公开(公告)号：EP1680083A1

公开(公告)日：2006-07-19

申请号：EP04817488.2

申请日：2004-10-29

申请人： ALZA CORPORATION

发明人： WONG, Patrick, S., L. ,  YAN, Dong ,  GUITTARD, George, V.

IPC分类号： A61K9/00 ,  A61K31/20 ,  A61K33/26 ,  A61P7/06 ,  C07C53/126

CPC分类号： A61K31/662 ,  A61K9/0004 ,  A61K31/155 ,  A61K31/185 ,  A61K31/195 ,  A61K31/197 ,  A61K31/198 ,  A61K31/20 ,  A61K31/295 ,  A61K31/66 ,  A61K33/26 ,  A61K47/541 ,  A61K47/585 ,  A61K2300/00

摘要： A complex comprised of iron and a transport moiety, such as a fatty acid, is described. The complex has an enhanced absorption in the gastrointestinal tract, particularly the lower gastrointestinal tract. The complex, and compositions and dosage forms prepared using the complex, provide for absorption by the body of iron through a period of ten to twenty-four hours, thus enabling a true one-daily dosage form for iron.

公开(公告)号：EP1678293A2

公开(公告)日：2006-07-12

申请号：EP04796003.4

申请日：2004-10-21

申请人： ALZA CORPORATION

发明人： CORMIER, Michel, J., N. ,  WIDERA, Georg ,  AMERI, Mahmoud

IPC分类号： C12N1/00

CPC分类号： A61K48/0008 ,  A61K48/0025 ,  A61K48/0041 ,  C12N15/89

摘要： The present invention provides methods and compositions for stabilizing dried nucleic acids with carbohydrates such as non-reducing sugars, polysaccharides, and reducing sugars. Preferably, the stabilized nucleic acids are coated on a microprojection member for transdermal delivery. The invention further provides compositions and methods that involve the use of DNase inhibitors to stabilize dried nucleic acids delivered directly into bodily tissues.

公开(公告)号：EP1300173B1

公开(公告)日：2006-06-14

申请号：EP02080491.0

申请日：1998-12-15

申请人： ALZA CORPORATION

发明人： Davis, Craig R. ,  Peery, John R.

IPC分类号： A61M37/00 ,  A61M36/12

CPC分类号： A61M37/0069 ,  A61J1/00

公开(公告)号：EP1666026A2

公开(公告)日：2006-06-07

申请号：EP06075430.6

申请日：2000-02-02

申请人： ALZA CORPORATION

发明人： Berry, Stephan ,  Fereira, Pamela J. ,  Dehnad, Houdin ,  Muchnik, Anna

IPC分类号： A61K9/10

CPC分类号： A61K9/0024 ,  A61K9/0004 ,  A61K9/19 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/32 ,  A61K47/44

摘要： There is disclosed a non-aqueous single phase biocompatible viscous vehicle capable of suspending a beneficial agent and dispensing the beneficial agent over an extended period of time at body temperature. The vehicle comprises solvent, surfactant, and polymer. The solvent, surfactant and polymer are not the same. The solvent is lauryl alcohol or lauryl lactate, the surfactant is selected from the group consisting of esters of polyhydric alcohols, ethoxylated castor oil, polysorbates, esters or ethers of saturated alcohols, and polyoxyethylenepolyoxypropylene block copolymers, and the polymer is selected from the group consisting of polyesters, pyrrolidones, esters or ethers of unsaturated alcohols, and polyoxyethylenepolyoxypropylene block copolymers.

摘要翻译： 有游离缺失的非水单相生物相容性粘性能够悬浮的有益剂和过分配有益剂上在体温下在延长的时间期间的车辆光盘。 该车辆包括溶剂，表面活性剂和聚合物。 溶剂，表面活性剂和聚合物是不一样的。 溶剂是月桂醇或乳酸月桂酯，表面活性剂选自多元醇，乙氧基化蓖麻油，聚山梨醇酯，酯或饱和醇的醚，和polyoxyethylenepolyoxypropylene嵌段共聚物的酯的选择，所述聚合物选自下组中选择 的聚酯，吡咯烷酮，酯或不饱和醇的醚，和polyoxyethylenepolyoxypropylene嵌段共聚物。

公开(公告)号：EP1658048A2

公开(公告)日：2006-05-24

申请号：EP04781374.6

申请日：2004-08-18

申请人： ALZA CORPORATION

发明人： YAM, Noymi, V. ,  SHIVANAND, Padmaja ,  KIMBEL, Rhea ,  ALLPHIN, Clark, P. ,  WONG, Patrick, S., L.

