公开(公告)号：EP1161448A1

公开(公告)日：2001-12-12

申请号：EP00913816.5

申请日：2000-03-09

申请人： Human Genome Sciences, Inc.

发明人： ROSEN, Craig, A. ,  RUBEN, Steven, M. ,  KOMATSOULIS, George

IPC分类号： C07K14/47 ,  C12N5/10 ,  C12N5/16 ,  C12N15/12 ,  C12N15/63 ,  C12N15/64

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/51

摘要： The present invention relates to 49 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

公开(公告)号：EP1144640A2

公开(公告)日：2001-10-17

申请号：EP99934990.5

申请日：1999-07-27

申请人： MICROBIAL TECHNICS LIMITED

发明人： LE PAGE, Richard, William, Falla ,  WELLS, Jeremy, Mark,Actinova Ltd. ,  HANNIFFY, Sean, Bosco ,  HANSBRO, Philip, Michael,CBVTDis. Immun.Microbio

IPC分类号： C12N15/31 ,  C07K14/315 ,  C07K16/12 ,  A61K31/70 ,  A61K39/09 ,  G01N33/53 ,  G01N33/68 ,  C12Q1/68

CPC分类号： C07K14/3156 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00

摘要： Novel proteins from Streptococcus pneumoniae are described, together with nucleic acid sequences encoding them. Their use in vaccines and in screening methods is also described.

摘要翻译： 描述了来自肺炎链球菌的新蛋白质，以及编码它们的核酸序列。 还描述了它们在疫苗和筛选方法中的用途。

公开(公告)号：EP1141276A2

公开(公告)日：2001-10-10

申请号：EP99967346.0

申请日：1999-12-17

申请人： Curagen Corporation

发明人： SHIMKETS, Richard, A.

IPC分类号： C12N15/11 ,  C12N15/12 ,  C12N15/62 ,  C07K14/47 ,  C07K16/18 ,  C12P21/02 ,  C12Q1/68 ,  A61K38/17 ,  A61K48/00 ,  A01K67/027 ,  G01N33/50 ,  G01N33/53

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/51 ,  C07K2319/00

摘要： Disclosed are secreted or membrane-associated human polypeptides, nucleic acids encoding same, as well as antibodies to the polypeptides.

公开(公告)号：EP0954525A4

公开(公告)日：2001-09-12

申请号：EP97926395

申请日：1997-05-01

申请人： SMITHKLINE BEECHAM CORP ,  SMITHKLINE BEECHAM PLC

发明人： WALLIS NICOLA GAIL

IPC分类号： C12N15/09 ,  A61K31/00 ,  A61K31/70 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/00 ,  A61K39/09 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P31/00 ,  A61P31/04 ,  C07K14/315 ,  C07K16/12 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/12 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C07K5/00 ,  A61K39/02 ,  A61K39/085 ,  C07H21/02 ,  C07H21/04 ,  C07K14/00 ,  C12N9/00 ,  C12N15/63

CPC分类号： C12N9/1223 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/51 ,  C07K14/3156

公开(公告)号：EP1124965A1

公开(公告)日：2001-08-22

申请号：EP99951023.3

申请日：1999-10-28

申请人： Aventis Pasteur Limited

发明人： MURDIN, Andrew, David ,  OOMEN, Raymond, Peter ,  DUNN, Pamela Lesley

IPC分类号： C12N15/31 ,  C12N15/62 ,  C07K14/295 ,  C07K16/12 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/569 ,  A61K39/118 ,  A61K48/00

CPC分类号： C07K14/295 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00

摘要： In summary of this disclosure, the present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae, employing a vector, containing a nucleotide sequence encoding a 98 kDa outer membrane protein of a strain of Chlamydia pneumoniae and a promoter to effect expression of the 98kDa outer membrane protein gene in the host. Modifications are possible within the scope of this invention.

摘要翻译： 综上所述，本发明提供了包含DNA，宿主，包括人在内的免疫宿主免受衣原体特异性肺炎衣原体感染引起的疾病的药物，该载体含有核苷酸 编码肺炎衣原体菌株的98kDa外膜蛋白的序列和用于在宿主中表达98kDa外膜蛋白基因的启动子。 在本发明的范围内可以进行修改。

公开(公告)号：EP1124964A1

公开(公告)日：2001-08-22

申请号：EP99951017.5

申请日：1999-10-28

申请人： Aventis Pasteur Limited

发明人： MURDIN, Andrew, David ,  OOMEN, Raymond, Peter ,  DUNN, Pamela Lesley,Apartment 703

IPC分类号： C12N15/31 ,  C12N15/62 ,  C07K14/295 ,  C07K16/12 ,  C12Q1/68 ,  G01N33/543 ,  G01N33/569 ,  A61K39/02 ,  A61K48/00

CPC分类号： C07K14/295 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00 ,  C07K2319/02

摘要： In summary of this disclosure, the present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae, employing a vector, containing a nucleotide sequence encoding a lorf2 protein of a strain of Chlamydia pneumoniae and a promoter to effect expression of the lorf2 gene in the host. Modifications are possible within the scope of this invention.

