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51.发明授权
公开(公告)号：EP0607128B2
公开(公告)日：2007-02-21
申请号：EP91914752.0
申请日：1991-08-19
发明人： GEISSLINGER, Gerd , BRUNE, Kay
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52.发明公开PROCESS FOR PREPARING (+)-2-(4-CHLOROPHENYL)-3-METHYL BUTANOIC ACID 审中-公开制备的（+） - 2-（4-氯 - 苯基）-3-甲基丁酸
公开(公告)号：EP1583732A1
公开(公告)日：2005-10-12
申请号：EP03700048.6
申请日：2003-01-03
发明人： REDDY, Vaddu, Venkata, Narayana , ISHRATULLAH, Khwaja , RAJU, Penumatcha, Venkata, Krishnam , RAJU, Bhimapaka, China , RAO, Attaluri, Narasimha , BABU, Tella, Ramesh
CPC分类号： C07C51/412 , C07C51/02 , C07C51/43 , C07C57/58
摘要： The present invention relates to an environmentally benign process for preparation of (+)2-(4-chlorophenyl)-3-methyl butanoic acid (+ CPA) from its racemic acid, using optically active arylamines like (-) PEA in hydrophilic/hydrophobic organic solvents like butanol, propanol etc. as aqueous mixtures, separating the desired (+) CPA salt, mother liquor by filtration and refining the (+) CPA salt in the same solvent system as used for resolution, recovering the desired acid in high optical purity by extracting with aqueous mineral acid. The mother liquor is concentrated under vacuum and extracted with aqueous mineral acid to obtain undesired (-) CPA which was recovered and recycled after racemization. The aqueous mineral acid layer thus obtained is mixed with corresponding aqueous mineral acid layer obtained from (+) CPA recovery and extracted with aqueous caustic lie solution to recover the optically active amine used for resolution. Thus the method described effectively provides a process for recovery and recycle of the undesired (-) CPA, optically active amine, besides obtaining the desired (+) CPA in high optical purity.
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53.发明公开COMPOUNDS AND METHODS FOR THE INHIBITION OF PROTEIN-PROTEIN INTERACTIONS 审中-公开化合物和方法抑制蛋白质 - 蛋白质相互作用的
公开(公告)号：EP1038021A4
公开(公告)日：2005-02-16
申请号：EP98961858
申请日：1998-12-02
申请人： WAY JEFFREY C
发明人： WAY JEFFREY C
IPC分类号： G01N33/50 , A61K45/00 , C07B61/00 , C07C57/58 , C07C205/37 , C40B30/04 , C40B40/04 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/68 , C12Q1/00 , C12Q1/68 , C12Q1/70 , G01N33/543
CPC分类号： G01N33/6845 , C40B30/04 , C40B40/00 , G01N33/68
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54.发明公开INTERMEDIATE HALOPHENYL DERIVATIVES AND THEIR USE IN A PROCESS FOR PREPARING AZOLE DERIVATIVES 有权HALOGENPHENYLDERIVATZWISCHEN产品和它们使用在一种生产吡咯衍生物
公开(公告)号：EP1399402A1
公开(公告)日：2004-03-24
申请号：EP02754691.0
申请日：2002-06-17
发明人： SOUKUP, Milan
IPC分类号： C07C29/34 , C07C33/48 , C07C57/58 , C07C51/285 , C07C51/29 , C07D249/08 , C07D417/06
CPC分类号： C07D231/12 , C07C33/483 , C07D233/56 , C07D249/08
摘要： Novel halophenyl derivatives of the general formula (I), wherein R1 is halogen, a leaving group or 1H-1,2,4-triazol-l-yl and R2 is ethynyl or carboxy, X1 is halogen and X?2 and X3¿ are each independently hydrogen or halogen, and their manufacture are described. They are intermediates for manufacturing azole derivatives of the general formula (V) which are valuable medicaments useful for treating systemic mycoses.
