公开(公告)号：EP1677677A1

公开(公告)日：2006-07-12

申请号：EP04789495.1

申请日：2004-09-30

申请人： E-Z-EM, Inc.

发明人： WILLIAMS, Archie, B., III

IPC分类号： A61B5/055

CPC分类号： A61K49/0404

摘要： The present invention relates to contrast media having a low concentration of contrast agent (active ingredient) and/or low Hounsfield value for use in medical or diagnostic procedures, or for therapeutic use. In one alternative embodiment, the contrast media are comprised of a contrast agent, alone or in combination with a stabilizing agent or osmotic agent. The present invention is directed to a contrast media having a Hounsfield value less than 250. In another embodiment, the contrast media comprises a contrast agent, such as a less than 2% w/v barium-based compound. In another embodiment, the present invention also relates to formulations and methods for distending and imaging an anatomic segment of an individual.

公开(公告)号：EP0996469B1

公开(公告)日：2003-08-20

申请号：EP98930870.5

申请日：1998-06-16

申请人： Amersham Health AS

发明人： HENRICHS, Paul, Mark ,  ERIKSEN, Morten ,  RONGVED, Pal ,  GUNTHER, Wolfgang, Hans, Heinrich ,  SNOW, Robert, Allen ,  HOLLISTER, Kenneth, Robert ,  MCINTIRE, Gregory, Lynn

IPC分类号： A61K49/00

CPC分类号： A61K41/00 ,  A61B6/508 ,  A61K49/00 ,  A61K49/0002 ,  A61K49/0034 ,  A61K49/0078 ,  A61K49/0084 ,  A61K49/0091 ,  A61K49/0404 ,  A61K49/0438 ,  A61K49/0466 ,  Y10S977/949

摘要： The invention relates to a method of generating an image of an animate human or non-human animal body or part thereof. The method comprises administering to said body a physiologically tolerable contrast agent comprising a radiation absorbing component and/or a pressure inducing component, exposing said body to radiation, detecting pressure waves generated in said body by said radiation and generating an optoacoustic image therefrom of at least a part of said body containing the administered contrast agent.

公开(公告)号：EP1008356A1

公开(公告)日：2000-06-14

申请号：EP98905737.7

申请日：1998-03-03

申请人： Kowa Co., Ltd.

发明人： INAGI, Toshio ,  SHINKAWA, Yasuhiro ,  OKANO, Teruo

IPC分类号： A61K49/04

CPC分类号： B82Y5/00 ,  A61K49/0404 ,  A61K49/0428 ,  A61K49/0476

摘要： The invention relates to an X-ray contrast medium comprising an X-ray contrast substance coated with a polymer which adheres to the surface of a gastrointestinal mucosa under acid conditions and separates from the surface of the gastrointestinal mucosa under neutral or alkaline conditions. The X-ray contrast medium has excellent adhesiveness to a digestive tract, so that its doses and concentration can be reduced.

摘要翻译： 本发明涉及一种X射线造影剂，其包含涂布有聚合物的X射线造影剂，所述聚合物在酸性条件下粘附于胃肠粘膜表面并在中性或碱性条件下与胃肠粘膜表面分离。 X射线造影剂对消化道具有优异的粘附性，因此其剂量和浓度可以降低。

公开(公告)号：EP0996469A1

公开(公告)日：2000-05-03

申请号：EP98930870.5

申请日：1998-06-16

申请人： NYCOMED IMAGING AS ,  Towler, Philip Dean

发明人： HENRICHS, Paul, Mark ,  ERIKSEN, Marten ,  RONGVED, P l ,  GUNTHER, Wolfgang, Hans, Heinrich ,  SNOW, Robert, Allen ,  HOLLISTER, Kenneth, Robert ,  MCINTIRE, Gregory, Lynn

IPC分类号： A61K49/00

CPC分类号： A61K41/00 ,  A61B6/508 ,  A61K49/00 ,  A61K49/0002 ,  A61K49/0034 ,  A61K49/0078 ,  A61K49/0084 ,  A61K49/0091 ,  A61K49/0404 ,  A61K49/0438 ,  A61K49/0466 ,  Y10S977/949

摘要： The invention relates to a method of generating an image of an animate human or non-human animal body or part thereof. The method comprises administering to said body a physiologically tolerable contrast agent comprising a radiation absorbing component and/or a pressure inducing component, exposing said body to radiation, detecting pressure waves generated in said body by said radiation and generating an optoacoustic image therefrom of at least a part of said body containing the administered contrast agent.

