摘要:
A method for monitoring changes in the level of an osmotically active component, such as for instance glucose, or in healthy humans, such as athletes for monitoring the level of lactic acid in the muscles is described. The key feature of the method is that the osmotic movement back and forth over a membrane is used to activate a sensing device, whereby the physical changes that take place in the fluid may be recorded by a receiver situated outside the body. A device for carrying out said method is likewise described.
摘要:
In this invention, a measurement of cell permeability is determined by obtaining a measure of the volume of fluid which crosses a sample cell membrane in response to an altered environment. A lytic agent may be used to drive fluid across the cell membranes and thereby cause a change in cell volume. An alteration in osmolality of a sample suspension is preferred, in which the sample suspension is subjected to a continuous osmotic gradient.
摘要:
An osmometric device is disclosed for determining the content of an analyte made up of one or several substances in a solution of mixed substances. The device consists of an osmotic cell (A) provided with a manometric device and mounted downstream of an osmotic cell (B). Both cells are separated by an inner membrane (a). The upstream cell (B) in turn has a second membrane (b). The second membrane (b) forms a part of a wall of a duct. The duct communicates with a supply line through which a solution suitable for setting the working pressure or the solution of mixed substances are selectively supplied. The inner membrane (a) is impervious to the analyte and permeable to the solvent, and the outer membrane (b) is permeable to the analyte and impervious to the remaining substances that make up the mixture of substances. The same non-permeating osmotic medium with the same osmolarity is contained in both osmotic cells in the initial or regenerated base state. This device allows an analyte content of a solution of mixed substances to be more quickly determined than it was possible in the state-of-the-art.
摘要:
A method and an apparatus for determining the molecular weight by osmometry in which a fluid circuit is used having two pressure measurement zones (26, 30). One (26) of which is responsive only to viscosity effects and the other (30) being responsive to both viscosity and osmotic effects. The osmotic effects are caused by cross-linked polymeric material (36) capable of expanding and contracting in response to the presence of a solvent (14) and solute, respectively, thereby changing the effective radius of the zone and, thereby, the pressure.
摘要:
Bei einem Verfahren zur Bestimmung des Gehaltes von in einem Lösungsmittel gelösten Stoffen mittels eines Osmometer, bestehend aus einem Zweikammersystem mit einer ersten Kammer mit einer osmotischen Zelle und einer zweiten Kammer für die Meßlösung, wird zur Verkürzung der Meßzeit und zur Verbesserung der Trennung permeierender Komponenten während der Messung des Gehaltes der Stoffe in der Meßlösung der Druck in der osmotischen Zelle bei einer vorhandenen inkompressiblen Membrananordnung konstant gehalten, wobei mit einer Druckmeßeinrichtung in der zweiten Kammer nach dem Austausch eines Lösungsmittels, eine Bezugs- oder Kalibrierlösung durch eine Meßlösung ein den Konzentrationen der nichtpermeierenden und permeierenden Stoffe bzw. ein den Flüssen der permeierenden Stoffe zwischen der osmotischen Zelle und der zweiten Kammer entsprechender Druckverlauf gemessen und durch Analyse des Kurvenverlaufes der Gehalt der nichtpermeierenden und permeierenden Stoffe in der Meßlösung ermittelt wird. In einer Abwandlung ist vorgesehen, daß das Volumen der ersten Kammer, in der die osmotische ZeIle angeordnet ist, mittels einer Einrichtung in Abhängigkeit von dem ermittelten zeitlichen Druckverlauf verändert wird, bis dieser Wert den Wert 0 annimmt. Auch hierbei wird die aufgezeichnete Kurve ausgewertet.
摘要:
A sample receiving chip comprising a substrate that receives an aliquot volume of a sample fluid and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region. The energy imparted into the sample fluid is transduced by the sample region to produce an output signal that indicates energy properties of the sample fluid. The sample receiving chip also includes a channel formed in the substrate, the channel configured to collect the aliquot volume of a sample fluid and transfer the aliquot volume of sample fluid to the sample region.
摘要:
A method for producing coke is provided which method comprising measuring the permeation distance, which is a thermal plasticity of coal, with respect to a coal or coals to be added to a coking coal blend that have a logarithmic value of Gieseler maximum fluidity, logMF, of not less than 3.0,based on a weighted-average value of the measured permeation distance(s), determining the blend ratio of the coal(s) having a logarithmic value of Gieseler maximum fluidity, logMF, of not less than 3.0, and carbonizing coals that have been blended according to the determined blend ratio.
摘要:
Osmolarity measurement of a sample fluid, such as tear film, is achieved by depositing an aliquot-sized sample on a sample receiving substrate. The sample fluid is placed on a sample region of the substrate. Energy is imparted to the sample fluid and energy properties of the fluid can be detected to produce a sample fluid reading that indicates osmolarity of the sample fluid. An aliquot-sized volume can comprise, for example, a volume of no more than 20 microliters (µL) . The aliquot-sized sample volume can be quickly and easily obtained, even from dry eye sufferers. The imparted energy can comprise electrical, optical or thermal energy. In the case of electrical energy, the energy property of the sample fluid can comprise electrical conductivity. In the case of optical energy, the energy property can comprise fluorescence. In the case of thermal energy, the measured property can be the freezing point of the sample fluid. The substrate can be packaged into a chip, such as by using semiconductor fabrication techniques. An ex vivo osmolarity sensor system that uses the chip can detect energy from the sample region and can provide an accurate osmolarity measurement without user intervention.