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61.发明授权VERWENDUNG EINES ANTIKÖRPERS ZUR DETEKTION VON BASOPHILEN UND/ODER MASTZELLEN 有权抗体用于检测嗜碱性粒细胞和/或肥大细胞利用
公开(公告)号：EP1179179B1
公开(公告)日：2004-10-20
申请号：EP00929537.9
申请日：2000-05-17
IPC分类号： G01N33/53 , G01N33/574 , G01N33/58 , C12N5/08
CPC分类号： G01N33/56972 , C07K14/705 , C07K16/28
摘要： The invention relates to the use of an antibody to detect and/or quantify and/or isolate basophiles and/or mast cells and/or precursor cells of basophiles and/or mast cells and/or a surface structure of all of said cells. The antibody binds to the surface structure of the cells with which the antibody with the designation 97A6 can bond, whereby said antibody is produced from hybridome cells and is released. Said hybridome cells were deposited with the German Collection of Microorganisms and Cell Cultures, GMBH on 12.02.97 under the following number: DSM ACC 2297 in accordance with the Budapest Treaty.
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62.发明公开
公开(公告)号：EP1454141A1
公开(公告)日：2004-09-08
申请号：EP02785415.7
申请日：2002-11-28
发明人： BÜHRING, Hans-Jörg
IPC分类号： G01N33/68
CPC分类号： G01N33/6869 , C07K16/40 , G01N33/5047 , G01N2333/5403
摘要： The invention relates to a method for detecting allergies. A blood sample is incubated first with an agent acting on cells, preferably Interleukin IL-3, and then with an allergen that binds to those surface structures of basophiles and/or precursor cells of basophiles and/or mast cells to which antibody 97A6 can bind. Said antibody is produced and released by hybridome cells that were deposited according to the Budapest Treaty on 12.02.1997 with the Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, DSMZ, carrying number DSM ACC 2297. The antibodies bound to the basophiles and/or mast cells and/or precursor cells of basophiles are then quantified.
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公开(公告)号：EP0863157B1
公开(公告)日：2004-04-07
申请号：EP97122273.2
申请日：1997-12-17
IPC分类号： C07K16/28 , C12N5/20 , G01N33/577 , G01N33/574 , A61K39/395 , A61P35/02
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公开(公告)号：EP1276878A2
公开(公告)日：2003-01-22
申请号：EP01915354.3
申请日：2001-03-15
IPC分类号： C12N15/63 , C12N15/90 , C12N15/12 , C12N15/37 , C12N15/38 , C12N9/00 , C12N9/12 , C12N15/85 , C12N15/86 , C12N5/10 , A61K48/00 , A61K35/12 , A61P43/00
CPC分类号： C12N15/85 , C12N15/63 , C12N2510/04
摘要： A gene complex for reversible immortalization of cells contains an immortalizing gene domain including at least one resistance gene, an immortalization gene and preferably a suicide gene, in addition to sequences flanking said gene domain and acting as a recognition point for homologous, intermolecular recombination, as well as at least one promoter (fig. 1) which prefixes the gene domain. A gene complex for immunomodulation of cells contains a first immunomodulated gene domain whose expression inhibits the function of MHC I molecules, a second immunomodulating gene domain whose expression results in an inactivation of natural killer cells, and a resistance gene. Organ-related cells are provided according to a method for obtaining cells; said cells are immortalized by transferring the first gene complex and are immunomodulated by transferring the second gene complex. The immortalization is reversed after expansion of the immortalized cells has occurred.
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65.发明公开VERFAHREN UND VORRICHTUNG ZUR BEHANDLUNG VON MILCH, INSBESONDERE VON MUTTERMILCH 有权方法和一种用于治疗牛奶，尤其是母乳
公开(公告)号：EP1182934A2
公开(公告)日：2002-03-06
申请号：EP00935139.6
申请日：2000-05-29
IPC分类号： A23C1/00
摘要： According to the inventive method for treating milk, especially breast milk, the milk is momentarily heated in a container (24). The container (24) is set in motion, at least while the milk is being heated, in such a way that a milk film (32) forms on the inner wall (29). The invention also relates to a device (10) for carrying out the method.