公开(公告)号：EP0756873A3

公开(公告)日：1998-05-06

申请号：EP96500115

申请日：1996-08-02

申请人： CANTABRIA IND FARMACEUTICA SA ,  GALLO DE LLANOS S L

发明人： GALLO MOLINA RAMON

IPC分类号： A61K49/04

CPC分类号： A61K49/0404

摘要： A procedure for obtaining extemporaneous and direct use radiological contrast formulations for gastrointestinal exploration, comprising a radio-opaque contrast based on a micronized barium sulfate and a substance, i.e. sucralfate, which permits the selective adherence of the contrast to the injured zone and is obtained by interposing the barium sulfate in the sucralfate paste in an acid medium.
These formulations are appropriate for being administered orally or rectally.

公开(公告)号：EP0614669A3

公开(公告)日：1995-06-07

申请号：EP94200620.6

申请日：1994-03-10

申请人： NYCOMED IMAGING AS

发明人： Illig, Carl R., c/o Sterling Winthrop Inc. ,  Douty, Brent D., c/o Sterling Winthrop Inc.

IPC分类号： A61K49/04

CPC分类号： A61K49/0404 ,  A61K49/04 ,  A61K49/0409 ,  A61K49/0433 ,  Y10S514/941 ,  Y10S514/942

摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the GI tract comprising a polymeric material capable of forming a coating on the GI tract, said polymeric material having atoms containing polarizable electrons thereon, in combination with a divalent cation; and an x-ray contrast producing agent of the formula

wherein
Z = H, halo, C 1 -C 20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R = C 1 -C 25 alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy, (CR 1 R 2 ) p - (CR 3 = CR 4 ) mQ , or (CR 1 R 2 )p - C ≡ C - Q; Ri, R 2 , R 3 and R 4 are independently lower-alkyl, optionally substituted with halo; x is 1-3 y is 1-4; n is 1-5; m is 1-15; p is 1-10; and Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl; in a pharmaceutically acceptable carrier and a method of its use in diagnostic radiology of the GI tract.

公开(公告)号：EP0631503A1

公开(公告)日：1995-01-04

申请号：EP92913717.0

申请日：1992-04-24

申请人： KORMAN, Louis Y.

发明人： KORMAN, Louis Y.

IPC分类号： A61K31 ,  A61K38 ,  A61K49 ,  A61K51 ,  A61P1 ,  A61P23 ,  A61P25

CPC分类号： A61K49/0409 ,  A61K31/4465 ,  A61K31/4468 ,  A61K31/5513 ,  A61K31/5517 ,  A61K38/2278 ,  A61K49/0404 ,  A61K51/04 ,  A61K2300/00

摘要： A method of inducing a temporary substantial paralysis of an area of interest in a patient undergoing a medical procedure is provided. The method involves administering a therapeutically effective amount of vasoactive intestinal peptide (VIP) admixed with a pharmaceutically acceptable carrier to a patient undergoing an endoscopy or other medical procedure.

公开(公告)号：EP0613689A3

公开(公告)日：1994-10-19

申请号：EP94200486.2

申请日：1994-02-24

申请人： NYCOMED IMAGING AS

发明人： Caulfield, Thomas J., c/o STERLING WINTHROP INC. ,  Illig, Carl R., c/o STERLING WINTHROP INC.

IPC分类号： A61K49/04

CPC分类号： A61K49/0404 ,  A61K49/0409 ,  A61K49/0461

摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract , in combination with a divalent cation and an x-ray contrast producing agent of the formula

or a pharmaceutically acceptable salt thereof,
and methods for their use in diagnostic radiology of the gastrointestinal tract wherein
Z = H, halo, C 1 -C 20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R 1 and R 2 are independently C l -C 25 alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxycarbonyloxy; n is 1-5; y is 1-4; and x is 1 or 2
in a pharmaceutically acceptable carrier.

