公开(公告)号：EP1210100B1

公开(公告)日：2006-06-14

申请号：EP00955437.9

申请日：2000-08-10

申请人： UAB RESEARCH FOUNDATION

发明人： MEYTHALER, Jay, M. ,  PEDUZZI, Jean

IPC分类号： A61K38/00 ,  A61K31/60

CPC分类号： A61K31/60 ,  A61K31/609 ,  A61K38/17 ,  A61K45/06 ,  A61K2300/00

摘要： A method for treating a patient/subject having neuronal injury, pain, neurotrauma and/or traumatic brain injury, such as diffuse axonal injury, which includes intrathecally and/or intraventricularly administering to the subject a therapeutically effective amount of a non-steroidal anti-inflammatory drug and/or a naturally occurring omega conotoxin, functional fragment thereof, a pharmacologically acceptable salt, ester, amide, or prodrug thereof.

公开(公告)号：EP1210100A1

公开(公告)日：2002-06-05

申请号：EP00955437.9

申请日：2000-08-10

申请人： UAB Research Foundation

发明人： MEYTHALER, Jay, M. ,  PEDUZZI, Jean

IPC分类号： A61K38/00 ,  A61K31/60

CPC分类号： A61K31/60 ,  A61K31/609 ,  A61K38/17 ,  A61K45/06 ,  A61K2300/00

摘要： A method for treating a patient/subject having neuronal injury, pain, neurotrauma and/or traumatic brain injury, such as diffuse axonal injury, which includes intrathecally and/or intraventricularly administering to the subject a therapeutically effective amount of a non-steroidal anti-inflammatory drug and/or a naturally occurring omega conotoxin, functional fragment thereof, a pharmacologically acceptable salt, ester, amide, or prodrug thereof.

公开(公告)号：EP1165161A1

公开(公告)日：2002-01-02

申请号：EP00917740.3

申请日：2000-03-03

申请人： UAB Research Foundation

发明人： MEYTHALER, Jay, M. ,  PEDUZZI, Jean ,  MILLER, Landon, C., G.

IPC分类号： A61M5/00 ,  A61M25/00

CPC分类号： A61M25/00 ,  A61M5/14 ,  A61M2210/0693 ,  A61M2230/50

摘要： A central nervous system (CNS) catheter assembly (20) adapted for use as a ventriculostomy catheter and a spinal catheter includes a catheter body (28) defining at least one lumen (30) therethrough having a drug delivery branch (22) and a monitoring/sensing branch (24). The drug delivery branch (22) and the monitoring/sensing second branch (24) are in fluid communication with the lumen (30). The assembly further includes a filter assembly (36) disposed in fluid communication with the drug delivery branch (22) and a valve assembly (54) disposed in fluid communication with the monitoring/sensing branch (24). Also in accordance with the present invention, there is provided a temperature control system (170) for use in controlling the temperature of a location within the central nervous system such as the brain or the spinal cord. The system further includes a pump controller (180), a central processing unit or controller (194), a temperature sensing element (184), and a power supply (194) all operatively connected to the temperature control mechanism.

公开(公告)号：EP1165161B1

公开(公告)日：2005-11-02

申请号：EP00917740.3

申请日：2000-03-03

申请人： UAB RESEARCH FOUNDATION

发明人： MEYTHALER, Jay, M. ,  PEDUZZI, Jean ,  MILLER, Landon, C., G.

IPC分类号： A61M5/00 ,  A61M25/00 ,  A61M27/00

CPC分类号： A61M25/00 ,  A61M5/14 ,  A61M2210/0693 ,  A61M2230/50

摘要： A central nervous system (CNS) catheter assembly (20) adapted for use as a ventriculostomy catheter and a spinal catheter includes a catheter body (28) defining at least one lumen (30) therethrough having a drug delivery branch (22) and a monitoring/sensing branch (24). The drug delivery branch (22) and the monitoring/sensing second branch (24) are in fluid communication with the lumen (30). The assembly further includes a filter assembly (36) disposed in fluid communication with the drug delivery branch (22) and a valve assembly (54) disposed in fluid communication with the monitoring/sensing branch (24). Also in accordance with the present invention, there is provided a temperature control system (170) for use in controlling the temperature of a location within the central nervous system such as the brain or the spinal cord. The system further includes a pump controller (180), a central processing unit or controller (194), a temperature sensing element (184), and a power supply (194) all operatively connected to the temperature control mechanism.

公开(公告)号：EP1296720A2

公开(公告)日：2003-04-02

申请号：EP01928531.1

申请日：2001-04-13

申请人： THE UAB RESEARCH FOUNDATION

发明人： MORROW, Casey, D. ,  JACKSON, Cheryl ,  PEDUZZI, Jean

IPC分类号： A61K48/00 ,  C12N15/86 ,  A61P25/00 ,  A61P35/00 ,  A61P31/04

CPC分类号： A61K39/105 ,  A61K38/191 ,  A61K48/00 ,  A61K2039/5256 ,  C12N15/86 ,  C12N2770/32634 ,  C12N2770/32643 ,  Y02A50/466

摘要： The invention pertains to methods of delivering a polypeptide to a cell comprising (a) contacting a cell with a replicon having a non-poliovirus nucleic acid substituted for a nucleic acid which encodes at least a portion of a protein necessary for encapsidation, the non-poliovirus nucleic acid encoding, in an expressible form, a polypeptide or fragment thereof; and (b) maintaining the cells under conditions appropriate for introduction of the replicons into the cells. The cell may be within a subject and the polypeptide may be a therapeutic agent. The methods of the invention may be used to treat diseases including central nervous system disorders, infectious diseases, and cancer.

公开(公告)号：EP1202720A1

公开(公告)日：2002-05-08

申请号：EP00955436.1

申请日：2000-08-10

申请人： UAB Research Foundation

发明人： MEYTHALER, Jay, M. ,  PEDUZZI, Jean

IPC分类号： A61K31/13 ,  A61K31/195

CPC分类号： A61K31/165 ,  A61K31/00 ,  A61K31/16 ,  A61M5/14276

摘要： According to the subject invention, there is disclosed a method for treating a patient/subject having a spastic disorder, a convulsive disorder, pain or epilepsy which includes administering to the subject having any one of these conditions a therapeutically effective amount of the compound gamma-aminobutyramide, analogs, substituted forms, derivatives, the pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, or compounds which yield gamma-aminobutyramide as an intermediate, a metabolite, or a by-product.