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公开(公告)号：EP1207148A1
公开(公告)日：2002-05-22
申请号：EP01126255.7
申请日：2001-11-06
申请人： Clariant GmbH
CPC分类号： C07C51/10 , C07C67/36 , C07C57/32 , C07C57/58 , C07C69/612
摘要： Verfahren zur Herstellung von Phenylessigsäurederivaten der allgemeinen Formel (I) durch Umsetzung von Benzylchloriden der allgemeinen Formel (II)
mit einer Verbindung der allgemeinen Formel R 6 OH und mit Kohlenmonoxid in einem dipolar aprotischen Lösungsmittel in Gegenwart eines Katalysators, der mindestens eine Verbindung eines Übergangsmetalls der VIII. Nebengruppe des Periodensystems enthält,
wobei R 1 , R 2 , R 3 , R 4 , und R 5 unabhängig voneinander für folgende Reste stehen: ein Wasserstoff oder Fluoratom;
ein CH 2 CI-Rest;
eine HO 2 CCH=CH-, NC- oder CF 3 -Gruppe;
einen Alkyl-, Alkoxy-, oder Acyloxyrest, mit jeweils 1 bis 18 Kohlenstoffatomen; oder einen C 6 -C 18 -Aryloxy, Aryl- oder Heteroarylrest, wobei als Heteroatome 1 bis 3 Atome der Gruppe O, N und/oder S vorhanden sind;
einen R 8 2 P(=O)-, R 9 C(=O)-, R 9 OC(=O)-, R 9 OC(=O)CH=CH-, R 10 C(=O)-, R 10 OC(=O)-, R 10 OC(=O)CH=CH-, oder R 10 2 P(=O)-Rest, worin R 8 einen C 1 -C 4 -Alkylrest, R 9 einen C 1 -C 18 -Alkylrest oder Wasserstoff und R 10 einen C 6 -C 18 -Arylrest darstellen;
oder worin mindestens zwei der Reste R 1 , R 2 , R 3 , R 4 , und R 5 untereinander verknüpft sind und mindestens einen aliphatischen oder aromatischen Ring mit 5 bis 18 C-Atomen bilden;
R 6 steht für Wasserstoff oder einen C 1 -C 18 -Alkyl- oder C 6 -C 18 -Arylrest.摘要翻译： 由通式（II）
的苄基氯与通式R <6> OH，并用在偶极非质子溶剂的一氧化碳在催化剂的存在下包括至少一个化合物反应制备通式（I）的苯乙酸衍生物的制备方法 含有周期表第VIII族过渡基，其中R <1>，R <2>，R <3>，R <4>和R <5>是，独立地，以下基团：。氢原子或氟原子的过渡金属的化合物; 一个的CH 2 Cl基团; 一个HO2CCH = CH-，NC或CF 3基团; 烷基，烷氧基，或酰氧基，每一个具有1至18个碳原子; 或C6-C18芳氧基，芳基或杂芳基，其中该基团O，N和/或S的1至3个原子是存在杂原子; A R <8> 2P（= O） - ，R <9> C（= O） - ，R <9> OC（= O） - ，R <9> OC（= O）CH = CH-，R < 10> C（= O） - ，R <10> OC（= O） - ，R <10> OC（= O）CH = CH-，或R <10> 2 P（= O）部分，其中R < 8>的C1-C4烷基，R <9>和R <10>表示C1-C18烷基或氢，C6-C18芳基; 或其中至少两个所述基团R <1>，R <2>，R <3>，R <4>和R <5>被彼此连接并形成至少一种脂肪族或碳原子数5〜18的芳香族环; [R <6>为氢或C1-C18烷基或C6-C18芳基。 -
公开(公告)号：EP1029846A1
公开(公告)日：2000-08-23
申请号：EP99301161.8
申请日：1999-02-17
CPC分类号： C07C51/487 , C07C59/64
摘要： A method of resolving d- and I-isomers of an α-arylpropionic acid, wherein the isomers are enantiomers. The method involves forming an ammonium salt of the α-arylpropionic acid, then dissolving in a solvent the ammonium salt, and a chiral agent capable of reacting with the ammonium salt of at least one of the isomers. The reaction product of the chiral agent and the ammonium salt of the one of the isomers can subsequently be purified, then separated into the chiral agent and the isomer.
