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114 条记录 (耗时 0.016 秒)

    METHOD FOR TREATING DISEASES USING HSP90-INHIBITING AGENTS IN COMBINATION WITH ANTIMETABOLITES
    62.
    发明公开
    METHOD FOR TREATING DISEASES USING HSP90-INHIBITING AGENTS IN COMBINATION WITH ANTIMETABOLITES 有权
    方法与HSP90消炎药疾病的联合抗代谢物治疗

    公开(公告)号：EP1631267A2

    公开(公告)日：2006-03-08

    申请号：EP04776158.0

    申请日：2004-05-28

    申请人： Kosan Biosciences, Inc.

    发明人： JOHNSON, Robert, Jr. ,  ZHOU, Yiqing ,  MÜLLER, Thomas

    IPC分类号： A61K31/00

    CPC分类号： A61K31/513 ,  A61K31/395 ,  A61K31/522 ,  A61K31/525 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention provides a method for treating cancer. The method involves the administration of an HSP90 inhibitor and an antimetabolite, where the combined administration provides a synergistic effect. In one aspect of the invention, a method of treating cancer is provided where a subject is treated with a dose of an HSP90 inhibitor in one step and a dose of an antimetabolite in another step. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an HSP90 inhibitor and subsequently treated with a dose of an antimetabolite. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an antimetabolite and subsequently treated with a dose of an HSP90 inhibitor.

    METHOD FOR TREATING DISEASES USING HSP90-INHIBITING AGENTS IN COMBINATION WITH PLATINUM COORDINATION COMPLEXES
    63.
    发明公开
    METHOD FOR TREATING DISEASES USING HSP90-INHIBITING AGENTS IN COMBINATION WITH PLATINUM COORDINATION COMPLEXES 审中-公开
    17烷基氨基-17- desmethoxygeldanamycin和奥沙利铂在乳腺癌和结肠直肠癌的治疗中的用途

    公开(公告)号：EP1628657A2

    公开(公告)日：2006-03-01

    申请号：EP04753658.6

    申请日：2004-05-28

    申请人： Kosan Biosciences, Inc.

    发明人： JOHNSON, Robert, Jr. ,  ZHOU, Yiqing ,  MÜLLER, Thomas

    IPC分类号： A61K31/33 ,  A61K31/28

    CPC分类号： A61K33/24 ,  A61K31/28 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention provides a method for treating cancer. The method involves the administration of an HSP90 inhibitor and a platinum coordination complex, where the combined administration provides a synergistic effect. In one aspect of the invention, a method of treating cancer is provided where a subject is treated with a dose of an HSP90 inhibitor in one step and a dose of a platinum coordination complex in another step. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an HSP90 inhibitor and subsequently treated with a dose of a platinum coordination complex. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of a platinum coordination complex and subsequently treated with a dose of an HSP90 inhibitor.

    METHODS TO ADMINISTER EPOTHILONE D
    64.
    发明公开
    METHODS TO ADMINISTER EPOTHILONE D 审中-公开
    管理方法埃坡霉素D的

    公开(公告)号：EP1575556A2

    公开(公告)日：2005-09-21

    申请号：EP03817031.2

    申请日：2003-05-20

    申请人： Kosan Biosciences, Inc.

    发明人： JOHNSON, JR., Robert G. ,  SHERRILL, Michael ,  HANNAH, Alison

    IPC分类号： A61K9/00

    CPC分类号： A61K31/427

    摘要： Methods to deliver epothilone D to subjects having tumorigenic diseases are provided. In some embodiments, the invention provides methods for treating tumor-bearing subjects with an intravenous infusion of epothilone D al least one about every seven days throughout a delivery period of about twenty-one consecutive day period.

    BENZOQUINONE ANSAMYCINS
    68.
    发明公开
    BENZOQUINONE ANSAMYCINS 审中-公开
    苯醌ANSAMYCINS

    公开(公告)号：EP1420747A2

    公开(公告)日：2004-05-26

    申请号：EP02768436.4

    申请日：2002-08-05

    申请人： Kosan Biosciences, Inc.

    发明人： SANTI, Daniel ,  MYLES, David, C. ,  TIAN, Zong-Qiang ,  HUTCHINSON, C., Richard ,  JOHNSON, Robert ,  ZHOU, Yi-Qing ,  FENG, Li

    IPC分类号： A61K6/00

    CPC分类号： C07D491/08 ,  C07D225/06

    摘要： The invention relates to benzoquinone ansamycin analogs useful for the treatment of cancer and other diseases or conditions characterized by undesired cellular proliferation or hyperproliferation. Therapies involving the administration of such benzoquinone ansamycin analogs, optionally in combination with an inhibitor of an HSP90 client protein, are useful to treat cancer and non-cancerous disease conditions.

    摘要翻译： 本发明涉及可用于治疗以不希望的细胞增殖或过度增殖为特征的癌症和其他疾病或病症的苯醌安沙霉素类似物。 涉及施用此类苯醌安沙霉素类似物的治疗，任选地与HSP90客户蛋白抑制剂组合用于治疗癌症和非癌性疾病状况。

    LAULIMALIDE DERIVATIVES
    69.
    发明公开
    LAULIMALIDE DERIVATIVES 审中-公开
    LAULIMALIDE衍生物

    公开(公告)号：EP1358186A1

    公开(公告)日：2003-11-05

    申请号：EP02703356.2

    申请日：2002-02-08

    申请人： Kosan Biosciences, Inc.

    发明人： ASHLEY, Gary ,  METCALF, Brian

    IPC分类号： C07D417/06 ,  C07D493/18 ,  C07D493/08 ,  A61K31/335

    CPC分类号： C07D493/08

    摘要： Laulimalide compounds, intermediates thereto and methods for their preparation and methods for their use in the treatment of diseases characterized by cellular hyperproliferation. Formula (I).

    摘要翻译： 劳拉米尔化合物，其中间体及其制备方法和它们用于治疗以细胞过度增殖为特征的疾病的方法。 公式（I）。