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203 条记录 (耗时 0.015 秒)

    HIGHER FULLERENES USEFUL AS RADICAL SCAVENGERS
    55.
    发明公开
    HIGHER FULLERENES USEFUL AS RADICAL SCAVENGERS 审中-公开
    HÖHEREFULLERENE，DIE SICH ALSRADIKALFÄNGEREIGNEN

    公开(公告)号：EP1694629A4

    公开(公告)日：2007-01-10

    申请号：EP04814500

    申请日：2004-12-15

    申请人： NANO C INC

    发明人： KRONHOLM DAVID L ,  HUMMELEN JAN C

    IPC分类号： C07C69/74 ,  A61K31/095 ,  A61K31/135 ,  A61K31/137 ,  A61K31/165 ,  A61K31/192 ,  A61K31/21 ,  A61K31/235 ,  A61K31/26 ,  A61K31/66 ,  A61K31/704 ,  C01B20060101 ,  C07C69/00 ,  C07C69/76

    CPC分类号： B82Y30/00 ,  C07C69/00 ,  C07C69/616 ,  C07C2604/00

    摘要： Chemically functionalized fullerenes are useful in various applications as radical scavengers. These chemically functionalized fullerenes offer the advantages of preservation of the high innate radical scavenging efficiency of the fullerene cage and ease of synthesis of fullerene derivatives of desirably altered chemical and physical properties and single isomers. Further, they are based on a common intermediate chemistry and intermediates can be easily functionalized and tailored to various requirements.

    摘要翻译： 化学官能化的富勒烯可用作各种应用中的自由基清除剂。 这些化学官能化的富勒烯具有保存富勒烯笼的高固有自由基清除效率和容易合成富勒烯衍生物的优点，其具有理想的改变的化学和物理性质和单一异构体。 此外，它们基于通用的中间体化学品，中间体可以容易地进行功能化并根据各种要求进行定制。

    IRREVERSIBLE SELECTIVE ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF
    56.
    发明公开
    IRREVERSIBLE SELECTIVE ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF 审中-公开
    雄激素受体和应用过程为不可逆的，选择性调节剂

    公开(公告)号：EP1487783A4

    公开(公告)日：2006-09-27

    申请号：EP03710820

    申请日：2003-02-24

    申请人： UNIV TENNESSEE RES FOUNDATION

    发明人： DALTON JAMES ,  MILLER DUANE D ,  KIRKOVSKY LEONID I ,  HWANG DONG JIN ,  STEINER MITCHELL S ,  VEVERKA KAREN A ,  MUKHERJEE ARNAB

    IPC分类号： A61P5/28 ,  A61K31/16 ,  A61K31/26 ,  A61K31/275 ,  A61P15/16 ,  A61P27/02 ,  A61P35/00 ,  C07C233/05 ,  C07C255/50 ,  C07C331/28

    CPC分类号： C07C331/10 ,  C07C261/02 ,  C07C265/12 ,  C07C331/28

    摘要： In one embodiment, this invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). The SARM compounds have unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor. In one embodiment, the SARM compounds bind irreversibly to the androgen receptor. In another embodiment, the SARM compounds are androgen receptor antagonists which bind irreversibly to the androgen receptor. In another embodiment, the SARM compounds are alkylating agents. The SARM compounds, either alone or as a composition, are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and/or prevention of acute and/or chronic muscular wasting conditions; e) preventing and/or treating dry eye conditions; f) oral androgen replacement therapy; g) decreasing the incidence of, halting or causing a regression of prostate cancer; and/or h) inducing apoptosis in a cancer cell.

    A METHOD OF TREATING BREAST CANCER WITH ANDROGEN RECEPTOR ANTAGONISTS
    58.
    发明公开
    A METHOD OF TREATING BREAST CANCER WITH ANDROGEN RECEPTOR ANTAGONISTS 审中-公开
    方法乳腺癌与雄激素受体拮抗剂治疗

    公开(公告)号：EP1594489A2

    公开(公告)日：2005-11-16

    申请号：EP04703607.4

    申请日：2004-01-20

    申请人： GTX, Inc.

    发明人： STEINER, Mitchell, S. ,  DALTON, James, T. ,  MILLER, Duane, D. ,  VEVERKA, Karen, A.

    IPC分类号： A61K31/21 ,  A61K31/26

    CPC分类号： A61K31/66 ,  A61K31/21 ,  A61K31/26

    摘要： This invention relates to the prevention and treatment of breast cancer in a subject, for example a female subject. Accordingly, this invention provides methods of a) treating a subject suffering from breast cancer; b) preventing, suppressing, inhibiting or reducing the incidence of breast cancer in a subject; c) delaying the progression of breast cancer in a subject suffering from breast cancer; d) preventing the recurrence of breast cancer in a subject; e) treating the recurrence of breast cancer in a subject suffering from breast cancer; and/or f) treating, preventing, suppressing or inhibiting metastasis in a subject suffering from breast cancer, by administering to the subject a therapeutically effective amount of an Androgen Receptor Antagonist and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, phatmaceutical product, hydrate, N-Oxide, crystal polymorph, prodrug or any combination thereof, as described herein.