公开(公告)号：EP2277051A1

公开(公告)日：2011-01-26

申请号：EP09741736.4

申请日：2009-04-28

申请人： Otto-von-Guericke Universität Magdeburg Medizinische Fakultät

发明人： HOFFMANN, Werner

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N2800/34 ,  G01N2800/345

摘要： The invention relates to methods for detecting diseases of the excretory urinary tracts. The aim of the invention is to provide a method for detecting the existence of diseases of the excretory urinary tracts, which can be carried out non-invasively, thus allowing first indications of disease, e.g. in relation to the existence of renal calculi and/or inflammation (e.g. after urinary tract infections) of the excretory urinary tracts, to be rapidly and cost-effectively detected, in order to resolve e.g. microhaematuria caused by inflammation rapidly and cost-effectively. To achieve this, the presence or concentration of TFF-peptides is determined in the urine.

公开(公告)号：EP1934598B1

公开(公告)日：2010-09-22

申请号：EP06794763.0

申请日：2006-10-13

申请人： Petyaev, Ivan Mikhailovich

发明人： AKHATOVNA ZIGANGIROVA, Nailya ,  PETYAEV, Ivan Mikhailovich

IPC分类号： G01N33/50 ,  C12N5/10 ,  C12N15/11 ,  C12Q1/18 ,  C12Q1/68 ,  A61K39/02 ,  A61K39/118 ,  A61K31/7048

CPC分类号： C12Q1/689 ,  C12Q2600/158 ,  G01N33/56927 ,  G01N33/56933 ,  G01N2800/34 ,  G01N2800/36 ,  G01N2800/367

公开(公告)号：EP2216023A1

公开(公告)日：2010-08-11

申请号：EP08851020.1

申请日：2008-11-14

申请人： Takeda Pharmaceutical Company Limited

发明人： MATSUMOTO, Takahiro ,  NAGAMIYA, Hiroyuki ,  MAEZAKI, Hironobu ,  KUSUMOTO, Tomokazu ,  YOSHIKAWA, Kyoko ,  FURUKAWA, Hideki ,  KAMO, Izumi

IPC分类号： A61K31/4545 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/00 ,  A61P1/00 ,  A61P3/04 ,  A61P13/02 ,  A61P13/10 ,  A61P43/00 ,  C07D471/04 ,  G01N33/15 ,  G01N33/50

CPC分类号： A61K31/5377 ,  A61K31/4545 ,  A61K31/55 ,  C07D471/04 ,  G01N33/5088 ,  G01N33/6893 ,  G01N2800/34

摘要： Provided are a condensed pyridine derivative having a serotonin 5-HT 2C receptor activation action, a prophylactic or therapeutic agent for a lower urinary tract symptom, obesity and/or organ prolapse and the like containing the condensed pyridine derivative, a screening method for a substance that increases leak point pressure upon a rise in the intravesical pressure or a prophylactic or therapeutic drug for stress urinary incontinence, a prophylactic or therapeutic drug for cystoceles or enteroceles, containing a substance that activates serotonin 5-HT 2C receptor, and a method of screening for a therapeutic drug for cystoceles or enteroceles, including increasing an intravesical pressure after bilateral transection of the hypogastric nerve and pudendal nerve of an animal, and measuring a closure response in the urethra, the rectum or the vagina observed at that time. A serotonin 5-HT 2C receptor activator containing a compound represented by the formula:

wherein each symbol is as defined in the specification, or a salt thereof.

摘要翻译： 提供具有5-羟色胺5-HT 2C受体激活作用的缩合吡啶衍生物，含有缩合吡啶衍生物的下尿路症状，肥胖症和/或器官脱垂等的预防或治疗剂，物质的筛选方法 在膀胱压力上升时的泄漏点压力或压力性尿失禁的预防或治疗药物，包含激活5-羟色胺5-HT 2C受体的物质的用于膀胱或肠的预防或治疗药物的筛选压力和筛选方法 用于治疗用于膀胱或肠道的治疗药物，包括在双侧横断动物的下腹神经和阴部神经之后增加膀胱内压力，并测量当时观察到的尿道，直肠或阴道中的闭合反应。 含有下式表示的化合物的5-羟色胺5-HT 2C受体活化剂或其盐，其中每个符号如说明书中所定义。

公开(公告)号：EP2074429A1

公开(公告)日：2009-07-01

申请号：EP07818669.9

申请日：2007-10-04

申请人： Bayer Schering Pharma AG

发明人： GOLZ, Stefan ,  SUMMER, Holger ,  GEERTS, Andreas ,  BRÜGGEMEIER, Ulf ,  ALBRECHT-KÜPPER, Barbara ,  KLEIN, Martina ,  STEPPAN, Sonja ,  ELLINGHAUS, Peter ,  D'URSO, Donatella ,  SEEWALD, Michael ,  MILTING, Hendrik

