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51.发明授权PROCESS FOR THE PREPARATION OF CHIRAL BETA AMINO CARBOXAMIDE DERIVATIVES 有权METHOD FOR PRODUCING CHIRALβ-氨基羧酰胺衍生物
公开(公告)号：EP2566843B1
公开(公告)日：2017-03-29
申请号：EP11774543.0
申请日：2011-04-28
发明人： JADAV, Kanaksinh Jesingbhai , BHATT, Rutvij Manharlal , BORKHATARIA, Kamleshkumar Naranbhai , CHITTURI, Trinadha Rao , THENNATI, Rajamannar
IPC分类号： C07C231/02 , C07D487/04
CPC分类号： C07C229/34 , C07C227/14 , C07D487/04
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公开(公告)号：EP3136857A1
公开(公告)日：2017-03-08
申请号：EP15785897.8
申请日：2015-04-29
发明人： PANDEY, Gyanendra , JAVEENA , SINGH, Kaptan , PRASAD, Mohan
IPC分类号： A01N43/42
CPC分类号： C07D487/04 , C07B2200/13
摘要： The present invention provides a crystalline form of baricitinib characterized by an XRPD pattern substantially as depicted in FIG. 1, a process for its preparation, a pharmaceutical composition comprising it, and its use for the treatment of JAK-associated diseases.
摘要翻译： 本发明提供了一种结晶形式的巴里替尼，其制备方法，包含其的药物组合物，以及其用于治疗JAK相关疾病的用途。
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公开(公告)号：EP2656848B1
公开(公告)日：2015-04-08
申请号：EP13165862.7
申请日：2013-04-29
IPC分类号： A61K31/70
CPC分类号： A61K31/7068 , A61K9/0019 , A61K47/02
摘要： A large volume infusion dosage form of gemcitabine, comprising a stable large volume solution of gemcitabine or its pharmaceutically acceptable salt in an aqueous vehicle filled in a large volume infusion container, wherein the solution is ready-to-be-infused.
摘要翻译： 吉西他滨的体积大体积输注剂型，其包含在填充在大容量输注容器中的水性载体中的吉西他滨或其药学上可接受的盐的稳定的大体积溶液，其中所述溶液是可以输注的。
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公开(公告)号：EP1945189A2
公开(公告)日：2008-07-23
申请号：EP06848701.6
申请日：2006-11-03
CPC分类号： A61K9/0065 , A61K9/0004 , A61K9/209 , A61K9/2866 , A61K31/192 , A61K31/198
摘要： The present invention relates to a tablet composed of a core and a coating; said core is formed by two or more layers, wherein at least one of them contains an active agent (3). Wherein one of said layers is formulated as a swellable composition (2), the other one (4) is composed of inert compounds retaining its size at least until the coated tablet is emptied from the stomach. The coating composition is selected from the group comprising water insoluble polymers, ph dependent polymers or mixtures thereof. The active agent is released after rupture of the coating.
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公开(公告)号：EP1871348A2
公开(公告)日：2008-01-02
申请号：EP06780514.3
申请日：2006-03-01
发明人： KHOPADE, Ajay SUN PHARMA ADVANCED RESEARCH CENTRE , GEORGE, Alex SUN PHARMA ADVANCED RESEARCH CENTRE , BHOWMICK, S. B. SUN PHARMA ADVANCED RESEARCH CENT.
CPC分类号： A61K9/5031 , A61K9/0019 , A61K9/1647 , A61K38/31
摘要： A sustained release microsphere composition comprising (i) microspheres comprising (A) a biodegradable polymer which is a homopolymer of lactic acid or a copolymer of lactic acid and glycolic acid having a monomer ratio in the range of about 1:1 to about 3:1, and (B) a therapeutically effective amount of octreotide acetate, and (ii) pharmaceutically acceptable excipients, which when injected, delivers octreotide acetate, for a period of atleast one month.
