公开(公告)号：EP2773455B1

公开(公告)日：2019-04-10

申请号：EP12845215.8

申请日：2012-11-01

Applicant: Purdue Research Foundation

Inventor： WIRTH, Mary, J. ,  HUA, Yimin ,  ZHANG, Zhaorui

IPC: B01J20/32 ,  B01J20/28 ,  B01D15/38 ,  G01N30/56 ,  C07K1/22

公开(公告)号：EP2968335B1

公开(公告)日：2019-03-27

申请号：EP13878809.6

申请日：2013-08-26

Applicant: Purdue Research Foundation

Inventor： LOW, Philip S. ,  KULARATNE, Sumith A. ,  MAHALINGAM, Sakkarapalayam M.

IPC: C07D475/04 ,  A61K49/00 ,  A61P35/00 ,  G01N33/566

公开(公告)号：EP3429575A1

公开(公告)日：2019-01-23

申请号：EP17767563.4

申请日：2017-03-16

Applicant: Purdue Research Foundation

Inventor： LOW, Philip S. ,  LU, Pengcheng

IPC: A61K31/18 ,  A61K51/04

公开(公告)号：EP3388086A1

公开(公告)日：2018-10-17

申请号：EP18175078.7

申请日：2008-08-15

Applicant: Purdue Research Foundation

Inventor： LOW, Philip, Stewart ,  KULARATNE, Sumith, A.

IPC: A61K49/00

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：EP2694707B1

公开(公告)日：2018-08-15

申请号：EP12842368.8

申请日：2012-04-09

Applicant: Cornell University ,  Purdue Research Foundation

Inventor： BARANY, Francis ,  PINGLE, Maneesh ,  BERGSTROM, Donald E. ,  GIARDINA, Sarah, Filippa ,  ARNOLD, Lee, Daniel

IPC: C07D409/06 ,  C07D491/107 ,  C07D211/26 ,  C07D405/06 ,  A61K31/422 ,  A61P29/00

CPC classification number: C07D211/26 ,  C07D405/06 ,  C07D409/06 ,  C07D491/107 ,  C07F5/025 ,  C07F5/04

Abstract: Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.

公开(公告)号：EP3356802A1

公开(公告)日：2018-08-08

申请号：EP16849904.4

申请日：2016-09-27

Applicant: Purdue Research Foundation

Inventor： SIMPSON, Garth, Jason ,  SCHMITT, Paul, David ,  GRIFFIN, Scott, Robert ,  SMITH, Casey, Jake

IPC: G01N21/70 ,  G01N21/00 ,  G01N21/01 ,  G01N21/62

CPC classification number: G01N21/70 ,  G01N21/01

Abstract: An impact-driven apparatus and method to achieve triboluminescence of homochiral API crystals as a measurement tool for rapidly assessing the presence of trace crystallinity within nominally amorphous pharmaceutical powders. The apparatus may include a kinetic energy director and two plates which hold a sample for testing. The triboluminescence may also be achieve by an acoustic transducer.

公开(公告)号：EP3155640A4

公开(公告)日：2018-07-04

申请号：EP15809806

申请日：2015-06-16

Applicant: PURDUE RESEARCH FOUNDATION ,  COOKS ROBERT GRAHAM ,  BAIRD ZANE ,  WEI PU

Inventor： COOKS ROBERT GRAHAM ,  BAIRD ZANE ,  WEI PU

IPC: H01J49/06 ,  G01N27/62 ,  H01J49/00

CPC classification number: H01J49/24 ,  G01N27/622 ,  H01J49/0013 ,  H01J49/061 ,  H01J49/142

Abstract: The invention generally relates to sample analysis systems and methods of use thereof. In certain aspects, the invention provides a system for analyzing a sample that includes an ion generator configured to generate ions from a sample. The system additionally includes an ion separator configured to separate at or above atmospheric pressure the ions received from the ion generator without use of laminar flowing gas, and a detector that receives and detects the separated ions.

公开(公告)号：EP3185922A4

公开(公告)日：2018-04-25

申请号：EP15835953

申请日：2015-08-27

Applicant: PURDUE RESEARCH FOUNDATION OFFICE OF TECH COMMERCIALIZATION

Inventor： VOYTIK-HARBIN SHERRY

IPC: A61L27/24 ,  A61L27/54 ,  A61L31/04

CPC classification number: A61L27/24 ,  A61K9/0024 ,  A61K9/19 ,  A61K38/18 ,  A61K47/42 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/604 ,  A61L2400/06

Abstract: A collagen-based therapeutic delivery device includes an insoluble synthetic collagen-fibril matrix comprising a polymerization product of soluble oligomeric collagen or a polymerization product of a mixture of soluble oligomeric collagen with one or more type of non-oligomeric soluble collagen molecules, such as, for example, soluble telocollagen and/or soluble atelocollagen, and an active agent dispersed throughout the collagen-fibril matrix or within a portion of the collagen-fibril matrix. A pre-matrix composition includes an aqueous solution including soluble collagen-fibril building blocks and an active agent in the aqueous solution. The soluble collagen-fibril building blocks include soluble oligomeric collagen or a mixture of soluble oligomeric collagen with non-oligomeric soluble collagen molecules. The building blocks are operable to self-assemble into a macromolecular synthetic collagen-fibril matrix in the absence of an exogenous cross-linking agent. Methods of making and using the pre-matrix composition and the device are also provided.

公开(公告)号：EP3267672A1

公开(公告)日：2018-01-10

申请号：EP17179824.2

申请日：2017-07-05

Applicant: Hewlett-Packard Development Company L.P. ,  Purdue Research Foundation

Inventor： TANG, Chuohao ,  COLLISON, Sean ,  REIBMAN, Amy Ruth ,  SHAW, Mark ,  ALLEBACH, Jan ,  GONDEK, Jay. S.

IPC: H04N1/60 ,  H04N1/00 ,  H04N1/41

CPC classification number: H04N1/648 ,  B41J2/17546 ,  H04N1/00538 ,  H04N1/41 ,  H04N1/6008 ,  H04N1/6019 ,  H04N1/6052 ,  H04N1/644 ,  H04N2201/0087

Abstract: A print cartridge includes a memory device with data to reconstruct a color table for a printing device. The data include a compressed bitstream stored in the memory device with a plurality of quantized coefficients from a lossy compression of a plurality of difference nodes of a difference color table at a selected step size. The value of each node in the difference color table is to be added to the corresponding node in the value of a corresponding node of a reference table stored on the printing device. Corrective information for a set of nodes to be modified with residual values is included. The quantized coefficients and the corrective information are compressed. The step size information is also included.

Abstract translation: 打印盒包括具有数据的存储设备以重建打印设备的颜色表。 数据包括存储在存储装置中的压缩比特流，其具有来自差分颜色表的多个差分节点在选定步长下的有损压缩的多个量化系数。 差异颜色表中的每个节点的值将被添加到存储在打印设备上的参考表的相应节点的值中的相应节点上。 包括用残差值修改一组节点的纠正信息。 量化系数和校正信息被压缩。 步长信息也包括在内。

公开(公告)号：EP3242670A1

公开(公告)日：2017-11-15

申请号：EP16735490.1

申请日：2016-01-08

Applicant: Purdue Research Foundation

Inventor： WON, You-Yeon ,  LEE, Jaewon

IPC: A61K33/24 ,  A61K9/51

Abstract: The invention relates generally to a formulation in which metal tungstate or metal molybdate particles are encapsulated within biocompatible, diseased cell-targeting polymeric coatings. Such formulations render metal tungstate or metal molybdate particles suitable for in vivo biomedical imaging and therapeutic applications.