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    Mammalian Tissue Factor obtained from plants and applications of the same
    54.
    发明授权
    Mammalian Tissue Factor obtained from plants and applications of the same 有权
    从植物的哺乳动物组织特异性因子及其应用获得

    公开(公告)号：EP1774001B1

    公开(公告)日：2012-08-22

    申请号：EP05762794.5

    申请日：2005-06-22

    申请人： Altor BioScience Corporation

    发明人： NEGROUK, Valentin ,  WONG, Hing, C. ,  TAYLOR, Dean ,  HAN, Kai-ping

    IPC分类号： A61K38/36 ,  C07K14/745

    CPC分类号： C07K14/70596 ,  C12N15/8257

    摘要： The instant invention provides plant expression vectors comprising a first promoter operable in a plant, an expressible nucleic acid sequence encoding a mammalian tissue factor protein or functional fragment thereof, wherein the nucleic acid sequence is peparatively associated with the promoter, and a termination sequence operatively associated with the nucleic acid sequence. The invention further provides methods of making the tissue factor protein, or functional fragment thereof, using the claimed vectors and plants, and methods of treating or preventing blood loss, of promoting wound healing, promoting angiogenesis, or promoting vascular remodeling in a subject by administering the tissue factor proteins to a subject.

    Mucosal or enteral administration of biologically active macromolecules
    55.
    发明公开
    Mucosal or enteral administration of biologically active macromolecules 审中-公开
    生物活性大分子的粘膜或肠内给药

    公开(公告)号：EP2484768A2

    公开(公告)日：2012-08-08

    申请号：EP11175328.1

    申请日：2006-07-18

    申请人： Protalix Ltd.

    发明人： Shaaltiel, Yoseph ,  Almon, Einat

    IPC分类号： C12N15/82

    CPC分类号： C12N15/8257 ,  C12N15/8258

    摘要： A unit dosage form for delivery of a biologically active recombinant biomolecule to a tissue of a subject, the unit dosage form comprising, a therapeutically effective amount of isolated plant cells of a plant cell culture, said isolated plant cells expressing the recombinant biomolecule.

    摘要翻译： 用于将生物活性重组生物分子递送至受试者组织的单位剂型，所述单位剂型包含治疗有效量的植物细胞培养物的分离的植物细胞，所述分离的植物细胞表达重组生物分子。

    GENERATION OF HIGH POLYHYDROXYBUTRATE PRODUCING OILSEEDS
    56.
    发明公开
    GENERATION OF HIGH POLYHYDROXYBUTRATE PRODUCING OILSEEDS 审中-公开
    高聚羟基丁酸酯生产油脂的生成

    公开(公告)号：EP2477477A1

    公开(公告)日：2012-07-25

    申请号：EP10757680.3

    申请日：2010-09-15

    申请人： METABOLIX, INC. ,  Donald Danforth Plant Science Center

    发明人： PATTERSON, Nii ,  TANG, Jihong ,  CAHOON, Edgar, Benjamin ,  JAWORSKI, Jan, G. ,  YANG, Wenyu ,  PEOPLES, Oliver, P. ,  SNELL, Kristi, D.

    IPC分类号： A01H1/02 ,  C12N15/82

    CPC分类号： C12N15/8214 ,  C12N15/8257

    摘要： Transgenic oilseed plants, plant material, plant cells, and genetic constructs for synthesis of polyhydroxyalkanoates ("PHA") are provided. In a preferred embodiment, the transgenic oilseed plants synthesize (poly)3- hydroxybutyrate ("PHB") in the seed. Genes utilized include phaA,phaB, phaC, all of which are known in the art. The genes can be introduced in the plant, plant tissue, or plant cell using conventional plant molecular biology techniques.

    摘要翻译： 提供了用于合成聚羟基链烷酸酯（“PHA”）的转基因油籽植物，植物材料，植物细胞和遗传构建体。 在一个优选的实施方案中，转基因油籽植物在种子中合成（聚）3-羟基丁酸（“PHB”）。 使用的基因包括phaA，phaB，phaC，所有这些都是本领域已知的。 可以使用常规植物分子生物学技术将基因引入植物，植物组织或植物细胞中。

    Method for producing mullerian inhibitor substance in plants
    57.
    发明公开
    Method for producing mullerian inhibitor substance in plants 审中-公开
    Pflanzen的Verfahren zur Produktion vonMüllerian-Inhibitor-Substanz

    公开(公告)号：EP2468872A1

    公开(公告)日：2012-06-27

    申请号：EP10016035.7

    申请日：2010-12-23

    申请人： Philip Morris Products S.A.

    发明人： The designation of the inventor has not yet been filed

    IPC分类号： C12N15/82

    CPC分类号： C07K14/495 ,  C12N15/8257

    摘要： The present invention provides, in one aspect, a method for producing Mullerian Inhibitor Substance in a plant comprising incubating or growing a plant into which has been introduced or infiltrated a nucleic acid construct comprising, consisting or consisting essentially of a nucleic acid sequence encoding a Mullerian Inhibitor Substance fusion protein that comprises a fusion protein partner that induces the formation of a protein body in a plant, preferably, wherein the step of introducing or infiltrating the plant is performed prior to the incubating or growing step.

    摘要翻译： 在一个方面，本发明提供了一种在植物中产生穆勒抑制剂物质的方法，其包括将植物培养或生长至其已被引入或渗入其中的核酸构建体，所述核酸构建体包含基本上由编码穆勒（Muller） 抑制剂物质融合蛋白，其包含在植物中诱导蛋白质体形成的融合蛋白质伴侣，优选地，其中引入或渗透植物的步骤在孵育或生长步骤之前进行。

    Method for expressing desxoyribonuclease in plants
    58.
    发明公开
    Method for expressing desxoyribonuclease in plants 审中-公开
    Verfahren zur表达von脱氧核糖核酸在Pflanzen

    公开(公告)号：EP2468870A1

    公开(公告)日：2012-06-27

    申请号：EP10016033.2

    申请日：2010-12-23

    申请人： Philip Morris Products S.A.

    发明人： The designation of the inventor has not yet been filed

    IPC分类号： C12N15/82

    CPC分类号： C12N9/22 ,  C07K14/415 ,  C12N15/8243 ,  C12N15/8251 ,  C12N15/8257

    摘要： The present invention provides, in one aspect, to a method for expressing DNase in a plant comprising growing a plant that has been transformed with a nucleic acid construct comprising a nucleic acid sequence encoding DNase under the control of a regulatory nucleotide sequence that regulates the transcription of said nucleic acid sequence in said plant.

    摘要翻译： 在一个方面，本发明提供了在植物中表达DNase的方法，其包括用在包含调节转录调控核苷酸序列的编码DNA酶的核酸序列的核酸构建体上转化的植物 的所述核酸序列。