摘要翻译： 综上所述，本发明提供了包括DNA的核酸的方法，该方法包括免疫宿主（包括人）免于由衣原体菌株特别是肺炎衣原体感染引起的疾病，所述疾病使用含有核苷酸的载体 编码肺炎衣原体菌株的lorf2蛋白的序列和实现宿主中lorf2基因表达的启动子。 在本发明的范围内可以进行修改。

公开(公告)号：EP0846165A4

公开(公告)日：2001-07-18

申请号：EP96919309

申请日：1996-06-07

申请人： UNIV COLORADO STATE RES FOUND ,  HESKA CORP

发明人： WISNEWSKI NANCY ,  GRIEVE ROBERT B ,  FRANK GLENN R ,  TRIPP CYNTHIA ANN

IPC分类号： C12N15/09 ,  A61K35/68 ,  A61K38/00 ,  A61K38/46 ,  A61K38/55 ,  A61K39/00 ,  A61K39/395 ,  A61K48/00 ,  A61P33/00 ,  C07K14/435 ,  C07K16/18 ,  C07K16/40 ,  C12N7/00 ,  C12N9/64 ,  C12N15/57 ,  C12Q1/37 ,  G01N33/50 ,  G01N33/53 ,  G01N33/569 ,  A61K38/48 ,  C12N15/67 ,  C12P21/02

CPC分类号： C12N9/641 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0003 ,  A61K2039/51 ,  C07K14/4354 ,  C07K16/18 ,  C07K16/40 ,  C07K2319/00 ,  C12N9/6402 ,  C12N2799/021 ,  G01N33/5008 ,  G01N33/5091 ,  G01N33/5308 ,  G01N33/56905 ,  G01N2333/4353 ,  G01N2333/95 ,  G01N2333/96402

摘要： The present invention provides for filariid nematode cysteine protease proteins; to filariid nematode cysteine protease nucleic acid molecules, in particular, Dirofilaria immitis L3 larval cysteine protease nucleic acid molecules and Onchocerca volvulus L3 larval cysteine protease nucleic acid molecules; to antibodies raised against such proteins, and to compounds that inhibit filariid nematode cysteine protease activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies and/or inhibitors. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitors, and the use of such compositions to protect an animal from disease caused by parasitic helminths.

公开(公告)号：EP1108046A1

公开(公告)日：2001-06-20

申请号：EP99941654.8

申请日：1999-08-23

申请人： Bavarian Nordic Research Institute A/S

发明人： STÜRZL, Michael ,  CORNALI, Emmanuelle

IPC分类号： C12N15/83 ,  C12N15/62 ,  C12N5/10 ,  C12N7/01 ,  C07K14/47 ,  C07K19/00 ,  C07K16/18 ,  C07K16/42 ,  G01N33/53 ,  C12Q1/68 ,  G01N33/68 ,  A61K38/17 ,  A61K48/00 ,  A61K39/395

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/51 ,  C07K2319/00 ,  C12N2799/027

摘要： The present invention provides an eukaryotic expression vector comprising the Guanylate Binding Protein 1 (GBP-1) gene or parts thereof. The introduction of said vector comprising said gene or parts thereof in sense or antinsense orientation into cells can be used to induce phenotypical changes of said cells and can, thus, be used for modulation of cell differentiation. Additionally, the present invention provides said vector for the treatment of cancer, sarcoma, lymphoma, hemangioma, artherosclerosis or restenosis, but also the treatment of inflammatory diseases like chronic ulcerative diseases, psoriasis, insect bites, freezing or burning injuries, wound healing or Morbus Crohn. Furthermore, the present invention provides, inter alia, a method for determination of the stage of cellular differentiation by using GBP-1 gene expression as a marker.

公开(公告)号：EP1105489A1

公开(公告)日：2001-06-13

申请号：EP99939279.8

申请日：1999-08-19

申请人： Aventis Pasteur Limited

发明人： MURDIN, Andrew, D. ,  DUNN, Pamela L. ,  OOMEN, Raymond, P.

IPC分类号： C12N15/31 ,  C07K14/295 ,  A61K48/00 ,  A61K31/70

CPC分类号： C07K14/295 ,  A61K39/00 ,  A61K2039/51

摘要： An isolated and purified nucleic acid molecule encoding a POMP91A protein of a strain of Chlamydia, is useful for nucleic acid immunization of a host, including a human host, against disease caused by infection by a strain of Chlamdia, particularly C. pneumoniae.

公开(公告)号：EP1105157A1

公开(公告)日：2001-06-13

申请号：EP99940951.9

申请日：1999-08-10

申请人： MERCK & CO., INC.

发明人： LOWE, Robert, S. ,  JANSEN, Kathrin, U. ,  JOYCE, Joseph, G. ,  MCCLEMENTS, William, L. ,  COOK, James, C., III ,  LING, Jessica, Ching-Yee ,  NEEPER, Michael, P.

IPC分类号： A61K39/12 ,  A61K48/00 ,  C07H21/02 ,  C07H21/04 ,  C12N5/10 ,  C12N7/01 ,  C12N7/04 ,  C12N15/37 ,  C12N15/86

CPC分类号： C07K14/005 ,  A61K2039/51 ,  C07K2319/00 ,  C12N15/86 ,  C12N2710/20022 ,  C12N2710/20023 ,  C12N2830/002 ,  C12N2830/702

摘要： Human Papillomavirus virus like particles (VLPs) have been constructed so that they contain a modified L2 protein. The L2 protein has been minimized and is fused to a second protein or peptide. The fused protein is incorporated into the VLP and the VLP can deliver the protein to a cell. The modified VLPs can be used to increase the breadth of immune response in vaccine preparations or to deliver other proteins of interest.