IPC分类号： G01N33/68 ,  C12Q1/68

CPC分类号： G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2800/06 ,  G01N2800/12 ,  G01N2800/22 ,  G01N2800/28 ,  G01N2800/32 ,  G01N2800/34

摘要： The invention provides CTGF which is associated with the cardiovascular diseases and hematological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases and hematological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of CTGF as well as pharmaceutical compositions comprising such compounds. The invention also provides CTGF as a biomarker for diseases as cardiovascular diseases and hematological diseases

公开(公告)号：EP1934598A2

公开(公告)日：2008-06-25

申请号：EP06794763.0

申请日：2006-10-13

申请人： Petyaev, Ivan Mikhailovich

发明人： AKHATOVNA ZIGANGIROVA, Nailya

IPC分类号： G01N33/50 ,  C12N5/10 ,  C12N15/11 ,  C12Q1/18 ,  C12Q1/68 ,  A61K39/02 ,  A61K39/118 ,  A61K31/7048

CPC分类号： C12Q1/689 ,  C12Q2600/158 ,  G01N33/56927 ,  G01N33/56933 ,  G01N2800/34 ,  G01N2800/36 ,  G01N2800/367

摘要： This invention relates to the detection of pathogens, in particular persistent forms of obligate intracellular or membrane associated microorganisms such as Chlamydia, Mycoplasma and Ureaplasma species, in blood samples, in particular in plasma and serum samples. Methods and kits of the invention may be useful in detecting pathogen infections and assessing pathogen-associated disease conditions and also for development and screening of new anti-microbial drugs, products and therapies.

公开(公告)号：EP1757938A4

公开(公告)日：2008-01-09

申请号：EP05741432

申请日：2005-05-19

申请人： ASTELLAS PHARMA INC ,  YAMADA TETSUO ,  MITA HARUHISA

发明人： YAMADA TETSUO ,  MITA HARUHISA ,  KUROMITSU SADAO ,  YOKOTA HIROYUKI ,  MORITA SHUJI ,  HIRAMOTO MASASHI ,  YURI MASATOSHI

IPC分类号： G01N33/573 ,  C12Q1/28 ,  C12Q1/37 ,  G01N33/493

CPC分类号： G01N33/573 ,  C12Q1/28 ,  C12Q1/37 ,  G01N2333/908 ,  G01N2333/966 ,  G01N2800/34

摘要： By finding that a high Azur granule content and its activity are observed in the feces and urine of IC patients, a method of examining IC is established. Namely, a method of examining interstitial cystitis by using the dynamic state of Azur granules in the urine as a marker; a kit for method of examining interstitial cystitis to be used in the above examination method; use of Azur granules as a marker for examining interstitial cystitis or evaluating a drug effect; and a method of examining a therapeutic effect on patients with interstitial cystitis by using Azur granules as a marker.

公开(公告)号：EP1733237A2

公开(公告)日：2006-12-20

申请号：EP05707736.4

申请日：2005-03-11

申请人： Bayer HealthCare AG

发明人： GOLZ, Stefan ,  BRÜGGEMEIER, Ulf ,  GEERTS, Andreas

IPC分类号： G01N33/68 ,  C12Q1/68 ,  A61P25/00 ,  C07K14/71 ,  G01N33/579 ,  A61P35/00 ,  A61P29/00 ,  A61P11/00 ,  A61K39/395 ,  A61K38/00 ,  A61K47/46 ,  A61K31/70

CPC分类号： G01N33/6896 ,  G01N33/57407 ,  G01N33/6893 ,  G01N2500/00 ,  G01N2800/06 ,  G01N2800/12 ,  G01N2800/22 ,  G01N2800/28 ,  G01N2800/32 ,  G01N2800/34

摘要： The invention provides a human PPARA which is associated with the cardiovascular diseases, gastroenterological diseases, cancer, inflammation, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, gastroenterological diseases, cancer, inflammation, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PPARA as well as pharmaceutical compositions comprising such compounds.

公开(公告)号：EP1648492A2

公开(公告)日：2006-04-26

申请号：EP04777402.1

申请日：2004-07-01

申请人： University of Maryland, Baltimore ,  The Government of the United States of America, represented by the Secretary, Department of Health and Human Services

发明人： KEAY, Susan, K. ,  SZEKELY, Zoltan ,  MICHEJDA, Christopher

IPC分类号： A61K38/16

CPC分类号： C07K9/005 ,  A61K38/00 ,  C07K7/06 ,  G01N33/6893 ,  G01N2800/34

摘要： A novel antiproliferative factor comprising a glycopeptide is disclosed. In specific embodiments, the novel antiproliferative factor is associated with the bladder. Compositions, diagnostic kits and reagents, and methods of using the compounds for identifying and/or treating interstitial cystitis and cancer are disclosed.