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公开(公告)号：EP1853228A2
公开(公告)日：2007-11-14
申请号：EP06780513.5
申请日：2006-03-01
发明人： KHOPADE, Ajay, SUN PHARMA ADVANCED RESEARCH CENTRE , GEORGE, Alex, SUN PHARMA ADVANCED RESEARCH CENTRE , BHOWMICK, Subhas Balaram, SUN PHARMA ADV. RES. CTR
IPC分类号： A61K9/16
CPC分类号： A61K9/1647 , A61K9/5031
摘要： A process for the manufacture of free-flowing uniformly sized microspheres for the sustained release of therapeutically active ingredient comprising: a) preparing a first dispersed phase comprising a therapeutically active ingredient, a biodegradable polymer and an organic solvent; b) mixing the first dispersed phase with a aqueous phase to form an emulsion; c) spraying the emulsion into a vessel (20) equipped with organic solvent removal means; d) passing the suspension of microspheres through screens and collecting a fractionated size of the microspheres on the surface of the screens; e) drying the microspheres wherein steps a to e are carried out without manual intervention, in equipment connected in series, substantially unexposed to the environment;
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公开(公告)号：EP1738751A3
公开(公告)日：2007-01-17
申请号：EP06019650.8
申请日：2002-01-11
发明人： Shanghvi, Dilip Shantilal Sun Pharmaceutical , Ganorkar, Kirti Wardhaman Sun Pharmaceutical , Zala, Yashoraj Rupsinh. Sun Pharmaceutical Adv. R. , Dharmadhikari, Nitin B. Sun Pharmaceutical Adv. R. , Khanna, Satish C.
CPC分类号： A61K9/4808 , A61K9/1623 , A61K9/1652 , A61K9/2054 , A61K9/5047 , A61K9/5084 , A61K31/155 , A61K31/64 , A61K45/06 , A61K2300/00
摘要： The present invention provides to a method of administration of two or more therapeutically active agents comprising orally administering to a patient a spaced drug delivery system, wherein the time of release of the two or more therapeutically active agents is designed to provide desired control on the disease condition. The present invention also provides a method of administration of two or more therapeutically active agents comprising orally administering to a patient a spaced drug delivery system at a specified time prior to food intake by the patient. The present invention further provides a spaced drug delivery system that releases two or more antidiabetic agents at different times after oral administration, for the treatment of diabetes mellitus or conditions associated with diabetes mellitus. More particularly, the present invention provides a spaced drug delivery system that immediately releases one or more antidiabetic agents after oral administration of the system, and releases as a pulse one or more antidiabetic agents in a reliable manner at about a predetermined time after oral administration of the system.
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公开(公告)号：EP4364810A3
公开(公告)日：2024-07-24
申请号：EP23219654.3
申请日：2016-11-03
发明人： WEISS, Sidney L.
CPC分类号： A61K47/10 , A61K9/0048 , A61K9/1075 , A61K47/44 , A61K31/425 , A61P27/02 , A61P43/00
摘要： Provided herein include formulations for topical administration, such as ophthalmic formulations, and methods of using such formulations. In some aspects and embodiments the formulations may include a polyoxyl lipid or fatty acid, and/or a polyalkoxylated alcohol and may include nanomicelles. Also include methods of treating or preventing diseases or conditions, such as ocular diseases or conditions.
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公开(公告)号：EP4364751A3
公开(公告)日：2024-06-26
申请号：EP24161843.8
申请日：2019-04-05
发明人： THENNATI, Rajamannar , CHATURVEDI, Nishith , BURADE, Vinod Sampatrao , SHAHI, Pradeep Dinesh , NATARAJAN, Muthukumaran , NAGARAJA, Ravishankara Madavati , ZALAWADIA, Rishit Mansukhlal , PANDYA, Kunal , PATEL, Brijeshkumar , JOSHI, Dhiren Rameshchandra , SONI, Krunal Harishbhai , TIWARI, Abhishek , PATEL, Vipulkumar Shankarbhai
IPC分类号： C07K14/605 , A61K38/26
CPC分类号： C07K14/605 , A61K38/00
摘要： The present disclosure pertains to novel Glucagon like Peptide-1 (GLP-1) (7-37) analogs having an amino acid sequence with Leu or Ile at the C-terminal. The new analogs are potent GLP-1 agonists with reduced adverse effect and improved duration of action. The present disclosure further relates to acylated derivatives of the new analogs which have further improved potency and duration of action and are suitable for oral administration. The analogs of present disclosure may be useful in treatment of diabetes and obesity.
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公开(公告)号：EP4355301A1
公开(公告)日：2024-04-24
申请号：EP22735610.2
申请日：2022-06-13
发明人： HOVANESIAN, John
CPC分类号： A61K38/13 , A61K9/0048 , A61K47/44 , A61K47/32 , A61K47/02 , A61K9/1075 , A61P27/02
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