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61.发明公开COMPOSITION OF TUMOR-ASSOCIATED PEPTIDES AND RELATED ANTI-CANCER VACCINE FOR THE TREATMENT OF GLIOBLASTOMA (GBM) AND OTHER CANCERS 有权肿瘤相关肽和相关抗癌疫苗的组合用于治疗脑胶质瘤（GBM）和其他癌症
公开(公告)号：EP2331118A1
公开(公告)日：2011-06-15
申请号：EP09778749.3
申请日：2009-09-28
发明人： SCHOOR, Oliver , HILF, Norbert , WEINSCHENK, Toni , TRAUTWEIN, Claudia , WALTER, Steffen , SINGH, Harpreet
CPC分类号： A61K39/0011 , A61K35/17 , A61K38/00 , A61K2039/5154 , A61K2039/5158 , A61K2039/53 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , A61K2039/55588 , A61K2039/572 , A61K2039/605 , A61K2039/6081 , A61K2039/6093 , A61M5/002 , C07K7/06 , C07K7/08 , C07K14/70539 , C07K2319/00 , C07K2319/40 , C12N5/0638 , C12N2501/50 , G01N33/57492 , Y02A50/472
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 25 novel peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
摘要翻译： 本发明涉及免疫治疗肽及其在免疫治疗中的应用，特别是癌症的免疫治疗。 本发明公开了单独或与其他肿瘤相关肽组合的肿瘤相关T辅助细胞肽表位，其作为刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分。 特别地，本发明的肽的组合物可用于引发针对神经胶质瘤的抗肿瘤免疫应答的疫苗组合物中。
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公开(公告)号：EP2183278A2
公开(公告)日：2010-05-12
申请号：EP08785106.9
申请日：2008-07-25
发明人： SINGH, Harpreet , SCHOOR, Oliver , TRAUTWEIN, Claudia , HILF, Norbert , WEINSCHENK, Toni , WALTER, Steffen , LEWANDROWSKI, Peter
CPC分类号： A61K39/0011 , A61K35/17 , A61K2039/5158 , A61K2039/572 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/4748 , C07K14/495 , C07K14/7051 , C07K16/40 , C07K19/00 , C07K2317/34 , C07K2319/00 , C12N5/0638 , C12N9/0036 , C12N9/13 , C12N2502/1157 , C12Y208/02011
摘要： The present invention relates to amino acid sequences of peptides derived from tumour associated antigens that are able to bind to MHC complexes of either class, and elicit an immune response, as well as to uses of said peptides for the treatment of diseases.
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63.发明公开IMMUNOGENIC T-HELPER EPITOPES FROM HUMAN TUMOUR ANTIGENS AND IMMUNOTHERAPEUTIC METHODS USING SAID EPITOPES 有权人类肿瘤抗原的免疫原性T辅助表位和它们在免疫治疗方法
公开(公告)号：EP1794190A2
公开(公告)日：2007-06-13
申请号：EP05778354.0
申请日：2005-09-09
IPC分类号： C07K14/47
CPC分类号： C07K14/4748
摘要： The present invention relates to immunotherapeutic methods, and molecules and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer, in particular renal cancer. The present invention furthermore relates to tumour-associated T-helper cell peptide epitopes, alone or in combination with other tumour-associated peptides, that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumour immune responses. In particular, the present invention relates to 338 novel peptide sequences derived from HLA class II molecules of human tumour cell lines which can be used in vaccine compositions for eliciting anti-tumour immune responses.
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公开(公告)号：EP4448108A1
公开(公告)日：2024-10-23
申请号：EP22830069.5
申请日：2022-11-08
IPC分类号： A61P35/00 , A61K35/17 , C07K14/725 , C07K16/28 , C07K16/30
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65.发明公开
公开(公告)号：EP4363858A1
公开(公告)日：2024-05-08
申请号：EP22735441.2
申请日：2022-06-28
发明人： SCHRÄDER, Christoph , SCHUSTER, Heiko , FREUDENMANN, Lena , GOLDFINGER, Valentina , KOWALEWSKI, Daniel , YOUSEF, Sara , MANZ, Timo , MIJOSEK, Vedrana , RÖMER, Michael , WEINSCHENK, Toni
IPC分类号： G01N33/68
CPC分类号： G01N33/6848 , G01N2333/7053920130101 , G01N2496/0020130101 , Y02A50/30 , A61K39/4611 , A61K39/464489 , A61K39/4632 , C12N5/0636
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66.发明公开
公开(公告)号：EP4180450A1
公开(公告)日：2023-05-17
申请号：EP22201204.9
申请日：2017-03-15
发明人： MAHR, Andrea , SCHOOR, Oliver , WEINSCHENK, Toni
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules (Fig. 1)
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67.发明公开
公开(公告)号：EP3919507A3
公开(公告)日：2022-01-12
申请号：EP21177102.7
申请日：2016-06-29
发明人： MAHR, Andrea , WEINSCHENK, Toni , HÖRZER, Helen , SCHOOR, Oliver , FRITSCHE, Jens , SINGH, Harpreet
摘要： Provided is a peptide of up to 30 amino acids comprising the amino acid sequence of SEQ ID NO: 217 or one of SEQ ID NOs: 1 to 10, 12 to 216 and 218 to 640. Provided are inter alia also a nucleic acid encoding such peptide, a host cell comprising the same, a T-cell receptor reactive with such peptide and an activated T lymphocyte recognizing a cell which presents such peptide. Provided is also the use of any of the above in cancer treatment.
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68.发明公开
公开(公告)号：EP3885356A1
公开(公告)日：2021-09-29
申请号：EP21165092.4
申请日：2017-02-17
发明人： SCHOOR, Oliver , MAHR, Andrea , WEINSCHENK, Toni , WIEBE, Anita , FRITSCHE, Jens , SINGH, Harpreet
IPC分类号： C07K14/47
摘要： The pres ent invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to an tumor-associated T-cell peptide epitope, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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69.发明公开
公开(公告)号：EP3852787A1
公开(公告)日：2021-07-28
申请号：EP19773780.2
申请日：2019-09-18
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70.发明公开
公开(公告)号：EP3712165A2
公开(公告)日：2020-09-23
申请号：EP20170129.9
申请日：2016-06-29
发明人： MAHR, Andrea , WEINSCHENK, Toni , HÖRZER, Helen , SCHOOR, Oliver , FRITSCHE, Jens , SINGH, Harpreet
摘要： Provided is a peptide of up to 30 amino acids comprising the amino acid sequence of SEQ ID NO: 3, SEQ ID NO: 1 or SEQ ID NO: 2, or one of SEQ ID NO: 4 to SEQ ID NO: 10 or SEQ ID NO: 12 to SEQ ID NO: 640. Provided are inter alia also a nucleic acid encoding such peptide, a host cell comprising the same, a T-cell receptor reactive with such peptide and an activated T lymphocyte recognizing a cell which presents such peptide. Provided is also the use of any of the above in cancer treatment.
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