Abstract:
In one aspect, the present invention encompasses integrated processes for the conversion of epoxides to acrylic acid derivatives and polyesters. In certain embodiments, the methods of the present invention comprise the steps of: providing a feedstock stream comprising an epoxide and carbon monoxide; contacting the feedstock stream with a metal carbonyl in a first reaction zone to effect conversion of at least a portion of the provided epoxide to a beta lactone; directing the effluent from the first reaction zone to a second reaction zone where the beta lactone is subjected to conditions that convert it to a compound selected from the group consisting of: an alpha beta unsaturated acid, an alpha beta unsaturated ester, an alpha beta unsaturated amide, and an optionally substituted polypropiolactone polymer; and isolating a final product comprising the alpha-beta unsaturated carboxylic acid, the alpha-beta unsaturated ester, the alpha-beta unsaturated amide or the polypropiolactone.
Abstract:
The object of the present invention is to provide a process for producing ±-fluoroacrylic acid ester at a high starting material conversion, high selectivity, and high yield. The present invention provides a process for producing the compound represented by the formula (1) wherein R represents alkyl optionally substituted with one or more fluorine atoms, the process comprising step A of reacting a compound represented by the formula (2) wherein X represents a bromine atom or a chlorine atom with an alcohol represented by the formula (3) wherein the symbol is as defined above, and carbon monoxide in the presence of a transition metal catalyst and a base to thereby obtain the compound represented by the formula (1). €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒR-OH€ƒ€ƒ€ƒ€ƒ€ƒ(3)
Abstract:
Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with alcohols or water treated by photosensitizers are provided. The resultant carbon-isotope labeled esters and acids, and pharmaceutical acceptable salts and solvates are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits and method for PET studies are also provided.
Abstract:
The invention relates to a method for producing methyl methacrylate by reacting alpha-hydroxyisobutyramide with methyl formate in order to obtain methyl alpha-hydroxyisobutyrate and formamide, said methyl alpha-hydroxyisobutyrate being dehydrated to form methyl methacrylate, characterised in that at least one fraction of the methyl formate used in said reaction and/or at least one fraction of the alpha-hydroxyisobutyramide used in said reaction is obtained by a reaction or a series of reactions involving biomass.
Abstract:
A process for the liquid phase carbonylation of an alcohol and/or a reactive derivative thereof in the presence of hydrogen in which there is employed a catalyst comprising rhodium of iridium coordinated with a polydentate ligand.