tice, Thomas , Eldrige, John , Gilley, Richard , Stass, Jay
IPC分类号： A61K9/16
CPC分类号： A61K31/216 , A61K9/1635 , A61K9/1647 , A61K38/00 , A61K39/085 , A61K39/12 , A61K39/39 , A61K2039/541 , A61K2039/545 , A61K2039/55555 , C12N2770/24134 , Y02A50/412 , Y10S514/885 , Y10S514/963 , Y10T428/2985 , Y10T428/2989
摘要： A method, and compositions for use therein capable, of delivering a bioactive agent to an animal entailing the steps of encapsulating effective amounts of the agent in a biocompatible excipient to form microcapsules having a size less than approximately ten micrometers and administering effective amounts of the microcapsules to the animal. A pulsatile response is obtained, as well as mucosal and systemic immunity.
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