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    Effervescent formulations comprising a phosphonate and methods for their preparation
    53.
    发明公开
    Effervescent formulations comprising a phosphonate and methods for their preparation 有权
    Efferveszenzformulierungen mit einem Phosphonat und Herstellungsverfahrendafür

    公开(公告)号：EP2283823A1

    公开(公告)日：2011-02-16

    申请号：EP09009791.6

    申请日：2009-07-29

    申请人： Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. ,  Tseti, Ioulia

    发明人： Tseti, Ioulia

    IPC分类号： A61K9/20 ,  A61K9/16

    CPC分类号： A61K9/0007 ,  A61K9/1611 ,  A61K9/2009

    摘要： The invention provides an effervescent pharmaceutical composition comprising a biphosphonate compound or its pharmaceutically acceptable salt, a carbonate source, an acid source, a divalent metal salt as humidity moderator and a divalent cation scavenger, wherein the molar ratio of divalent cation scavenger to humidity moderator is at least 0.8/1. This composition makes the production of effervescent formulations comprising biphosphonate compounds easier, since less stringent controls or even no control of environmental humidity conditions have to be carried out during the production of the product. Moreover, the final product is protected against the negative impact of humidity, which may induce disintegration during the shelf-life of the product.

    摘要翻译： 本发明提供了包含二膦酸盐化合物或其药学上可接受的盐，碳酸盐源，酸源，作为调湿剂的二价金属盐和二价阳离子清除剂的泡腾药物组合物，其中二价阳离子清除剂与湿度调节剂的摩尔比为 至少0.8 / 1。 该组合物使得包含双膦酸酯化合物的泡腾制剂的生产更容易，因为在产品生产期间必须进行不太严格的控制或甚至不控制环境湿度条件。 此外，最终产品可以防止潮湿的负面影响，这可能在产品的保质期内引起分解。

    COMPRESSED PHARMACEUTICAL COMPOSITIONS COMPRISING PEG AND ELECTROLYTES
    54.
    发明授权
    COMPRESSED PHARMACEUTICAL COMPOSITIONS COMPRISING PEG AND ELECTROLYTES 有权
    与PEG和电解质的压制药物组合物

    公开(公告)号：EP1742645B1

    公开(公告)日：2011-01-26

    申请号：EP05735983.8

    申请日：2005-04-25

    申请人： Norgine BV

    发明人： Barras, Norman ,  Cox, Ian

    IPC分类号： A61K31/765 ,  A61P1/10 ,  A61K9/20 ,  A61K33/14

    CPC分类号： A61K9/2022 ,  A61K9/0007 ,  A61K31/77

    摘要： The invention provides a compressed pharmaceutical composition comprising polyethylene glycol of molecular weight from 2000 to 4500, wherein the polyethylene glycol makes up from 80 to 99.5% by weight of the composition, one or more electrolytes for the treatment of constipation, faecal impaction, faecal retention, intestinal gas and cramping, or flatulence; or for orthostatic lavage, colon evacuation or colon cleansing. It has been found, surprisingly, that a compressed pharmaceutical composition comprising PEG for example a solid tablet, is significantly more palatable than previously proposed compositions and is effective when administered. The compressed pharmaceutical composition of the invention comprising polyethylene glycol has been found to have a more agreeable taste and a more agreeable mouthfeel than previously proposed liquid or dry powder or granular compositions.