公开(公告)号：EP2032690A2

公开(公告)日：2009-03-11

申请号：EP07725549.5

申请日：2007-05-25

申请人： Eberhard-Karls-Universität Tübingen

发明人： LEMBERT, Nicolas

IPC分类号： C12N5/06

CPC分类号： C12N5/0676 ,  C12N2509/00

摘要： The invention relates to a method for the in vitro preparation of living cells and/or cell accumulations from tissue and/or organs. According to said method, tissue and/or organic material containing the relevant cells is/are first prepared, the tissue is then treated to obtain at least partially fragmented and/or degraded tissue and/or organ material, said treatment being carried out in a container. In a subsequent step, a liquid medium is added to the tissue material/organ material from the previous step, to elute parts of the tissue and/or organ material from the container into a bag of the cell processor, the container and the bag being connected in such a way that they form a sealed system. Finally, the bag is centrifuged in the cell processor, the supernatant liquid is removed to obtain a concentrate containing the relevant cells and the concentrate is purified in the cell processor using a density gradient.

公开(公告)号：EP2027255A2

公开(公告)日：2009-02-25

申请号：EP07724981.1

申请日：2007-05-08

申请人： Eberhard-Karls-Universität Tübingen Universitätsklinikum

发明人： WENDEL, Hans-Peter ,  GUO, Ketai ,  SCHAEFER, Richard

IPC分类号： C12N5/00

CPC分类号： C12N15/111 ,  C12N5/0663 ,  C12N15/115 ,  C12N2310/3517 ,  C12N2320/11 ,  C12N2320/13

摘要： The invention relates to: a device comprising a surface that comes into contact with biological tissue and/or with liquid, said surface being coated at least partially with a substance that mediates the binding of mesenchymal stem cells (MSC); a method for binding and/or isolating MSC from biological tissue and/or liquid; a nucleic acid molecule that binds to MSC in a selective and highly-specific manner; the use of the nucleic acid molecule for binding and/or isolating MSC from biological tissue and/or liquid; and to a method for producing a device of this type.

公开(公告)号：EP2013361A2

公开(公告)日：2009-01-14

申请号：EP07724322.8

申请日：2007-04-18

申请人： Eberhard-Karls-Universität Tübingen Universitätsklinikum

发明人： SIMON, Perikles

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6888 ,  C12Q2600/16

摘要： The present invention relates to a method for the detection of transgenic DNA (tDNA) in a living being and to a kit for performing such a method.

公开(公告)号：EP1996694A1

公开(公告)日：2008-12-03

申请号：EP06829576.5

申请日：2006-12-13

申请人： Eberhard-Karls-Universität Tübingen Universitätsklinikum

发明人： SCHMIDT, Timo ,  JUST, Lothar

IPC分类号： C12M3/00 ,  C12N5/00

CPC分类号： C12M35/04 ,  C12M23/04 ,  C12M29/06 ,  C12M35/02

摘要： The invention relates to a device and a method for cultivating and producing biological material.

公开(公告)号：EP1901063A2

公开(公告)日：2008-03-19

申请号：EP07017866.0

申请日：2007-09-12

申请人： Eberhard-Karls-Universität Tübingen

发明人： Bühring, Hans-Jörg, Dr. ,  Lammers, Reiner, Dr. ,  Treml, Sabrina ,  Battula, Venkata Lokesh

IPC分类号： G01N33/50

CPC分类号： G01N33/577 ,  A61K35/28 ,  C07K16/28 ,  C07K16/2863 ,  C07K16/3015 ,  C07K16/32 ,  G01N33/6887 ,  G01N2333/705

摘要： The present invention concerns the use of an antibody, or functional fragments thereof, for isolating and/or identifying homogenous mesenchymal stem cells from primary tissues. Furthermore a method is presented with which mesenchymal stem cells from adult primary tissue, for example bone marrow, can be identified and isolated with a high level of purity.

公开(公告)号：EP1802749A2

公开(公告)日：2007-07-04

申请号：EP05797320.8

申请日：2005-09-27

申请人： GSF-FORSCHUNGSZENTRUM FÜR UMWELT UND GESUNDHEIT, GMBH ,  Eberhard Karls Universität Tübingen ,  Mayo Clinic

发明人： MEITINGER, Thomas ,  STROM, Tim, Matthias ,  BISKUP, Saskia ,  UEFFING, Marius ,  KREMMER, Elisabeth ,  GLOECKNER, Christian, J. ,  GASSER, Thomas ,  LEITNER, Petra ,  ASMUS, Friedrich ,  PATENGE, Nadja ,  ZIMPRICH, Alexander ,  FARRER, Matthew, J. ,  KACHERGUS, Jennifer, M. ,  LINCOLN, Sara, J. ,  HULIHAN, Mary, M. ,  WSZOLEK, Zibigniew ,  UITTI, Ryan

IPC分类号： C12N9/12

CPC分类号： C12N9/1205

摘要： The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.

