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54 条记录 (耗时 0.017 秒)

    Human Fc-gamma receptor
    4.
    发明公开
    Human Fc-gamma receptor 失效
    人类FC-GAMMA受体

    公开(公告)号：EP0319307A3

    公开(公告)日：1989-08-30

    申请号：EP88311408.4

    申请日：1988-12-01

    申请人： Schering Biotech Corporation

    发明人： Moore, Kevin W. ,  Peltz, Gary A.

    IPC分类号： C12N15/00 ,  A61K37/02 ,  G01N33/566

    CPC分类号： G01N33/564 ,  C07K14/70535

    摘要： A cDNA clone is provided which encodes a human receptor for the Fc portion of immunoglobulin G. Soluble forms of the receptor may be useful in treating disorders associated with excessive immunoglobulin G production. Cells expressing membrane-bound forms of the receptor are useful in assays for immune complexes, elevated levels of which are associated with numerous disease states, including systemic lupus erythematosus (SLE) and rheumatoid arthritis.

    Expression vectors for the production of human Granulocyte-Macrophage Colony Stimulation Factor in a mammalian cell host(18.05.92)
    5.
    发明公开
    Expression vectors for the production of human Granulocyte-Macrophage Colony Stimulation Factor in a mammalian cell host(18.05.92) 失效
    在Sängerzellen生产人造血GM-CSF。

    公开(公告)号：EP0299782A2

    公开(公告)日：1989-01-18

    申请号：EP88306486.7

    申请日：1988-07-15

    申请人： Schering Biotech Corporation

    发明人： Yokota, Takashi ,  Lee, Frank D. ,  Rennick, Donna M. ,  Arai, Ken-ichi ,  Arai, Naoko

    IPC分类号： C12N15/00 ,  C12P21/02

    CPC分类号： C07K14/535 ,  A61K38/00

    摘要： Human granulocyte-macrophage colony stimulating factor (GM-CSF) polypeptides are provided, as well as methods for synthesizing conformationally and antigenically neutral muteins. The disclosed GM-CSFs promote growth and development of various hematopoietic lineages, and may be useful in treating conditions involving depressed blood cell populations and/or depressed blood cell regeneration, such as myeloid hypoplasia, chronic infections, and hematopoiesis after bone marrow transplantation. The invention also includes a novel mammalian expression vector.

    摘要翻译： 提供人粒细胞 - 巨噬细胞集落刺激因子（GM-CSF）多肽，以及合成和抗原性中性突变蛋白的合成方法。 所公开的GM-CSF促进各种造血谱系的生长和发育，并且可用于治疗涉及抑制血细胞群体和/或抑制血细胞再生的病症，例如骨髓移植后骨髓发育不全，慢性感染和造血。 本发明还包括一种新型的哺乳动物表达载体。

    Murine-interleukin-2 muteins
    6.
    发明公开
    Murine-interleukin-2 muteins 失效
    Muteine des Maus-Interleukin-2。

    公开(公告)号：EP0267795A2

    公开(公告)日：1988-05-18

    申请号：EP87310005.1

    申请日：1987-11-12

    申请人： Schering Biotech Corporation

    发明人： Zurawski, Gerard ,  Zurawski, Sandra M.

    IPC分类号： C07K13/00

    CPC分类号： C12N15/70 ,  C07K14/55

    摘要： Mutant murine interleukin-2 proteins (muteins) are provided. Muteins containing deletions and/or substitutions within the first 30 N-terminal amino acids are almost all biologically active. The frequence of biologically active mutants is much lower for deletions and/or substitutions in other regions of the native protein.

    摘要翻译： 提供突变鼠白介素-2蛋白（突变蛋白）。 在前30个N-末端氨基酸中含有缺失和/或置换的突变蛋白几乎都具有生物活性。 生物活性突变体的频率对于天然蛋白质的其它区域中的缺失和/或置换而言要低得多。

    Synthetic genes for human interleukin 1-alpha
    7.
    发明公开
    Synthetic genes for human interleukin 1-alpha 失效
    Synthetische menschliche alpha-Interleukin-1-Gene。

    公开(公告)号：EP0259160A2

    公开(公告)日：1988-03-09

    申请号：EP87307781.2

    申请日：1987-09-03

    申请人： Schering Biotech Corporation

    发明人： Zurawski, Gerard ,  Zurawski, Sandra Marvo

    IPC分类号： C12N15/00 ,  C12P21/02 ,  C07H21/04

    CPC分类号： C07K14/545

    摘要： Synthetic human interleukin-1α genes are provided whose codons are selected from those preferred by bacteria. High expression levels are obtained in an E. coli expression system for both native interleukin-1α and several mutant interleukin-1α's.

    摘要翻译： 提供合成人白细胞介素-1α基因，其密码子选自细菌优选的那些。 在用于天然白细胞介素-1α和几种突变白细胞介素-1α的大肠杆菌表达系统中获得高表达水平。