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66.发明公开
公开(公告)号：EP1173595A1
公开(公告)日：2002-01-23
申请号：EP00922656.4
申请日：2000-04-20
CPC分类号： C07K14/005 , C12N15/86 , C12N15/87 , C12N15/88 , C12N2770/32322 , C12N2770/32343 , C12N2840/203
摘要： The invention relates to non-infectious particles or peptides derived from the Coxsackie virus which are suited to endosomolytic action and/or endocytose reinforcement in a cell transfection.
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67.发明公开PEPTID AUS ANTIGEN MUC-1 ZUR AUSLÖSUNG EINER IMMINREAKTION GEGEN TUMORZELLEN 有权肽与抗原MUC-1，以诱导免疫应答针对肿瘤细胞的
公开(公告)号：EP1171587A1
公开(公告)日：2002-01-16
申请号：EP00926764.2
申请日：2000-03-28
发明人： KANZ, Lothar , RAMMENSEE, Hans, Georg , BRUGGER, Wolfram , STEVANOVIC, Stefan , BROSSART, Peter
CPC分类号： C07K14/4727 , A61K39/00 , A61K48/00 , A61K2039/53
摘要： The invention relates to a peptide for triggering an immune response to tumor cells. Said peptide has an optionally modified fragment of the protein that is encoded by the gene MUC-1. Said protein triggers an HLA-A2-restricted immune response.
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68.发明公开VERFAHREN ZUR SELEKTION VON PEPTIDEN FÜR ZIELGERICHTETEN PHARMA- UND MARKERTRANSPORT UND PEPTIDE DAMIT ENTDECKT 审中-公开程序于选择肽进行有针对性的药物和分子标记和运输肽DISCOVERED
公开(公告)号：EP1109897A1
公开(公告)日：2001-06-27
申请号：EP99940079.9
申请日：1999-07-30
CPC分类号： C40B40/02 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , C12N15/1037 , G01N33/5088
摘要： The present invention relates to a method for selecting peptides for the targeted transport of drugs and markers. According to this method, a bacteriophage library is applied to an animal and a target structure is prepared outside the animal after incubation. The selected bacteriophages are isolated from the target structure and are applied to another animal after adequate amplification during a new cycle. This invention further relates to peptides selected according to the present method, wherein said peptides penetrate into the intestine mucosa, bind to the endothelial cells of tumors and inflammatory injury and are translocated into the tumor.
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公开(公告)号：EP1073487A1
公开(公告)日：2001-02-07
申请号：EP99915530.2
申请日：1999-02-20
IPC分类号： A61M1/02
CPC分类号： A61M1/0209 , A61M1/0218 , A61M1/029 , A61M2202/0427 , A61M2202/0439 , A61M2205/331 , A61M2202/0042 , A61M2202/0092 , A61M2202/0057
摘要： The invention relates to a method for producing a thrombocyte preparation (27) that is low in leucocytes and erythrocytes from a thrombocyte concentrate (26) containing leucocytes and a residual proportion of erythrocytes. The thrombocyte concentrate (26) is initially centrifuged. The thrombocyte concentrate is subsequently filtered using a leucocyte depletion filter (21), beginning with the centrifugal supernatant. The proportion of erythocytes in the thrombocyte concentrate (26) to be filtered is monitored (16) before passing through to the leucocyte depletion filter (21). The entire filter process is terminated when a specific proportion of erythrocytes is obtained.
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公开(公告)号：EP1014902A1
公开(公告)日：2000-07-05
申请号：EP98950052.5
申请日：1998-09-18
CPC分类号： A61F9/00727 , A61B2017/320044 , A61B2090/062 , A61F9/0017 , A61F9/007 , A61F2250/0067
摘要： The invention relates to a device for accessing the sub-retinal space (36) of an eye (10), comprising an extended flat body consisting of a soft material. Said body can be inserted laterally into the sub-retinal space (36) through an incision (20) in the sclera (12) of the eye (10). The body takes the form of a strip (30), with one surface being configured as a guiding surface for a medical device, for example for implanting a microphotodiode chip (40).
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