IPC分类号： A61K9/00

CPC分类号： A61K9/0004

摘要： Compositions and dosage forms for enhanced dispersion of topiramate in a controlled release dosage form released from the dosage form as a dry or substantially dry erodible solid over a prolonged period of time at a stepwise increasing rate of release are described.

公开(公告)号：EP1654030A1

公开(公告)日：2006-05-10

申请号：EP04780069.3

申请日：2004-08-03

申请人： ALZA CORPORATION

发明人： WONG, Patrick, S., L. ,  DADDONA, Peter

IPC分类号： A61M37/00 ,  A61B17/20 ,  A61B10/00

CPC分类号： A61M37/0015 ,  A61B10/0064 ,  A61B17/205 ,  A61B2010/0009 ,  A61M2037/003 ,  A61M2037/0053

摘要： A porous microprojection member (20, 30, 40, 50) for insertion into biological tissue surrounded by interstitial fluid having a wall that includes interior and exterior surfaces, the exterior surface substantially enclosing the interior surface; and a biocompatible coating disposed on the interior surface, the microprojection member being adapted to substantially restrict contact of the coating with the tissue during insertion of the microprojection member into the tissue, the microprojection member having sufficient porosity to allow migration of the interstitial fluid through the wall of the microprojection member.

公开(公告)号：EP1653922A2

公开(公告)日：2006-05-10

申请号：EP04780043.8

申请日：2004-08-03

申请人： ALZA CORPORATION

发明人： REYES, Iran ,  YAM, Noymi V. ,  SHIVANAND, Padmaja ,  LI, Shaoling ,  WONG, Patrick S.L.

IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K31/55

CPC分类号： A61K9/2866 ,  A61K9/0004 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2086 ,  A61K9/209 ,  A61K9/4866 ,  A61K31/35

摘要： Compositions and dosage forms for enhanced dispersion of topiramate in a controlled release dosage form delivered as a dry or substantially dry erodible solid at a uniform rate over a prolonged period of time are described.

公开(公告)号：EP1393724B1

公开(公告)日：2006-04-05

申请号：EP03022248.3

申请日：1997-07-15

申请人： ALZA CORPORATION

发明人： Gale, Robert M. ,  Nelson, Melinda K. ,  Cormier, Michael J.N. ,  Gupta, Suneel K. ,  Campbell, Patricia S.

IPC分类号： A61K31/70 ,  A61K31/135

CPC分类号： A61K9/7084 ,  A61K31/135

公开(公告)号：EP1638468A1

公开(公告)日：2006-03-29

申请号：EP04756456.2

申请日：2004-06-29

申请人： ALZA CORPORATION

发明人： DADDONA, Peter ,  CHAN, Keith, T. ,  DONNER, John, W. ,  AYER, Rupal

IPC分类号： A61B17/20 ,  A61M37/00

CPC分类号： A61K9/0021 ,  A61B17/205 ,  A61M37/0015 ,  A61M2037/0053

摘要： An apparatus (10) and method are provided for selectively applying an agentcontaining liquid coating to extremely tiny skin piercing microprojections (12) . The coating solution is applied to the skin piercing microprojections (12) using a coating technique which selectively coats only predetermined portions the skin piercing microprojections (12) . By the use of various photoresists and hydrophobic coatings, a defined and precise portion of the microprojections and/or the microprojection (12) . arrays can be coated with an agent formulation.

公开(公告)号：EP0959873B1

公开(公告)日：2006-03-01

申请号：EP97952575.5

申请日：1997-12-18

申请人： ALZA CORPORATION

发明人： BRODBECK, Kevin, J. ,  GAYNOR-DUARTE, Ann, T. ,  SHEN, Theodore, T.

IPC分类号： A61K9/00 ,  A61K47/34

CPC分类号： A61K9/0024 ,  A61K9/0019 ,  A61K38/21 ,  A61K38/212 ,  A61K38/27 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34

摘要： Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, compositions having burst indices of 8 or less for systemic applications and systems releasing 10 % or less of the total dose of beneficial agent in the first 24 hours after implantation for local applications. The compositions include a biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.