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344 条记录 (耗时 0.022 秒)

    PROTEOMIC ANALYSIS OF CERVICAL-VAGINAL FLUIDS FOR DETECTING INTRA-UTERINE INFECTION OR DETERMINING PRE-TERM DELIVERY RISK IN A PREGNANT FEMALE
    51.
    发明授权
    PROTEOMIC ANALYSIS OF CERVICAL-VAGINAL FLUIDS FOR DETECTING INTRA-UTERINE INFECTION OR DETERMINING PRE-TERM DELIVERY RISK IN A PREGNANT FEMALE 有权
    蛋白质组分析液体在子宫和阴道用于识别宫内感染或确定早产低的风险第二次降临孕妇

    公开(公告)号：EP2092344B1

    公开(公告)日：2011-06-15

    申请号：EP07871428.4

    申请日：2007-11-09

    申请人： Hologic, Inc.

    发明人： ROSENFELD, Ron ,  NAGALLA, Srinivasa ,  GRAVETT, Mike

    IPC分类号： G01N33/68

    CPC分类号： G01N33/689 ,  G01N2800/368 ,  Y02A90/26

    摘要： The invention concerns the identification of proteomes of biological fluids and their use in determining the state of maternal/fetal conditions, including maternal conditions of fetal origin, chromosomal aneuploidies, and fetal diseases associated with fetal growth and maturation. In particular, the invention concerns a comprehensive proteomic analysis of human amniotic fluid (AF) and cervical vaginal fluid (CVF), and the correlation of characteristic changes in the normal proteome with various pathologic maternal/fetal conditions, such as intra-amniotic infection, pre-term labor, and/or chromosomal defects. The invention further concerns the identification of biomarkers and groups of biomarkers that can be used for non-invasive diagnosis of various pregnancy-related disorders, and diagnostic assays using such biomarkers.

    Methods for detection of a target nucleic acid sequence
    53.
    发明公开
    Methods for detection of a target nucleic acid sequence 审中-公开
    Verfahren zur Detektion einerZielnukleinsäuresequenz

    公开(公告)号：EP2298935A1

    公开(公告)日：2011-03-23

    申请号：EP10179704.1

    申请日：2000-10-27

    申请人： Hologic Inc.

    发明人： Sorge, Joseph, A.

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/686 ,  C12Q1/6823 ,  Y10S435/81 ,  Y10S435/822 ,  Y10T436/143333 ,  C12Q2561/109 ,  C12Q2531/113

    摘要： The invention relates to a method of generating a signal indicative of the presence of a target nucleic acid sequence in a sample, where the method includes forming a cleavage structure by incubating a sample containing a target nucleic acid sequence with a nucleic acid polymerase and cleaving the cleavage structure with an FEN nuclease to generate a cleaved nucleic acid fragment. The invention also relates to methods of detecting or measuring a target nucleic acid sequence, where the method includes forming a cleavage structure by incubating a target nucleic acid sequence with a nucleic acid polymerase, cleaving the cleavage structure with an FEN nuclease and detecting or measuring the release of a fragment.

    摘要翻译： 本发明涉及一种产生指示样品中目标核酸序列存在的信号的方法，其中该方法包括通过将含有靶核酸序列的样品与核酸聚合酶一起孵育而形成切割结构， 用FEN核酸酶切割结构以产生切割的核酸片段。 本发明还涉及检测或测量靶核酸序列的方法，其中该方法包括通过将靶核酸序列与核酸聚合酶孵育形成切割结构，用FEN核酸酶切割切割结构，并检测或测量 释放片段。

    Amorphous selenium flat panel x-ray imager for tomosynthesis and static imaging
    56.
    发明公开
    Amorphous selenium flat panel x-ray imager for tomosynthesis and static imaging 审中-公开
    用于断层合成和静态成像的非晶硒平板X射线成像仪

    公开(公告)号：EP1850388A3

    公开(公告)日：2008-10-29

    申请号：EP07251764.2

    申请日：2007-04-26

    申请人： HOLOGIC, INC.

    发明人： Cheung, Lawrence ,  Bogdanovich, Snezana ,  Ingal, Elena ,  Williams, Cornell L.

    IPC分类号： H01L27/146

    CPC分类号： H01L27/14676 ,  G01T1/24 ,  G01T1/244 ,  H01L27/14665

    摘要： A flat panel x-ray imager exhibiting reduced ghosting effects and overvoltage protection by appropriate leakage current characteristics of the thin-film transistor array. A top electrode of a suitable material is directly on an amorphous selenium-based charge generator layer allowing charge transport across the layer, thereby reducing ghosting. Alternatively, a non-insulating organic layer may be between the top electrode and the charge generating layer. The thin-film transistors have leakage current that rises relatively slowly with voltage across the transistor within a range that matches exposure through an object being imaged but rises at a sufficiently higher rate within a higher range to provide protection even when a corresponding region of the charge generator layer receives greater amounts of x-rays. A voltage is applied to the top electrode. This voltage may be within the range of 500 V to 2,000 V.

    摘要翻译： 通过薄膜晶体管阵列的适当泄漏电流特性表现出减少的重影效应和过压保护的平板x射线成像仪。 合适材料的顶部电极直接位于非晶硒基电荷发生器层上，允许电荷跨层传输，从而减少鬼影。 或者，非绝缘有机层可以位于顶电极和电荷产生层之间。 薄膜晶体管的漏电流随着晶体管两端的电压在与通过成像对象的曝光匹配的范围内升高相对缓慢，但在更高范围内以足够高的速率升高以提供保护，即使当电荷的相应区域 发生器层接收更多的X射线。 电压被施加到顶部电极。 该电压可以在500V至2000V的范围内。

    Amorphous selenium flat panel x-ray imager for tomosynthesis and static imaging
    57.
    发明公开
    Amorphous selenium flat panel x-ray imager for tomosynthesis and static imaging 审中-公开
    Flachbildschirm-Röntgenbildgebungsvorrichtungmit amorphem SelenfürTomosynthese und statische Bildgebung

    公开(公告)号：EP1693893A2

    公开(公告)日：2006-08-23

    申请号：EP06250842.9

    申请日：2006-02-16

    申请人： HOLOGIC, INC.

    发明人： Jing, Zhenxue ,  Cheung, Lawrence

    IPC分类号： H01L27/146

    CPC分类号： H01L27/14676 ,  H01L31/115

    摘要： A flat panel x-ray imager exhibiting reduced ghosting effects and overvoltage protection by appropriate leakage current characteristics of the thin-film transistor array. A top electrode of a suitable material is directly on and in physical and electrical contact with an amorphous selenium-based charge generator layer, thereby reducing ghosting. The thin-film transistors have leakage current that rises relatively slowly with voltage across the transistor within a range that matches exposure through an object being imaged but rises at a sufficiently higher rate within a higher range to provide protection even when a corresponding region of the charge generator layer receives greater amounts of x-rays.

    摘要翻译： 平板X射线成像仪通过薄膜晶体管阵列的适当的泄漏电流特性显示出减少的重影效应和过电压保护。 合适材料的顶部电极直接与非晶硒基电荷发生器层物理和电接触，从而减少重影。 薄膜晶体管的漏电流与跨越晶体管的电压相对缓慢地升高，该范围通过被成像的物体的曝光相匹配的范围，但是在更高的范围内以足够高的速率上升，甚至在相应的电荷区域 发电机层接收更大量的X射线。