摘要翻译： 一种拆分α-芳基丙酸的异构体和异构体的方法，其中异构体是对映异构体。 该方法包括形成α-芳基丙酸的铵盐，然后在溶剂中溶解铵盐，以及能够与至少一种异构体的铵盐反应的手性试剂。 随后可以将手性试剂和一种异构体的铵盐的反应产物纯化，然后分离成手性试剂和异构体。
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57.发明授权STEREO-SELECTIVE SYNTHESIS OF 2-ARYL-PROPIONIC ACIDS OF HIGH OPTICAL PURITY BY USING CHIRAL OXAZOLINES 失效2-芳基丙高光学纯度STEREO选择性合成手性恶唑啉
公开(公告)号：EP0641304B1
公开(公告)日：1998-04-08
申请号：EP93902775.1
申请日：1992-12-28
CPC分类号： C07D491/04 , C07C33/20 , C07C51/00 , C07D263/14 , C07C59/64 , C07C57/58 , C07C57/30
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58.发明授权
公开(公告)号：EP0607128B1
公开(公告)日：1997-09-17
申请号：EP91914752.0
申请日：1991-08-19
发明人： GEISSLINGER, Gerd , BRUNE, Kay
摘要： Described are drugs for the treatment of painful and/or inflammatory conditions with flurbiprofen, the previously separated enantiomers of flurbiprofen being combined in the ratio 99.5-0.5 % to 0.5-99.5 % and processed with the usual pharmaceutical vehicles and additives to give drugs. For pain, or chronic conditions in which pain is a dominant factor, the mixture of enantiomers contains 50-99.5 %, preferably 60-95 %, of R(-)-fluorbiprofen and for inflammations, or chronic conditions in which inflammation is a dominant factor, the mixture contains 50-99.5 %, preferably 60-95 %, of S(+)-flurbiprofen.
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59.发明公开GAMMA-SUBSTITUTED PHENYLACETIC ACID DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND AGRICULTURAL BACTERICIDE CONTAINING THE SAME 失效GAMMA - 取代苯乙酸衍生物，METHOD FOR为国家有效合作PRODUCING和含有杀菌剂
公开(公告)号：EP0754672A1
公开(公告)日：1997-01-22
申请号：EP95914518.6
申请日：1995-04-06
申请人： SHIONOGI & CO., LTD.
IPC分类号： C07C57/30 , C07C57/58 , C07C59/48 , C07C59/52 , C07C59/64 , C07C69/612 , C07C69/73 , C07C205/53 , C07C229/34 , C07C233/11 , C07C235/32
CPC分类号： C07D295/195 , C07C57/48 , C07C57/58 , C07C59/68 , C07C69/734 , C07C69/736 , C07C229/36 , C07C235/34 , C07C237/20 , C07C251/16 , C07C251/24 , C07C257/14 , C07C317/18 , C07C317/46 , C07C323/45 , C07C323/56 , C07C323/60 , C07C327/22 , C07C327/44 , C07C327/58 , C07C2601/02 , C07C2601/14 , C07C2602/08
摘要： An α-substituted phenylacetic acid derivative useful as an agricultural fungicide, represented by general formula (I), or a salt thereof, a process for producing the same, an intermediate for the production thereof, and an agricultural fungicide containing the same as the active ingredient, wherein R 1 represents halogen, alkyl, OH, alkylthio, alkylsulfinyl, alkylsulfonyl, amino or nitro; Q represents aryl, heterocycle, mono- or disubstituted methyleneamino, (substituted amino-)methyl, alkyl, alkenyl, alkynyl, substituted carbonyl or substituted sulfonyl; X represents hydrogen, halogen, alkyl or OH; Y represents OH, alkylthio or amino; Z represents oxygen or sulfur; M represents oxygen, S(O)i (i being 0, 1 or 2), NR 2 (R 2 being hydrogen, alkyl or acyl) or a single bond; and n represents 0, 1 or 2.
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60.发明授权A process for the alpha-monoalkylation of arylacetonitriles, arylacetoesters and arylacetic acids 失效一种用于arylacetonitriles的αMonoalkierung，Arylacetoestern和芳基乙酸的过程
公开(公告)号：EP0525506B1
公开(公告)日：1996-05-01
申请号：EP92112028.3
申请日：1992-07-15
IPC分类号： C07C253/30 , C07C255/41 , C07C67/343 , C07C57/30 , C07C57/58 , C07C59/84 , C07C255/40
CPC分类号： C07C51/347 , C07C57/30 , C07C59/58 , C07C59/64 , C07C67/343 , C07C253/30
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