公开(公告)号：EP1781317A1

公开(公告)日：2007-05-09

申请号：EP05782884.0

申请日：2005-08-19

申请人： Eberhard-Karls-Universität Tübingen

发明人： STUHLER, Gernot ,  SALIH, Helmut

IPC分类号： A61K38/16 ,  C12Q1/48 ,  C12Q1/00

CPC分类号： G01N33/57496 ,  A61K38/16 ,  A61K38/43 ,  C12Q1/485

摘要： The present invention relates to a therapeutic or/and diagnostic substance. Furthermore it relates to an expression vector, to a composition comprising the afore-mentioned substance or/and the afore-mentioned expression vector, a method for diagnosing a tumor disease or/and an infectious disease in a living being, as well as to a method for the treatment of a tumor disease or/and of an infection in a living being.

公开(公告)号：EP1634603A1

公开(公告)日：2006-03-15

申请号：EP04020259.0

申请日：2004-08-26

申请人： Eberhard-Karls-Universität Tübingen Universitätsklinikum

发明人： Stuhler, Gernot, Dr. ,  Salih, Helmut, Dr.

IPC分类号： A61K38/00 ,  C12Q1/48 ,  C12Q1/00

CPC分类号： G01N33/57496 ,  A61K38/16 ,  A61K38/43 ,  C12Q1/485

摘要： Die vorliegende Erfindung betrifft eine therapeutische oder/und diagnostische Substanz. Weiter betrifft sie einen Expressionsvektor, die Verwendung der Substanz oder/und des Expressionsvektors zur Herstellung einer pharmazeutischen Zusammensetzung, eine Zusammensetzung, ein Verfahren zur Diagnose einer Tumorerkrankung oder/und einer Infektion bei einem Lebewesen sowie ein Verfahren zur Behandlung einer Tumorerkrankung oder/und Infektion bei einem Lebewesen (Fig. 1).

摘要翻译： 一种治疗或/和诊断物质（I），其与至少两个大部分同时出现在转化或/和感染的生物细胞中的分子间接或直接反应，其中所述反应导致生物或/和可检测物质的诱导 财产，是新的。 还包括独立权利要求：（1）编码（I）的表达载体; （2）在转化和/或感染的细胞中唯一诱导生物学和/或可检测性质的组合物; （3）通过分析生物样品中单细胞中分子的外观来诊断活体中的癌症和/或感染，并将样品单细胞中同时出现的分子的发现与专一出现在转化的和 /或基本上同时进行感染的生物细胞，并进行阳性诊断。 活动：细胞抑制 抗菌。 没有给出生物数据。 行动机制：无。

公开(公告)号：EP1463610A1

公开(公告)日：2004-10-06

申请号：EP03704345.2

申请日：2003-01-02

申请人： Eberhard-Karls-Universität Tübingen Universitätsklinikum

发明人： LANGER, Matthias ,  LÖFFLER, Karsten

IPC分类号： B25J7/00

CPC分类号： B81C99/002 ,  B25J7/00

摘要： The invention relates to a force measurement and gripper device (10) for sampling and/or gripping nanometric objects in different media. Said device comprises a first and second arm (12, 14), which are arranged at a distance from one another and run essentially parallel, each arm having a longitudinal axis (L1, L2), a first and second gripper and force measurement unit (41, 43), said first measurement unit (41) being allocated to the first arm (12) and the second measurement unit (43) being allocated to the second arm (14), whereby at least one measurement unit can be displaced perpendicularly to the longitudinal axis. According to the invention, the two arms are interconnected by means of an articulated element (18, 54), the latter (18, 54) dividing the two arms into a first and a second longitudinal section (21, 22) and the articulated element (18, 54) is configured in such a way that it allows a pivotal displacement of at least one arm (12, 14) about the articulated element (18, 54) and thus a displacement of one measurement unit (41, 43) on a plane, which is parallel to the longitudinal axes of both arms.

公开(公告)号：EP1150705B1

公开(公告)日：2004-05-26

申请号：EP00907521.9

申请日：2000-02-08

申请人： Eberhard-Karls-Universität Tübingen Universitätsklinikum

发明人： DITTMANN, Klaus ,  GÜVEN, Nuri ,  MAYER, Claus ,  RODEMANN, H., Peter

IPC分类号： A61K38/56 ,  A61K48/00 ,  A61K47/48 ,  A61P43/00

CPC分类号： A61K38/57 ,  A61K48/00

摘要： The invention relates to the utilization of a peptide for the protection of cells in connection with an in vivo and/or in vitro treatment with chemical agents. Said peptide comprises a modified form and/or optionally a modified fragment of a Bowman-Birk protease inhibitor (BBI). The invention also relates to the utilization of nucleic acid for the protection of cell in connection with an in vivo and/or in vitro treatment with chemical agents, wherein the nucleic acid comprises a sequence segment coding for the at least one peptide mentioned above.