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51.发明授权HEMATOPOIETIC GROWTH FACTOR DERIVED FROM T LYMPHOCYTES AND METHODS OF USE THEREFOR 失效OFF T淋巴细胞得到的造血生长因子，及其使用方法
公开(公告)号：EP0594764B1
公开(公告)日：2000-01-12
申请号：EP92916012.5
申请日：1992-07-07
申请人： Choudhury, Chandra
发明人： Choudhury, Chandra
IPC分类号： C12N15/27 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00 , C12N5/10 , C12Q1/68 , G01N33/53 , G01N33/564 , A61K38/00 , C12N1/21 , C12P21/02 , C12P21/08 , C12N5/00 , G01N33/68
CPC分类号： C12Q1/6876 , A61K38/00 , C07K14/53
摘要： A T cell-derived colony stimulating factor (TC-CSF) may be isolated from media conditioned with T lymphocyte cells. TC-CSF stimulates formation of colonies composed of granulocytes, macrophages, megakaryocytes, fibrocytic stromal cells, lymphocytes, and mixed colonies of granulocytes and macrophages. Anion exchange chromatography may be employed in conjunction with gel filtration and rpHPLC to isolate TC-CSF. Human TC-CSF and murine TC-CSF cDNA, mRNA, genomic DNA nucleotide and amino acid sequences, expression products, pharmaceutical formulations and antibody materials are specifically provided.
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公开(公告)号：EP0890640A3
公开(公告)日：1999-03-24
申请号：EP98113221.0
申请日：1994-01-27
申请人： AMGEN INC.
发明人： Osslund, Thimothy
CPC分类号： C07K1/00 , A61K38/00 , C07K14/535 , C07K2299/00 , C07K2319/00 , Y02A90/26
摘要： Provided herein are granulocyte colony stimulating factor ("G-CSF") analogs, compositions containing such analogs, and related compositions. In another aspect, provided herein are nucleic acids encoding the present analogs or related nucleic acids, related host cells and vectors. In yet another aspect, provided herein are computer programs and apparatuses for expressing the three dimensional structure of G-CSF and analogs thereof. In another aspect, provided herein are methods for rationally designing G-CSF analogs and related compositions. In yet another aspect, provided herein are methods for treatment using the present G-CSF analogs.
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公开(公告)号：EP0715633A4
公开(公告)日：1997-11-19
申请号：EP94922181
申请日：1994-07-28
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61P7/00 , C07K14/505 , C07K14/52 , C07K14/535 , C07K14/54 , C12N1/21 , C12N15/19 , C12P21/02 , C12R1/91 , C07K14/475 , C07K14/55 , C12N15/24 , C12N15/26 , C12N15/27
CPC分类号： C07K14/505 , A61K38/00 , C07K14/535 , C07K14/54
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公开(公告)号：EP0732401A3
公开(公告)日：1997-05-14
申请号：EP95119320.0
申请日：1990-08-07
摘要： A novel human megakaryocytopoietic factor capable of stimulating the growth and development of colonies of megakaryocytes is provided, including procedures for its purification and use as a pharmaceutical agent.
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公开(公告)号：EP0732401A2
公开(公告)日：1996-09-18
申请号：EP95119320.0
申请日：1990-08-07
摘要： A novel human megakaryocytopoietic factor capable of stimulating the growth and development of colonies of megakaryocytes is provided, including procedures for its purification and use as a pharmaceutical agent.
摘要翻译： 提供能够刺激巨核细胞集落生长和发育的新型人类巨核细胞生成因子，包括其纯化和用作药剂的方法。
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56.发明公开Cysteine added variants of EPO and chemical modifications thereof 失效Mitzusätzlichencysteinresten Varianten der EPO und chemische Modifikationen davon。
公开(公告)号：EP0668353A1
公开(公告)日：1995-08-23
申请号：EP95103989.0
申请日：1990-04-19
发明人： Shaw, Gray , Veldman, Geertruida , Wooters, Joseph
IPC分类号： C12N15/27 , C07K14/505 , C12P21/02 , C07K14/535
CPC分类号： C07K14/5403 , A61K38/00 , A61K47/60 , C07K14/505 , C07K14/535 , Y10S930/141
摘要： Cysteine added variants ("CAVs") of EPO are provided having one or more cysteine residues substituted for selected naturally occurring amino acid residues, or inserted into the polypeptide sequence, and preferably being further modified by deletion of certain N-terminal amino acids. Such CAVs may be additionally modified by the coupling of sulfhydryl reactive compounds to the introduced cysteine residue(s) without loss of bioactivity to produce selected homogeneously modified EPO and improved pharmaceutical compositions containing the same.
摘要翻译： 提供EPO的半胱氨酸添加变体（“CAV”），其具有一个或多个半胱氨酸残基取代了选定的天然存在的氨基酸残基，或插入到多肽序列中，优选通过缺失某些N-末端氨基酸进一步修饰。 可以通过将巯基反应性化合物偶联到引入的半胱氨酸残基而不丧失生物活性以产生选择的均匀修饰的EPO和包含其的改进的药物组合物来另外修饰这样的CAV。
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公开(公告)号：EP0402070B1
公开(公告)日：1994-08-17
申请号：EP90306042.4
申请日：1990-06-04
申请人： SCHERING CORPORATION
发明人： Reichert, Paul , Hammond, Gerald S. , Le, Hung V. , Nagabhushan, Tattanahali L. , Trotta, Paul P.
CPC分类号： C07K14/535 , Y10S930/145
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公开(公告)号：EP0540575A4
公开(公告)日：1994-06-08
申请号：EP91913186
申请日：1991-07-02
发明人： MURPHY MARTIN J , PARCHMENT RALPH E , ERICKSON-MILLER CONNIE L , DAI WEI DR , ZHANG ZHAO-GENG , LIOTTA LANCE A , KRUTZSCH HENRY
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公开(公告)号：EP0561429A1
公开(公告)日：1993-09-22
申请号：EP93108721.7
申请日：1990-06-04
申请人： SCHERING CORPORATION
发明人： Reichert, Paul , Hammond, Gerald S. , Le, Hung V. , Nagabhushan, Tattanalhali L. , Trotta, Paul P Biotechnology Dept.,
CPC分类号： C07K14/535 , Y10S930/145
摘要： A method of preparing a crystalline form of recombinant human granulocyte-macrophage colony-stimulating factor (r-h-GM-CSF) using polyethylene glycol with molecular weight of about 8000.
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60.发明授权cDNA CLONES CODING FOR POLYPEPTIDES EXHIBITING HUMAN GRANULOCYTE MACROPHAGE AND EOSINOPHIL CELLULAR GROWTH FACTOR ACTIVITY 失效用于多肽的CDNA克隆编码展示人粒细胞巨噬细胞和人卵巢细胞生长因子活性
公开(公告)号：EP0202300B1
公开(公告)日：1992-11-11
申请号：EP85906001.4
申请日：1985-11-18
CPC分类号： C07K14/535 , A61K38/00
摘要： Plasmid vectors that carry complementary DNA (cDNA) clones coding for polypeptides exhibiting human granulocyte/macrophage colony stimulating factor activity, including eosinophil growth factor activity. One of these polypeptides is about 144 amino acids in length, including a potential leader sequence. The cDNA is derived from messenger RNA isolated from a human cell source after activation with concanavalin A. The cDNA was cloned by incorporation into a plasmid vector, which was then transformed into E. coli. The plasmid vector also contained DNA segments from the SV40 virus, permitting expression of the cDNA after transfection into a mammalian host cell, such as monkey COS-7 cells.
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