摘要翻译： X射线对比度 口服或直肠给药。 包括：（a）能够在胃肠道（GI）道上形成涂层并具有原子的聚合物（I） 与二价阳离子组合的极化电子（sic）; 和（b）式（II）的X射线造影剂， 盐形式：Z = H，卤素，低级烷氧基，CN或1-20C烷基或环烷基选择。 substd。 卤代或低级卤代烷基; R1和R2 = H; 1-25C烷基，环烷基或低级卤代烷基。 substd。 低级氟烷基，低级烷氧基，OH，COOH，低级烷氧基羰基或低级烷氧基羰基氧基; 或乙酰基选择。 substd。 低级氟烷基，芳基，低级烷氧基，OH，低级烷氧基羰基或低级烷氧基羰基氧基; n = 1-4; y = 1-4; x = 1或2。

公开(公告)号：EP0609586A2

公开(公告)日：1994-08-10

申请号：EP93203674.2

申请日：1993-12-24

申请人： NYCOMED IMAGING AS

发明人： Illig, Carl, c/o Sterling Winthrop Inc. ,  Cooper, Eugene R., c/o Sterling Winthrop Inc. ,  Toner, John L., c/o Sterling Winthrop Inc. ,  Upson, Donald, c/o Sterling Winthrop Inc. ,  Douty, Brent D., c/o Sterling Winthrop Inc. ,  Caulfield, Thomas J., c/o Sterling Winthrop Inc. ,  Bacon, Edward R., c/o Sterling Winthrop Inc. ,  Estep, Kimberley G., c/o Sterling Winthrop Inc. ,  Josef, Kurt A., c/o Sterling Winthrop Inc. ,  Robinson, Shaughnessy, c/o Sterling Winthrop Inc. ,  Spara, Paul P., c/o Sterling Winthrop Inc.

IPC分类号： A61K49/04 ,  C07C22/04

CPC分类号： A61K49/0404 ,  A61K49/04 ,  A61K49/0409 ,  A61K49/0433 ,  Y10S514/941 ,  Y10S514/942

摘要： Disclosed are contrast agents of the formula

or pharmaceuticaoly acceptable salts thereof,
contained in aqueous compositions and methods for their use in diagnostic radiology of the gastrointestinal tract wherein

Z = H, halo, C₁-C₂₀ alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;
R = C₁-C₂₅ alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy, (CR₁R₂) p - (CR₃ = CR₄) m Q, or (CR₁R₂) p - C ≡ C - Q;
R₁, R₂, R₃ and R₄ are independently lower-alkyl, optionally substituted with halo;
x is 1-4;
n is 1-5;
m is 1-15;
p is 1-10; and
Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl.

摘要翻译： 口服或直肠给药 X射线对比组合 用于胃肠道的可视化包括0.001-75w / v％的式（I）的造影剂（或（I）的盐），其形式为水溶液。 分散体含有0.01-15w / v％的选自三甲基溴化铵，月桂基硫酸钠，十七烷基硫酸钠，烷基苯磺酸，丁基萘磺酸钠和磺基琥珀酸钠和两性离子表面活性剂中的至少一种表面活性剂。 在（I）中，Z = H，卤素，1-20C烷基，环烷基，低级烷氧基或CN，其中烷基和环烷基gps。 是选择。 substd。 卤代或卤代低级烷基; R = Me，Et，Pr，9-25C烷基，卤代低级烷基， substd。 （CR 1 R 2）p（CR 3 = CR 4）m Q或（CR 1 R 2）p C = C 1 -C 6烷基，C 1 -C 6烷基羰基或低级烷氧基羰氧基 ; （原文如此）; R1-R4 =低级烷基选择。 substd。 被晕 x = 1-4; n = 1-5; m = 1-15; p = 1-10; Q = H，低级烷基，低级烯基，低级炔基，低级亚烷基，芳基或芳基 - 低级烷基。

公开(公告)号：EP0488024A1

公开(公告)日：1992-06-03

申请号：EP91119720.0

申请日：1991-11-19

申请人： Klein, Hans-Martin, Dr. med.

发明人： Klein, Hans-Martin, Dr. med.

IPC分类号： A61K49/04

CPC分类号： A61K49/0404

摘要： Als Hilfsmittel zur Untersuchung des Dünndarmes wird eine Kapsel (1) mit einer Füllung vorgeschlagen, die bei Kontakt mit H₂O Gas freisetzt. Die Kapsel (1) ist mit einer säurefesten und magensaftresistenten Beschichtung (2) versehen. Die Beschichtung (2) gibt die Füllung (3) erst frei, nachdem die Kapsel (1) den Magen passiert hat und in den Dünndarm gelangt ist.

摘要翻译： 助剂是具有填充物的胶囊（1），其在与H 2 O接触时释放气体。 胶囊（1）具有耐酸和胃液的涂层（2）。 涂层（2）仅在胶囊（1）已经通过胃并到达小肠之后释放填充物（3）。